Costimulation blockade followed by a 12-week period of cyclosporine A facilitates prolonged drug-free survival of rhesus monkey kidney allografts

Transplantation

Volumn 79, Issue 11, 2005, Pages 1623-1626

  Haanstra, Krista G ^a   Sick, Ella A ^a   Ringers, Jan ^b   Wubben, Jacqueline A M ^a   Kuhn, Eva Maria ^c   Boon, Louis ^d   Jonker, Margreet ^a  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c INTERVET INTERNATIONAL BV   (Netherlands)

^d PanGenetics BV   (Netherlands)

Author keywords

Costimulation blockade; Cyclosporine A; Kidney transplantation; Rhesus monkey

Indexed keywords

ALLOANTIBODY; CYCLOSPORIN A; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD40; MONOCLONAL ANTIBODY CD86; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; FOLLOW UP; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LONG TERM CARE; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, CD86; GRAFT REJECTION; GRAFT SURVIVAL; KIDNEY TRANSPLANTATION; MACACA MULATTA; MEMBRANE GLYCOPROTEINS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 20544436235     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000158426.64631.ED     Document Type: Article

References (14)

1. Haanstra KG, Ringers J, Sick EA, et al. Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates. Transplantation 2003; 75(5): 637.
2. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381(6581): 434.
3. Kirk AD, Burkly LC, Batty DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5(6): 686.
4. Taylor PA, Friedman TM, Korngold R, et al. Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood 2002; 99(12): 4601.
5. Torrealba JR, Katayama M, Fechner JH Jr, et al. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J Immunol 2004; 172(9): 5753.
6. Ossevoort MA, Ringers J, Kuhn EM, et al. Prevention of renal allograft rejection in primates by blocking the B7/CD28 pathway. Transplantation 1999; 68(7): 1010.
7. Neuhaus P, Neuhaus R, Wiersema HD, et al. The technique of kidney transplantation in rhesus monkeys. J Med Primatol 1982; 11(3): 155.
8. Ringers J, Haanstra KG, Kroczek RA, et al. Blockade of CD40-CD154 at the time of donor-specific blood transfusion does not lead to prolonged kidney allograft survival in nonhuman primates. Transplantation 2002; 73(6): 862.
9. Schuurman HJ, Slingerland W, Mennninger K, et al. Pharmacokinetics of cydosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting. Transpl Int 2001; 14(5): 320.
10. Hausen B, Klupp J, Christians U, et al. Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys. Transplantation 2001; 72(6): 1128.
11. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55(2): 713.
12. R-Development-Core-Team. R: A Language and Environment for Statistical Computing. Vienna, 2004.
13. Montgomery SP, Xu H, Tadaki DK, et al. Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. Transplantation 2002; 74(10): 1365.
14. Pearson TC, Trambley J, Odom K, et al. Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation 2002; 74(7): 933.