Accumulation of visceral fat is positively associated with serum ALT and γ-GTP activities in healthy and preclinical middle-aged Japanese men

Journal of Nutritional Science and Vitaminology

Volumn 57, Issue 1, 2011, Pages 65-73

  Mochizuki, Kazuki ^a   Miyauchi, Rie ^a   Misaki, Yasumi ^a   Shimada, Masaya ^a   Kasezawa, Toshihiko ^b   Tohyama, Kazunari ^b   Goda, Toshinao ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b SHIZUOKA MEDICAL CENTER   (Japan)

Author keywords

GTP; ALT; Healthy and preclinical subjects; Japanese men; Visceral fat

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CIGARETTE SMOKING; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INTRAABDOMINAL FAT; JAPAN; JAPANESE; LIPID STORAGE; MALE; MEDICAL EXAMINATION; MIDDLE AGED; NORMAL HUMAN; PHYSICAL ACTIVITY; SUBCUTANEOUS FAT; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; ALANINE TRANSAMINASE; ASIAN CONTINENTAL ANCESTRY GROUP; ASPARTATE AMINOTRANSFERASES; BODY COMPOSITION; BODY MASS INDEX; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; JAPAN; LINEAR MODELS; LIVER; MALE; MIDDLE AGED; SUBCUTANEOUS FAT;

EID: 79955556547     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.57.65     Document Type: Article

References (27)

1. Vettor R, Milan G, Rossato M, Federspil G. 2005. Review article: Adipocytokines and insulin resistance. Aliment Pharmacol Ther 22 (Suppl 2): 3-10.
2. Brownlee M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820.
3. Ceriello A, Motz E. 2004. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 24: 816-823.
4. Yamada J, Tomiyama H, Yambe M, Koji Y, Motobe K, Shiina K, Yamamoto Y, Yamashina A. 2006. Elevated serum levels of alanine aminotransferase and γ glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome. Atherosclerosis 189: 198-205.
5. Bo S, Gambino R, Durazzo M, Guidi S, Tiozzo E, Ghione F, Gentile L, Cassader M, Pagano GF. 2005. Associations between γ-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: A possible implication for oxidative stress. World J Gastroenterol 11: 7109-7117.
6. Lee DH, Steffen LM, Jacobs DR Jr. 2004. Association between serum γ-glutamyltransferase and dietary factors: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr 79: 600-605.
7. Lieberman MW, Barrios R, Carter BZ, Habib GM, Lebovitz RM, Rajagopalan S, Sepulveda AR, Shi ZZ, Wan DF. 1995. γ-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions? Am J Pathol 147: 1175-1185.
8. Pompella A, Corti A, Paolicchi A, Giommarelli C and Zunino F. 2007. γ-Glutamyltransferase, redox regulation and cancer drug resistance. Curr Opin Pharmacol 7: 360-366.
9. Vozarova B, Stefan N, Lindsay RS, Saremi A, Pratley RE, Bogardus C, Tataranni PA. 2002. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51: 1889-1895.
10. Hanley AJ, Williams K, Festa A, Wagenknecht LE, D'Agostino RB Jr, Haffner SM. 2005. Liver markers and development of the metabolic syndrome: The insulin resistance atherosclerosis study. Diabetes 54: 3140-3147.
11. Miyake Y, Eguchi H, Shinchi K, Oda T, Sasazuki S, Kono S. 2003. Glucose intolerance and serum aminotransferase activities in Japanese men. J Hepatol 38: 18-23.
12. Kim CH, Park JY, Lee KU, Kim JH, Kim HK. 2009. Association of serum γ-glutamyltransferase and alanine aminotransferase activities with risk of type 2 diabetes mellitus independent of fatty liver. Diabetes Metab Res Rev 25: 64-69.
13. Ford ES, Schulze MB, Bergmann MM, Thamer C, Joost HG, Boeing H. 2008. Liver enzymes and incident diabetes: Findings from the European Prospective Investigation into Cancer and nutrition (EPIC)-POTSDAM study. Diabetes Care 31: 1138-1143.
14. Doi Y, Kubo M, Yonemoto K, Ninomiya T, Iwase M, Tanizaki Y, Shikata K, Iida M, Kiyohara Y. 2007. Liver enzymes as a predictor for incident diabetes in a Japanese population: The Hisayama study. Obesity (Silver Spring) 15: 1841-1850.
15. Wannamethee SG, Shaper AG, Lennon L, Whincup PH. 2005. Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men. Diabetes Care 28: 2913-2918.
16. Wajchenberg BL. 2000. Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome. Endocr Rev 21: 697-738.
17. Perrini S, Leonardini A, Laviola L, Giorgino F. 2008. Biological specificity of visceral adipose tissue and therapeutic intervention. Arch Physiol Biochem 114: 277-286.
18. Murakami K, Mizoue T, Sasaki S, Ohta M, Sato M, Matsushita Y. and Mishima N. 2008. Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition 24: 140-147.
19. Mochizuki K, Misaki Y, Miyauchi R, Takabe S, Shimada M, Miyoshi N, Ichikawa Y, Goda T. 2010. Circulating IL-1β and IL-6 concentrations are closely associated with γ-GTP activity in middle-aged japanese men without obvious cardiovascular diseases. Metabolism 59: 1465-1471.
20. Ginn-Pease ME, Whisler RL. 1998. Redox signals and NF-kappaB activation in T cells. Free Radic Biol Med 25: 346-361.
21. Haddad JJ. 2002. Redox regulation of pro-inflammatory cytokines and IkappaB-α/NF-kappaB nuclear translocation and activation. Biochem Biophys Res Commun 296: 847-856.
22. Zhang J, Johnston G, Stebler B, Keller ET. 2001. Hydrogen peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing kinase. Antioxid Redox Signal 3: 493-504.
23. Liu L, Zhong S, Yang R, Hu H, Yu D, Zhu D, Hua Z, Shuldiner AR, Goldstein R, Reagan WJ, Gong DW. 2008. Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells. Protein Expr Purif 60: 225-231.
24. Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM. 2006. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes 55: 2042-2050.
25. Wu C, Okar DA, Kang J, Lange AJ. 2005. Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes. Curr Drug Targets Immune Endocr Metabol Disord 5: 51-59.
26. Jadhao SB, Yang RZ, Lin Q, Hu H, Anania FA, Shuldiner AR, Gong DW. 2004. Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver. Hepatology 39: 1297-1302.
27. Oka R, Miura K, Sakurai M, Nakamura K, Yagi K, Miyamoto S, Moriuchi T, Mabuchi H, Koizumi J, Nomura H, Takeda Y, Inazu A, Nohara A, Kawashiri MA, Nagasawa S, Kobayashi J, Yamagishi M. 2010. Impacts of visceral adipose tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese. Obesity (Silver Spring) 18: 153-160.