Testosterone, obesity and insulin resistance in young males: Evidence for an association between gonadal dysfunction and insulin resistance during puberty

Journal of Pediatric Endocrinology and Metabolism

Volumn 23, Issue 12, 2010, Pages 1281-1287

  Moriarty Kelsey, Megan ^a   Harwood, Jeri E F ^a   Travers, Sharon H ^a   Zeitler, Philip S ^a   Nadeau, Kristen J ^a  

^a Children's Hospital Colorado   (United States)

Author keywords

Hypogonadism; Insulin resistance; Insulin sensitivity; Obesity; Puberty; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; INSULIN; TESTOSTERONE;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOCRINE PANCREAS FUNCTION TEST; GONAD DYSFUNCTION; GONAD FUNCTION; HUMAN; HYPERINSULINEMIC EUGLYCEMIC CLAMP; HYPOGONADISM; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PUBERTY; SCHOOL CHILD; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; BODY MASS INDEX; CHILD; HUMANS; HYPOGONADISM; INSULIN RESISTANCE; MALE; OBESITY; PUBERTY; TESTOSTERONE;

EID: 79955486308     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/jpem.2010.202     Document Type: Article

References (23)

1. Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, et al. Secondary sexual characteristics and menses in young girls seen in office practice: A study from the Pediatric Research in Office Settings Network. Pediatrics 1997; 99:505-12.
2. Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sorensen TIA, et al. Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 2008;121(suppl 3):S172-S191.
3. Kaplowitz PB. Link between body fat and the timing of puberty. Pediatrics 2008;121(suppl 3):S208-S217.
4. Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics 2002;110: 903-10. (Pubitemid 35266148)
5. Vignolo M, Naselli A, Di BE, Mostert M, Aicardi G. Growth and development in simple obesity. Eur J Pediatr 1988;147:242-4.
6. Denzer C, Weibel A, Muche R, Karges B, Sorgo W, Wabitsch M. Pubertal development in obese children and adolescents. Int J Obes (Lond) 2007;31:1509-19. (Pubitemid 47482668)
7. Lee JM, Kaciroti N, Appugliese D, Corwyn RF, Bradley RH, Lumeng JC. Body Mass Index and Timing of Pubertal Initiation in Boys. Arch Pediatr Adolesc Med 2010 February 1;164(2):139-44.
8. Sorensen K, Aksglaede L, Petersen JH, Juul A. Recent Changes in Pubertal Timing in Healthy Danish Boys: Associations with Body Mass Index. J Clin Endocrinol Metab 2009 November 19;jc.
9. Allan CA, Strauss BJ, McLachlan RI. Body composition, metabolic syndrome and testosterone in ageing men. Int J Impot Res 2007;19:448-57. (Pubitemid 47367519)
10. Az-Arjonilla M, Schwarcz M, Swerdloff RS, Wang C. Obesity, low testosterone levels and erectile dysfunction. Int J Impot Res 2008;21:89-98.
11. Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab 2004;89:5462-8. (Pubitemid 39518427)
12. Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Valkonen VP, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004;27:1036-41. (Pubitemid 38579762)
13. Kaplan SA, Meehan AG, Shah A. The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively High Incidence of erectile dysfunction observed in these men? Journal Urol 2006;176:1524-8. (Pubitemid 44307192)
14. Adair LS, Gordon-Larsen P. Maturational timing and overweight prevalence in US adolescent girls. Am J Public Health 2001;91:642-4. (Pubitemid 32248706)
15. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. Relation of age at menarche to race, time period, and anthropometric dimensions: the Bogalusa Heart Study. Pediatrics 2002;110:e43.
16. Himes JH, Obarzanek E, Baranowski T, Wilson DM, Rochon J, McClanahan BS. Early sexual maturation, body composition, and obesity in African-American girls. Obes Res 2004; Suppl:64S-72S.
17. Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME. Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics 2001;108:347-53.
18. Nadeau KJ, Zeitler PS, Bauer TA, Brown MS, Dorosz JL, Draznin B, et al. Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab 2009;94: 3687-95.
19. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223. (Pubitemid 9249478)
20. Ahmed ML, Ong KKL, Morrell DJ, Cox L, Drayer N, Perry L, et al. Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab 1999;84:899-905. (Pubitemid 29138215)
21. Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 1997;82:2849-55. (Pubitemid 27385638)
22. Kaplowitz P. Delayed puberty in obese boys: comparison with constitutional delayed puberty and response to testosterone therapy. J Pediatr 1998;133:745-9. (Pubitemid 28563942)
23. Ding EL, Song Y, Manson JE, Hunter DJ Lee CC, Rifai N, Buring JE, Gaziano JM, Liu S. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009 September 17;361(12):1152-63.