"Recreational" drug abuse associated with failure to mount a proper antibody response after a generalised orthopoxvirus infection

Infection

Volumn 35, Issue 6, 2007, Pages 469-473

  Huemer, H P ^a   Himmelreich, A ^b   Honlinger B ^a   Pavlic, M ^a   Eisendle, K ^a   Hopfl R ^a   Rabl, W ^a   Czerny, C P ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; CANNABINOID; NEUTRALIZING ANTIBODY; RECREATIONAL DRUG; VIRUS ANTIBODY;

ADOLESCENT; ALCOHOL INTOXICATION; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; BLOOD SAMPLING; CANNABIS ADDICTION; CASE REPORT; COWPOX VIRUS; DISEASE SEVERITY; HOSPITALIZATION; HUMAN; IMMUNE DEFICIENCY; IMMUNOFLUORESCENCE TEST; MALE; ORTHOPOXVIRUS; POXVIRUS INFECTION; SURVIVAL; URINE LEVEL; WESTERN BLOTTING;

ADOLESCENT; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY FORMATION; CELL LINE; COWPOX; COWPOX VIRUS; HUMANS; MALE; POLYMERASE CHAIN REACTION; STREET DRUGS; SUBSTANCE-RELATED DISORDERS;

EID: 37349066169     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/s15010-007-6194-9     Document Type: Article

References (22)

1. Baxby D, Bennet M, Getty B: Human cowpox 1969-93: a review based on 54 cases. Br J Dermatol 1994; 131: 598-607.
2. Hönlinger B, Huemer HP, Romani N, Czerny CP, Eisendle K, Höpfl R: Generalized cowpox infection probably transmitted from a rat. Br J Dermatol 2005; 153: 451-453.
3. Sale TA, Melski JW, Stratman EJ: Monkeypox: an epidemiologic and clinical comparison of African and US disease. J Am Acad Dermatol 2006; 55: 478-481.
4. Friedman H, Newton C, Klein TW: Microbial infections, immunomodulation, and drugs of abuse. Clin Microbiol Rev 2003; 16: 209-219.
5. Bricklin AS, Musgnug RH: Norwegian scabies. A new complication of immunosuppressive therapy. Cutis 1978; 22: 81-84.
6. Joklik WK: The purification of four strains of poxvirus. Virology 1962; 18: 9-18.
7. Czerny CP, Mahnel H: Structural and functional analysis of orthopoxvirus epitopes with neutralizing monoclonal antibodies. J Gen Virol 1990; 71: 2341-2352.
8. Czerny CP, Johann S, Hoelzle L, Meyer H: Epitope detection in the envelope of intracellular naked orthopoxviruses and identification of encoding genes. Virology 1994; 200: 764-777.
9. Roth MD, Whittaker K, Salehi K, Tashkin DP, Baldwin GC: Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers. J Neuroimmunol 2004; 147: 82-86.
10. Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R, Feldmann M: The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 2000; 97: 9561-9566.
11. Kaminski NE, Koh WS, Yang KH, Lee M, Kessler FK: Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism. Biochem Pharmacol 1994; 48: 1899-1908.
12. Carayon P, Marchand J, Dussossoy D, et al. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood 1998; 92: 3605-3615.
13. Jan TR, Farraj AK, Harkema JR, Kaminski NE: Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice. Toxicol Appl Pharmacol 2003; 188: 24-35.
14. Walter L, Stella N: Cannabinoids and neuroinflammation. Br J Pharmacol 2004; 141: 775-785.
15. Carrier EJ, Auchampach JA, Hilliard CJ: Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA. 2006; 103: 7895-900.
16. Stanojevic S, Dimitrijevic M, Kovacevic-Jovanovic V, Miletic T, Vujic V, Radulovic J: Stress applied during primary immunization affects the secondary humoral immune response in the rat: involvement of opioid peptides. Stress 2003; 6: 247-258.
17. Moraska A, Campisi J, Nguyen KT, Maier SF, Watkins LR, Fleshner M: Elevated IL-1beta contributes to antibody suppression produced by stress. J Appl Physiol 2002; 93: 207-215.
18. Szabo G: Alcohol's contribution to compromised immunity. Alcohol Health Res World 1997; 21: 30-41.
19. Spies CD, von Dossow V, Eggers et al. Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients. Anesthesiology 2004; 100:1088-1100.
20. Taupin V, Jayais P, Descamps-Latscha B, et al. Benzodiazepine anesthesia in humans modulates the interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 responses of blood monocytes. J Neuroimmunol 1991; 35: 13-19.
21. Bednarski JJ, Lyssiotis CA, Roush R, Boitano AE, Glick GD, Opipari AW Jr: A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signalling and apoptosis. J Biol Chem 2004; 279: 29615-29621.
22. El-Gohary M, Eid MA: Effect of cannabinoid ingestion (in the form of bhang) on the immune system of high school and university students. Hum Exp Toxicol 2004; 23: 149-156.