Palatal mucosa as a route for systemic drug delivery: A review

Journal of Controlled Release

Volumn 151, Issue 1, 2011, Pages 2-9

  Shakya, Pragati ^c   Madhav, N V Satheesh ^a   Shakya, Ashok K ^b   Singh, Kuldeep ^c  

^a Dehradoon Institute of Technology   (India)

^b AL AHLIYYA AMMAN UNIVERSITY   (Jordan)

^c INTEGRAL UNIVERSITY   (India)

Author keywords

Mucoadhesive; Non invasive route; Orotransmucosal

Indexed keywords

ACIDIC ENVIRONMENT; DELIVERY SYSTEMS; DOSAGE FORMS; DRUG DELIVERY SYSTEM; GENE TECHNOLOGY; HAZARDOUS EFFECTS; MACROMOLECULAR DRUGS; MUCOADHESIVE; NON-INVASIVE; ORAL ABSORPTION; ORAL DELIVERY; OROTRANSMUCOSAL; PATIENT COMPLIANCE; RAPID DEVELOPMENT; RECOVERY TIME; SITE-SPECIFICITY; SMOOTH SURFACE; SOFT PALATES; THERAPEUTIC AGENTS; TOXIC EFFECT; TRANSDERMAL; VASCULARIZATION;

BIOCHEMISTRY; DRUG PRODUCTS; GENES; MOLECULAR BIOLOGY; NUCLEIC ACIDS; PROTEINS;

DRUG DELIVERY;

ALCOHOL; BILE SALT; DENDRIMER; ESTER; FATTY ACID; ISCOM; LIPOSOME; MICROSPHERE; NANOCAPSULE; NANOCARRIER; NANOPARTICLE; PENETRATION ENHANCING AGENT; POLYMER; SURFACTANT;

CHEEK MUCOSA; CHEWING GUM; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; EMULSION; ENVIRONMENTAL FACTOR; FILM; HOLLOW FIBER; HYDROGEL; MEMBRANE PERMEABILITY; MORPHOLOGY; MUCOADHESION; MUCUS SECRETION; NONHUMAN; POWDER; PRIORITY JOURNAL; REVIEW; SALIVATION; SOFT PALATE; TABLET; TABLET FORMULATION;

ADMINISTRATION, MUCOSAL; ADMINISTRATION, ORAL; ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; MOUTH MUCOSA; PALATE; PHARMACEUTICAL PREPARATIONS;

EID: 79955474943     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.11.003     Document Type: Review

References (123)

