Effect of clarithromycin and azithromycin on production of cytokines by human monocytes

International Journal of Antimicrobial Agents

Volumn 11, Issue 2, 1999, Pages 121-132

  Khan, Anis A ^a,b   Slifer, Teri R ^a   Araujo, Fausto G ^a   Remington, Jack S ^a,b  

^a PALO ALTO MEDICAL FOUNDATION   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Azithromycin; Clarithromycin; Cytokine; Immunomodulation; Macrolide; Monocyte

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PANSORBIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL CULTURE; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CLARITHROMYCIN; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; MONOCYTES;

EID: 0032965556     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(98)00091-0     Document Type: Article

References (41)

1. Iino Y, Toriyama M, Kudo K, Natori Y, Yuo A. Erythromycin inhibition of lipopolysaccharide-stimulated tumor necrosis factor alpha production by human monocytes in vitro. Ann Otol Rhinol Laryngol 1992;101:16-20.
2. Korzeniowski OM. Effects of antibiotics on the mammalian immune system. Infect Dis Clin North Am 1989;3:469-78.
3. Morikawa K, Oseko F, Morikawa S, Iwamoto K. Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin and clarithromycin, on human T-lymphocytes function in vitro. Antimicrob Agents Chemother 1994;38:2643-7.
4. Morikawa K, Watabe H, Araake M, Morikawa S. Modulatory effect of antibiotics on cytokine production by human monocytes in vitro. Antimicrob Agents Chemother 1996;40:1366-70.
5. Stevens DL. Immune modulatory effects of antibiotics. Curr Opin Infect Dis 1996;9:165-9.
6. Takeshita K, Yamagishi I, Harada M, Otomo S, Nakagawa T, Mizushima Y. Immunological and anti-inflammatory effects of clarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages. Drugs Exp Clin Res 1989;15:527-33.
7. Van Vlem B, Vanholder R, De Paepe P, Vogelaers D, Ringoir S. Immunomodulating effects of antibiotics: literature review. Infection 1996;24:275-91.
8. Lührman A, Thölke J, Behn I, Schumann J, Tiegs G, Hauschildt S. Immunomodulating properties of the antibiotic novobiocin in human monocytes. Antimicrob Agents Chemother 1998;42:1911-6.
9. Bryskier AJ, Butzler J-P, Neu HC, Tulkens PM, editors. Macrolides: chemistry, pharmacology and clinical use. Paris: Blackwell, 1993.
10. Araujo FG, Guptill DR, Remington JS. Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii. Antimicrob Agents Chemother 1988;32:755-7.
11. Araujo FG, Prokocimer P, Lin T, Remington JS. Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis. Antimicrob Agents Chemother 1992;36:2454-7.
12. Araujo FG, Lin T, Remington JS. Synergistic combination of azithromycin and sulfadiazine for treatment of toxoplasmosis in mice. Eur J Clin Microbiol Infect Dis 1992;11:71-3.
13. Stevens DL, Hackett S, Bryant AE. Suppression of mononuclear cell synthesis of tumor necrosis factor by azithromycin. In: 35th Annul Meeting, of the Infectious Diseases Society of America. Alexandria, VA, 1997.
14. Parjis LV, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 1998;280:243-8.
15. Gazzinelli RT, Wysocka M, Hieny S, et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4 + T-cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J Immunol 1996;157:798-805.
16. Ellis Neyer L, Grunig G, Fort M, Remington JS, Rennick D, Hunyer CA. Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii. Infect Immunol 1997;65:1675-82.
17. Khan AA, Slifer TR, Remington JS. Effect of trovafloxacin on production of cytokines by human monocytes. Antimicrob Agents Chemother 1998;42:1713-7.
18. Braumann H, Gauldie J. The acute phase response. Immunol Today 1994;15:74-89.
19. Chin J, Kostura MJ. Dissociation of IL-1β synthesis and secretion in human blood monocytes stimulated with bacterial cell wall products. J Immunol 1993;151:5574-81.
20. Tocchi MJ, Hutchinson NI, Cameron PM, et al. Expression in Escherichia coli and characterization of recombinant human interleukin-1β: comparison with native IL-1β. J Immunol 1987;138:1109-14.
21. Lonnemann G, Endres S, Van Der Meer JW, Cannon JG, Koch KM, Dinarello CA. Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells. Eur J Immunol 1989;19:1531-6.
22. Tracey KJ. Tumor necrosis factor. In: Remick DG, Friedland JS, editors. Cytokines in health and disease. New York: Marcel Dekker, 1997.
23. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-20.
24. Moore GW, O'Garra A, de Waal-Malefyt R, Vieria P, Mosman T. Interleukin-10. Ann Rev Immunol 1993;11:167-90.
25. Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 1994;83:113-8.
26. Grabstein KH, Urdal DL, Tushinski RJ, et al. Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science 1986;232:232-506.
27. Handman E, Burgess AW. Stimulation by granulocyte-macrophage colony stimulating factor of Leishmania tropica killing by macrophages. J Immunol 1979;122:1134.
28. Mayer P, Lam C, Obenaus H, Liehl E, Besemer J. Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polymorphonuclear neutrophils in non-human primates. Blood 1987;70:206-13.
29. Metcalf D. Hemapoietic colonies. In vitro cloning of normal and leukemic cells. Berlin: Springer, 1977.
30. McDonald PJ, Pruul H. Macrolides and the immune system. Scand J Infect Dis 1992;83:34-40.
31. Gladue RP, Snider ME. Intracellular accumulation of azithromycin by cultured human fibroblasts. Antimicrob Agents Chemother 1990;34:1056-60.
32. Cheng KL, Nafziger AN, Peloquin CA, Amsden GW. Effect of grapefruit juice on clarithromycin pharmacokinetics. Antimicrob Agents Chemother 1998;42:927-9.
33. Patel KB, Xuan D, Tessier PR, Russomanno JH, Quintiliani R, Nightingale CH. Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. Antimicrob Agents Chemother 1996;40:2375-9.
34. Hafner R, Bethel J, Power M, et al. Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers. Antimicrob Agents Chemother 1998;42:631-9.
35. Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990;25:73-82.
36. Morris DL, De Souza A, Jones JA, Morgan WE. High and prolonged pulmonary tissue concentrations of azithromycin following a single oral dose. Eur J Clin Microbiol Infect Dis 1991;10:859-61.
37. Stray-Pedersen B, The European Research Network on Congenital Toxoplasmosis Treatment Group. Azithromycin levels in placental tissue, amniotic fluid and blood. In: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, DC, 1996.
38. Jaruratanasirikul S, Hortiwakul R, Tantisarasart T, Phuenpathom N, Tussanasunthornwong S. Distribution of azithromycin into brain tissue, cerebrospinal fluid and aqueous humor of the eye. Antimicrob Agents Chemother 1996;40:825-6.
39. Luke DR, Foulds G, Cohen SF, Levy B. Safety, toleration and pharmacokinetics of intravenous azithromycin. Antimicrob Agents Chemother 1996;40:2577-81.
40. Cooper MA, Nye K, Andrews JM, Wise R. The pharmacokinetics of inflammatory fluid penetration of orally administered azithromycin. J Antimicrob Chemother 1990;26:533-8.
41. Williams MA, White SA, Miller JJ, et al. Granulocyte-macrophage colony-stimulating factor induces activation and restores respiratory burst activity in monocytes from septic patients. J Infect Dis 1998;177:107-15.