Development of new indole-derived neuroprotective agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 9, 2011, Pages 2966-2974

  Mohareb, Rafat M ^a,b   Ahmed, Hanaa H ^c   Elmegeed, Gamal A ^c   Abd Elhalim, Mervat M ^c   Shafic, Reham W ^c  

^a OCTOBER UNIVERSITY FOR MODERN SCIENCES AND ARTS MSA   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Indole; Neuroprotective; Pyrazole; Pyridine; Pyrimidine; Tetrazole; Tryptophan

Indexed keywords

1 (3,5 DIAMINO 4,5 DIHYDRO 1 PHENYLPYRAZOL 4 YL) 3 (1H INDOL 3 YL) 2 (METHYLENAMINO)PROPAN 1 ONE; 1 (3,5 DIAMINO 4,5 DIHYDRO 1H PYRAZOL 4 YL) 3 (1H INDOL 3 YL) 2 (METHYLENAMINO)PROPAN 1 ONE; 1 (4,6 DIAMINO 2 IMINO 5H PYRIMIDIN 5 YL) 3 (1H INDOL 3 YL) 2 (METHYLENAMINO)PROPAN 1 ONE; 1 (4,6 DIAMINO 2 OXO 5H PYRIMIDIN 5 YL) 3 (1H INDOL 3 YL) 2 (METHYLENAMINO)PROPAN 1 ONE; 1 (4,6 DIAMINO 2 THIOXO 5H PYRIMIDIN 5 YL) 3 (1H INDOL 3 YL) 2 (METHYLENAMINO)PROPAN 1 ONE; 2 (1H TETRAZOLE 5 METHYLENCARBOXAMIDO) 3 (1H INDOL 3 YL)PROPANOIC ACID; 2 [(1H INDOL 3 YL)METHYL] 5 AMINO 3 (PHENYLAMINO)PYRIDINE 4 CARBONITRILE; 2 CYANO 5 (1H INDOL 3 YL) 4 (METHYLENAMINO) 3 OXOPENTANONITRILE; 3 (1H INDOL 3 YL) 2 (METHYLENAMINO) N PHENYLPROPANAMIDE; 3 (1H INDOL 3 YL) 2 (METHYLENAMINO)PROPANOIC ACID; 3 (1H INDOL 3 YL) 2 (METHYLENAMINO)PROPANOYL CHLORIDE; ACRYLAMIDE; ETHYL 2 [(1H INDOL 3 YL)METHYL] 5 AMINO 3 (PHENYLAMINO)PYRIDINE 4 CARBOXYLATE; INDOLE DERIVATIVE; INDOLYLMETHYLPYRIDINE DERIVATIVE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PYRAZOLYLINDOYLMETHYLENAMINOPROPAN 1 ONE DERIVATIVE; PYRIMIDINYLINDOLYLMETHYLENAMINO PROPAN 1 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; GLUTATHIONE METABOLISM; LIPID PEROXIDATION; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ROOM TEMPERATURE;

ANIMALS; BRAIN; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INDOLES; LACTATE DEHYDROGENASES; MALONDIALDEHYDE; NEUROPROTECTIVE AGENTS; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

RATTUS;

EID: 79955479319     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.031     Document Type: Article

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