1. M.J. Rathbone, and J. Hadgraft Absorption of drugs from the human oral cavity Int. J. Pharm. 74 1991 9 24
2. M.E. de Vries, H.E. Bodde, J.C. Verhoef, and H.E. Junginger Developments in buccal drug delivery Crit. Rev. Ther. Drug Carrier Syst. 8 1991 271 303
3. H.E. Bodde, M.E. De Vries, and H.E. Junginger Mucoadhesive polymers for the buccal delivery of peptides, structure-adhesiveness relationships J. Control. Release 13 1990 225 231 (Pubitemid 20313520)
4. G.R. Mettam, and L.B. Adams How to Prepare an Electronic Version of Your Article B.S. Jones, R.Z. Smith, Introduction to the Electronic Age 1999 E-Publishing Inc. New York 281 304
5. R.B. Gandhi, and J.R. Robinson Oral cavity as a site for bioadhesive drug delivery Adv. Drug Deliv. Rev. 13 1994 43 74 (Pubitemid 24032041)
6. C.A. Squier, and P.W. Wertz Structure and Function of the Oral Mucosa and Implications for Drug Delivery Rathbone M.J. Oral Mucosal Drug Delivery 1996 Marcel Dekker 1 25
7. A. Siegel Permeability of the Oral Mucosa J. Meyer, C.A. Squier, S.J. Gerson, The Structure and the Function of Oral Mucosa 1984 Pergamon Press Oxford 95 108
8. C.A. Squier, N.W. Johnson, and R.M. Hopps The Organization of Oral Mucosa Human Oral Mucosa, Development, Structure and Function 1976 Blackwell Scientific Publications Oxford 7 15
9. S.-Y. Chen, and C.A. Squier The Ultrastructure of the Oral Epithelium J. Meyer, C.A. Squier, S.J. Gerson, The Structure and Function of Oral Mucosa 1984 Pergamon Press Oxford 7 30
10. K.W. Gerson, and R.R. Harris The Structure and Function of Oral Mucosa J. Meyer, C.A. Squier, S.J. Gerson, The Structure and Function of Oral Mucosa 1984 Pergamon Press Oxford 31 51 20
11. A. Allen, A. Bell, and S. McQueen Mucus and Mucosal Protection A. Allen, G. Flemstro, A. Garner, W. Silen, L.A. Turnberg, Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract 1984 Raven Press New York 195 202
12. C.-M. Lehr From sticky stuff to sweet receptors-achievements, limits and novel approaches to bioadhesion Eur. J. Drug Metab. Pharmacokinet. 21 1996 139 148 (Pubitemid 26246157)
13. J. Haas, and C.-M. Lehr Developments in the area of bioadhesive drug delivery systems Expert Opin. Biol. Ther. 2 2002 287 298 (Pubitemid 34464810)
14. C.A. Squlcr, and N.V. Johnson Permeability of oral mucosa Br. Mcd. Bull. 31 1975 1969 1975
15. C.A. Squier, R.A. Eady, and R.M. Hopps The permeability of epidermis lacking normal membrane-coating granules: an ultrastructural tracer study of Kyrle-Flegel disease J. Invest. Dermatol. 70 1978 361 364 (Pubitemid 8369152)
16. C.A. Squier, and B.K. Hall The permeability of mammalian nonkeratinized oral epithelia to horseradish peroxidise applied in vivo and in vitro Arch. Oral Biol. 29 1984 45 50
17. I.A. Siegel, S.H. Hall, and R. Stambaugh Permeability of the Oral Mucosa C.A. Squier, J. Meyer, Current Concepts of the Histology of Oral Mucosa 1971 Carles Thomas Springfield, IL 274 286
18. Zhoua X.H., and Li Wan Po A. Peptide and protein drugs: II. Non-parenteral routes of delivery Int. J. Pharm. 75 1991 117 130
19. U. Bertram, and R. Bodmeier In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form Eur. J. Pharm. Sci. 27 2006 62 71 (Pubitemid 41728256)
20. K.E. Thummel, K.L. Kunze, and D.D. Shen Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction Adv. Drug Deliv. Rev. 27 1997 99 127 (Pubitemid 27417869)
21. M.T. De Meo, E.A. Mutlu, A. Keshavarzian, and M.C. Tobin Intestinal permeation and gastrointestinal disease J. Clin. Gastroenterol. 34 2002 385 396
22. J. Varshosaz Insulin delivery systems for controlling diabetes, recent patents on endocrine Metab. Immune Drug Discov. 1 2007 25 40
23. J. Woodley Bioadhesion: new possibilities for drug administration? Clin. Pharmacokinet. 40 2001 77 84 (Pubitemid 32242791)
24. Waugh A., Grant A., Anatomy and physiology in health and illness-the digestive system '10th edition, Churchill Livingstone, 28.
25. N.V. Satheesh and M.S. Uma Shankar, A novel oro-soft palatal platform for transmucosal gentamicin delivery, Proceedings of ICSS held at Jadavpur University on 13th February 2008. 21.
26. N.V. Satheesh and M.S. Uma Shankar, A. Maurya, A Smart Bioplate from Lallimantia royalena Seeds fro Trans-soft Palatal Delivery, Proceedings of International Conference on Innovations in Drug Delivery from Biomaterial to Devices Held at Naples, Italy 30th September-3rd October.
27. A. Ahuja, R.K. Khar, and J. Ali Mucoadhesive drug delivery systems Drug Dev. Ind. Pharm. 19 1993 143 194
28. J. Ali, R.K. Khar, A. Ahuja, and R. Kalra Bucoadhesive erodible disk for treatment of orodental infections: design and characterisation Int. J. Pharm. 238 2002 93 103 (Pubitemid 34457878)
29. Y.W. Chien Novel drug delivery system, mucosal drug delivery: potential routes for noninvasive systemic administration 1992 Marcel Dekker New York 197
