Large quantities of Aβ peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro

Journal of Biological Chemistry

Volumn 286, Issue 18, 2011, Pages 15989-15997

  Moghekar, Abhay ^a   Rao, Sneha ^a   Li, Ming ^a   Ruben, Dawn ^a   Mammen, Andrew ^a   Tang, Xiaopei ^a   O'Brien, Richard J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CORTICAL NEURONS; CULTURED NEURONS; ECTODOMAIN; EXTRACELLULAR; EXTRACELLULAR MEDIUM; EXTRACELLULAR SPACE; HETEROLOGOUS CELLS; HIGH RATE; IN-VITRO; IN-VIVO; PHYSIOLOGICAL CONDITION; TRANSGENICS;

CELL CULTURE; GLYCOPROTEINS; INDUSTRIAL RESEARCH; LAKES; MAMMALS; PEPTIDES; PHYSIOLOGY; PLANTS (BOTANY);

METABOLISM;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO; EXTRACELLULAR SPACE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; JUVENILE ANIMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; STOICHIOMETRY; SWINE; SYNAPSE; ANIMAL; CELL CULTURE; CYTOLOGY; HUMAN; METABOLISM; NERVE CELL; PROTEIN TERTIARY STRUCTURE;

RATTUS; SUIDAE;

AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELLS, CULTURED; HUMANS; NEURONS; PROTEIN STRUCTURE, TERTIARY; RATS;

EID: 79955529460     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.191262     Document Type: Article

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