Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 3898-3909

  Koufaki, Maria ^a   Theodorou, Elissavet ^a   Alexi, Xanthippi ^a   Alexis, Michael N ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

Bioisosterism; Catechol; Chroman; Neuronal damage; Oxidative stress

Indexed keywords

1 (3,4 DIHYDROXYBENZYL) 4 (3,4 DIHYDRO 6 HYDROXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL) 1,2,3 TRIAZOLE; 1 (3,4 DIMETHOXYBENZYL) 4 (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL) 1,2,3 TRIAZOLE; 2 (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN) 5 (3,4 DIMETHOXYBENZYL) 1,3,4 OXADIAZOLE; 2 (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN) 5 (3,4 DIMETHOXYPHENYL) 1,3,4 OXADIAZOLE; 3 (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 2 YL) 5 (3,4 DIMETHOXYPHENYL) 1,2,4 OXADIAZOLE; 3 (3,4 DIHYDROXYPHENYL) 5 (3,4 DIHYDRO 6 HYDROXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL)ISOXAZOLE; 3 (3,4 DIMETHOXYPHENYL) 5 (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL)ISOXAZOLE; 4 (3,4 DIHYDROXYPHENYL) 1 [(3,4 DIHYDRO 6 HYDROXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL)METHYL] 1,2,3 TRIAZOLE; 4 (3,4 DIMETHOXYPHENYL) 1 [(3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL) METHYL] 1,2,3 TRIAZOLE; 5 (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN) 3 (3,4 DIMETHOXYBENZYL) 1,2,4 OXADIAZOLE; 5 (3,4 DIHYDROXYPHENYL) 3 (3,4 DIHYDRO 6 HYDROXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL)ISOXAZOLE; 5 (3,4 DIMETHOXYPHENYL) 3 (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL)ISOXAZOLE; 5 (3,4 DIMETHOXYPHENYL) 3 [(3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL)METHYL] 1,2,4 OXADIAZOLE; 5 [(3,4 DIHYDROXYPHENYL)] 3 [(3,4 DIHYDRO 6 HYDROXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL) METHYL] 1,2,4 OXADIAZOLE; 5 [1 (3,4 DIHYDROXYPHENYL)METHYL] 3 [(3,4 DIHYDRO 6 HYDROXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL) METHYL] 1,2,4 OXADIAZOLE; 5 [2 (3,4 DIHYDROXYPHENYL)ETHYL] 3 [(3,4 DIHYDRO 6 HYDROXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL) METHYL] 1,2,4 OXADIAZOLE; 5 [2 (3,4 DIHYDROXYPHENYL)VINYL] 3 [(3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL) METHYL] 1,2,4 OXADIAZOLE; 5 [2 (3,4 DIMETHOXYPHENETHYL)] 3 [(3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 YL)METHYL] 1,2,4 OXADIAZOLE; 5 [2 (3,4 DIMETHOXYPHENYL)VINYL] 3 [(3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 5 YL)METHYL] 1,2,4 OXADIAZOLE; GLUTAMIC ACID; N (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 2 CARBONYL) N' (3,4 DIMETHOXYPHENYL CARBONYL)HYDRAZINE; N (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 2 CARBONYLOXY) N' (3,4 DIMETHOXY)BENZIMIDAMIDE; N (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 2 CARBONYLOXY) N' (3,4 DIMETHOXYPHENYL)ACETIMIDAMIDE; N (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 ETHYL) 3 (3,4 DIMETHOXY PHENYLPROPANETHIOAMIDE); N (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 METHYL) 3 (3,4 DIMETHOXYPHENYL PROPANE THIOAMIDE); NEUROPROTECTIVE AGENT; O (3,4 DIMETHOXYBENZOYL) (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 ACETAMIDOXIME); O (3,4 DIMETHOXYPHENYLACETYL) (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 ACETAMIDOXIME); O (3,4 DIMETHOXYPHENYLPROPENOYL) (3,4 DIHYDRO 6 METHOXY 2,2,7,8 TETRAMETHYL 2Y 1 BENZOPYRAN 5 ACETAMIDOXIME; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; HYBRID; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROVOCATION TEST; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZOLES; CATECHOLS; CELL DEATH; CELL LINE; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; MICE; NEURONS; OXIDATIVE STRESS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953131180     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.042     Document Type: Article

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