The Age Related Decrease in Testosterone is Significantly Exacerbated in Obese Men With the Metabolic Syndrome. What are the Implications for the Relatively High Incidence of Erectile Dysfunction Observed in These Men?

Journal of Urology

Volumn 176, Issue 4, 2006, Pages 1524-1528

  Kaplan, Steven A ^a   Meehan, Alan G ^b   Shah, Arvind ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

age factors; hypogonadism; metabolic syndrome x; obesity

Indexed keywords

LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGING; ANTHROPOMETRY; ARTICLE; BODY MASS; CLINICAL ASSESSMENT; CLINICAL OBSERVATION; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION COEFFICIENT; DATA ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; ENDOCRINE DISEASE; ERECTILE DYSFUNCTION; GLUCOSE BLOOD LEVEL; HEALTH; HUMAN; HYPERGLYCEMIA; INCIDENCE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MULTIPLE LINEAR REGRESSION ANALYSIS; OBESITY; PRIORITY JOURNAL; STATISTICAL MODEL; TESTOSTERONE BLOOD LEVEL;

AGE FACTORS; BODY MASS INDEX; COHORT STUDIES; HUMANS; IMPOTENCE; INCIDENCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; TESTOSTERONE;

EID: 33748120349     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2006.06.003     Document Type: Article

References (14)

1. Aversa A., Isidori A.M., De Martino M.U., Caprio M., Fabbrini E., Rocchietti-March M., et al. Androgens and penile erection. evidence for a driect relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction. Clin Endocrinol (Oxf) 53 (2000) 517
2. Foresta C., Caretta N., Rossato M., Garolla A., and Ferlin A. Role of androgens in erectile function. J Urol 171 (2004) 2358
3. Harman S.M., Metter E.J., Tobin J.D., Pearson J., Blackman M.R., and Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86 (2001) 724
4. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., et al. Age trends in the level of serum testosterone and other hormones in middle-aged men. longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87 (2002) 589
5. Matsumoto A.M. Andropause. clinical implications of the decline in serum testosterone levels with aging in men. J Gerontol A Biol Sci Med Sci 57 (2002) M76
6. Ford E.S., Giles W.H., and Dietz W.H. Prevalence of the metabolic syndrome among US adults. JAMA 287 (2002) 356
7. Laaksonen D.E., Niskanen L., Punnonen K., Nyyssönen K., Tuomainen T.-P., Valkonen V.-P., et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 27 (2004) 1036
8. Laaksonen D.E., Niskanen L., Punnonen K., Nyyssönen K., Tuomainen T.-P., Valkonen V.-P., et al. The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men. a prospective cohort study. J Clin Endocrinol Metab 90 (2005) 712
9. Pitteloud N., Mootha V.K., Dwyer A.A., Hardin M., Lee H., Eriksson K.-F., et al. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care 28 (2005) 1636
10. Dhindsa S., Prabhakar S., Sethi M., Bandyopadhyay A., Chaudhuri A., and Dandona P. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetics. J Clin Endocrinol Metab 89: (2004) 5462
11. Executive Summary of The Third Report of The National Cholesterol Eduction Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285 (2001) 2486
12. Summary from the Second Annual Andropause 2001 Consensus Meeting of the Endocrine Society. Available at www.endo-society.org/publicpolicy/legislative/upload/andro_cc_summary.pdf. Accessed October 11, 2005
13. Esposito K., Giugliano F., Martedi E., Feola G., Marfella R., D'Armiento M., et al. High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 28 (2005) 1201
14. Shabsigh R., Kaufman J.M., Steidle C., and Padma-Nathan H. Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. J Urol 172 (2004) 658