Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-γ-mediated airway hyperreactivity in a murine model of natural rubber latex allergy

American Journal of Respiratory Cell and Molecular Biology

Volumn 44, Issue 5, 2011, Pages 639-647

  Haapakoski, Rita ^a   Karisola, Piia ^a   Fyhrquist, Nanna ^a   Savinko, Terhi ^a   Wolff, Henrik ^a,d   Turjanmaa, Kristiina ^b   Palosuo, Timo ^c   Reunala, Timo ^b   Lauerma, Antti ^a   Alenius, Harri ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Airway hyperreactivity; Airway inflammation; Asthma; Cytosine phosphate guanosine; Natural rubber latex

Indexed keywords

ALLERGEN; CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; METHACHOLINE; NEUTRALIZING ANTIBODY; STAT4 PROTEIN; STAT6 PROTEIN;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; FEMALE; IMMUNOMODULATION; IMMUNOSTIMULATION; INFLAMMATION; LOEFFLER PNEUMONIA; MOUSE; MUCUS SECRETION; NONHUMAN; SENSITIZATION; TH1 CELL; TH2 CELL;

ADMINISTRATION, CUTANEOUS; ANIMALS; BRONCHIAL HYPERREACTIVITY; CPG ISLANDS; CYTOSINE; FEMALE; GUANOSINE; HYPERSENSITIVITY; IMMUNOGLOBULIN E; INFLAMMATION; INTERFERON-GAMMA; LATEX; LUNG; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; PHOSPHATES; RUBBER; TH1 CELLS; TH2 CELLS;

MURINAE;

EID: 79955494615     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0355OC     Document Type: Article

References (41)

1. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299: 1259-1260. (Pubitemid 19280051)
2. Bloomfield SF, Stanwell-Smith R, Crevel RW, Pickup J. Too clean, or not too clean: the hygiene hypothesis and home hygiene. Clin Exp Allergy 2006;36:402-425.
3. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002;20:709-760. (Pubitemid 34293438)
4. Halpern MD, Kurlander RJ, Pisetsky DS. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin- 12 and tumor necrosis factor-alpha. Cell Immunol 1996;167:72-78. (Pubitemid 26048848)
5. RomanM,Martin-Orozco E, Goodman JS, NguyenMD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 1997;3:849-854. (Pubitemid 27353443)
6. Spergel JM. Atopic march: link to upper airways. Curr Opin Allergy Clin Immunol 2005;5:17-21. (Pubitemid 40175491)
7. Lehto M, Haapakoski R, Wolff H, Majuri ML, Makela MJ, Leino M, Reunala T, Turjanmaa K, Palosuo T, Alenius H. Cutaneous, but not airway, latex exposure induces allergic lung inflammation and airway hyperreactivity in mice. J Invest Dermatol 2005;125:962-968.
8. Ahmed DD, Sobczak SC, Yunginger JW. Occupational allergies caused by latex. Immunol Allergy Clin North Am 2003;23:205-219. (Pubitemid 36617730)
9. Reunala T, Alenius H, Turjanmaa K, Palosuo T. Latex allergy and skin. Curr Opin Allergy Clin Immunol 2004;4:397-401. (Pubitemid 39274081)
10. Gauvreau GM, Hessel EM, Boulet LP, Coffman RL, O'Byrne PM. Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses. Am J Respir Crit CareMed 2006;174:15-20. (Pubitemid 43955239)
11. Bernstein D, Segall N, Nayak A, Casale T, Korenblatt P, Martins E. Safety and efficacy of the novel vaccine tolamba in ragweed allergic adults, a dose finding study. J Allergy Clin Immunol 2007;119:S78.
12. Lehto M, KoivuluhtaM,Wang G, Amghaiab I,Majuri ML, Savolainen K, Turjanmaa K, Wolff H, Reunala T, Lauerma A, et al. Epicutaneous natural rubber latex sensitization induces T helper 2-type dermatitis and strong prohevein-specific IgE response. J InvestDermatol 2003;120: 633-640. (Pubitemid 36344007)
13. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997;156:766-775. (Pubitemid 27396413)
14. Davila E, Velez MG, Heppelmann CJ, Celis E. Creating space: an antigen-independent, CpG-induced peripheral expansion of naive and memory T lymphocytes in a full T-cell compartment. Blood 2002;100: 2537-2545.
15. Akimoto T, Numata F, Tamura M, Takata Y, Higashida N, Takashi T, Takeda K, Akira S. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT) 6-deficient mice. J ExpMed 1998;187:1537-1542. (Pubitemid 28215412)
16. Kuperman D, Schofield B, Wills-Karp M, Grusby MJ. Signal transducer and activator of transcription factor 6 (STAT6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 1998;187:939-948. (Pubitemid 28141667)
17. McCusker CT, Wang Y, Shan J, Kinyanjui MW, Villeneuve A, Michael H, Fixman ED. Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide. J Immunol 2007;179:2556-2564.
18. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261. (Pubitemid 29004074)
19. Walter DM, McIntire JJ, Berry G, McKenzie AN, Donaldson DD, DeKruyff RH, Umetsu DT. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 2001; 167:4668-4675. (Pubitemid 32954348)
20. Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008;372: 1107-1119.
21. Klinman DM. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 2004;4:249-258. (Pubitemid 38478660)
22. Goldstein RA, Paul WE, Metcalfe DD, Busse WW, Reece ER. Nih conference: asthma. Ann Intern Med 1994;121:698-708.
23. Broide D, Schwarze J, Tighe H, Gifford T, Nguyen MD, Malek S, Van Uden J, Martin-Orozco E, Gelfand EW, Raz E. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol 1998;161:7054-7062. (Pubitemid 28562256)
24. Santeliz JV, Van Nest G, Traquina P, Larsen E, Wills-Karp M. Amb A 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 2002;109:455-462. (Pubitemid 34234196)
25. Kim YS, Kwon KS, Kim DK, Choi IW, Lee HK. Inhibition of murine allergic airway disease by bordetella pertussis. Immunology 2004;112: 624-630.
26. Shirota H, Sano K, Kikuchi T, Tamura G, Shirato K. Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs. Am J Respir Cell Mol Biol 2000;22:176-182. (Pubitemid 30351480)
27. Serebrisky D, Teper AA, Huang CK, Lee SY, Zhang TF, Schofield BH, Kattan M, Sampson HA, Li XM. CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the b7.1/ b7.2 expression in a murine model of asthma. J Immunol 2000;165: 5906-5912.
28. Agrawal DK, Edwan J, Kandimalla ER, Yu D, Bhagat L, Wang D, Agrawal S. Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma. Int Immunopharmacol 2004;4:127-138. (Pubitemid 38223822)
29. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003;9:582-588. (Pubitemid 36597105)
30. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999; 103:175-183. (Pubitemid 29053135)
31. Takaoka A, Tanaka Y, Tsuji T, Jinushi T, Hoshino A, Asakura Y, Mita Y, Watanabe K, Nakaike S, Togashi Y, et al. A critical role for mouse CXC chemokine(s) in pulmonary neutrophilia during Th type 1-dependent airway inflammation. J Immunol 2001;167:2349-2353. (Pubitemid 32747549)
32. Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T, Matsubara S, Dakhama A, Tager AM, Luster AD, et al. Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD81 T cells and airway hyperresponsiveness. J Immunol 2005; 174:4979-4984.
33. Miyahara N, Swanson BJ, Takeda K, Taube C, Miyahara S, Kodama T, Dakhama A, Ott VL, Gelfand EW. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nat Med 2004;10: 865-869. (Pubitemid 39070861)
34. Corry DB. Emerging immune targets for the therapy of allergic asthma. Natl Rev 2002;1:55-64. (Pubitemid 37361404)
35. Kumar RK, Herbert C, Webb DC, Li L, Foster PS. Effects of anticytokine therapy in a mouse model of chronic asthma. Am J Respir Crit Care Med 2004;170:1043-1048. (Pubitemid 39488615)
36. Kumar RK, Webb DC, Herbert C, Foster PS. Interferon-gamma as a possible target in chronic asthma. Inflamm Allergy Drug Targets 2006;5:253-256. (Pubitemid 44941936)
37. Lewis DB. Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? Curr Opin Immunol 2002;14:644-651.
38. + T cells. Clin Exp Immunol 2005;140:220-229.
39. TakakuraM, Takeshita F, Aihara M, Xin KQ, Ichino M, Okuda K, Ikezawa Z. Hyperproduction of IFN-gamma by CpG oligodeoxynucleotide- induced exacerbation of atopic dermatitis-like skin lesion in some NC/ NGA mice. J Invest Dermatol 2005;125:1156-1162.
40. Wang G, Fyhrquist-Vanni N, Wolff H, Dieu-Nosjean MC, Kemeny L, Homey B, Lauerma AI, Alenius H. Immunostimulatory sequence CpG elicits Th1-type immune responses in inflammatory skin lesions in an atopic dermatitis murinemodel. Int Arch Allergy Immunol 2008;147:41-51.
41. + T cells, a mixed Th1/Th2-type dermatitis and vigorous production of IgE antibodies in the murine model of atopic dermatitis. J Immunol 2005;175:8320-8326.