30. K.P.R. Chowdary, and L. Srinivas Mucoadhesive drug delivery system: a review of current status Indian Drugs 37 2000 400 406 (Pubitemid 32123747)
31. N.V. Satheesh, and M.S. Uma Shankar A Smart Flexiplate for Oral Transmucosal Soft Palatal Delivery of Amikacin-Proceedings of the International world PSWC 2007 held in April 22-23, 2007 at Amsterdam, Netherland
32. N.V. Satheesh and M.S. Uma Shankar, A Smart Soft Palatal Platform for Oral Transmucosal Delivery by Using Drug-loaded Mangifera indica, Proceedings of bioplate-Indian Pharmaceutical Congress Held at BHU on 23-25 December 2007.
33. D.V. Provenza, and Seibell W. Oral histology: inheritance and development Philadelphia lie and febiger 2nd edition 1986 407
34. F. Paulsen, and A. Thale Epithelial-connective tissue boundary in the oral part of the human soft palate J. Anat. 193 1998 457 467 (Pubitemid 28534902)
35. K. Dhaneshwar, L. Rathi, T. Avinash, and M. Yogesh A review on oral mucosal drug delivery system Int. J. Pharm. Sci. Res. 1 5 2010 50 56
36. T. Disabato-mordarski, and I. Kleinberg Measurement and comparison of the residual saliva on various oral mucosal and dentition surfaces in humans Arch. Oral Biol. 41 1996 655 665 (Pubitemid 27089663)
37. L. Eliasson, D. Birkhed, G. Heyden, and N. Strömberg Studies on human minor salivary gland secretions using the Periotron method Arch. Oral Biol. 41 1996 1179 1182 (Pubitemid 27123133)
38. J. Kocevar-Nared, J. Kristl, and J. Smid-Korbar Comparative rheological investigation of crude gastric mucin and natural gastric mucus Biomaterials 18 1997 677 681 (Pubitemid 27267830)
39. R.D. Specian, and M.R. Neutra Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine J. Cell Biol. 85 1980 626 640 (Pubitemid 10007432)
40. R.A. Cone Barrier properties of mucus Adv. Drug Deliv. Rev. 61 2009 75 85 22
41. K. Khanvilkar, M. Donovan, and D. Flanagan Drug transfer through mucus Adv. Drug Deliv. Rev. 48 2001 173 193 (Pubitemid 32434402)
42. Y. Cu, and W.M. Saltzman Mathematical modeling of molecular diffusion through mucus Adv. Drug Deliv. Rev. 61 2009 101 114
43. A. Allen The Gastrointestinal Physiology. Salivary, Gastric and Hepatobiliary Secretions J.G. Forte, Handbook of Physiology, Vol. III Section 6 1989 American Physiological Society Bethesda, MD 359 382
44. D.A. Norris, N. Puri, and P.J. Sinko The effect of physical barriers and properties on the oral absorption of particulates Adv. Drug Deliv. Rev. 34 2-3 1998 135 154 (Pubitemid 28535109)
45. M.R. Castellanos, H. Zia, and C.T. Rhodes Mucoadhesive drug delivery systems Drug Dev. Ind. Pharm. 19 1 and 2 1993 143 194
46. C. Marriot, and D.R.L. Hughes R. Gurny, H.E. Junginger, Mucus Physiology and Pathology Bioadhesion-Possibilities and Future Trends 1990 WissenschaftlicheVerlagsgesellschaft mbH Stuttgart 29 43
47. E. Puchelle Rheology, biochemistry and functions of mucus Biorheology 24 1987 411 423
48. P. Verdugo Goblet cells secretion and mucogenesis Ann. Rev. Physiol. 52 1990 157 176 (Pubitemid 20103532)
49. A. Allen, D.A. Hutton, J.P. Pearson, and L.A. Sellars Mucus glycoprotein, structure, gel formation and gastrointestinal mucus function, mucus and mucosa Ciba Found. Symp. 109 1984 137 156
50. G.J. Strous, and J. Dekker Mucin-type glycoproteins Crit. Rev. Biochem. Mol. Biol. 27 1992 57 92
51. A. MacAdam The effects of gastro-intestinal mucus on drug adsorptions Adv. Drug Deliv. Rev. 11 1993 201 220 (Pubitemid 23302846)
52. L.S. Watanabe, T. Inokuchi, M. Hamasaki, and E. Yamada Three dimensional organization of the epithelium-connective tissue interface of the tongue and soft palate in the Macaca fuscata: a SEM study Acta Microsc. 4 1 1995 59 73
53. G. Flemström, A. Hä llgren, O. Nylander, L. Engstrand, E. Wilander, and A. Allen The adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo Am. J. Physiol. Gastrointest. Liver Physiol. 277 1999 G375 G382
54. L. Serra, J. Doménech, and N.A. Peppas Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents Eur. J. Pharm. Biopharm. 71 3 2009 519 528 23
55. A. Nagia Science and technology of bioadhesive-based targeted oral delivery systems Pharm. Technol. 32 11 2008 100 121
56. D.E. Chickering, and E. Mathiowitz Definitions, Mechanism, and Theories of Bioadhesion E. Mathiowitz, D.E. Chickering, C.M. Lehr, Bioadhesive Drug Delivery System 1999 Marcel Dekker New York, NY 1 10
57. C.A. Santos Poly(fumaric-co-sebacic anhydride): a degradation study as evaluated by FTIR, DSC, GPC, and X-ray diffraction J. Control. Release 60 1999 11 22 (Pubitemid 29255825)
58. A.A. Mortazavi, and H.R. Moghimi The effect of hydroxyl containing tablet excipients on the adhesive duration of some mucoadhesive polymers DARU 12 2004 11 17 (Pubitemid 38821538)
59. M.J. Tobyn, J.R. Johnson, and P.W. Dettmar Factors affecting in vitro gastric mucoadhesion: influence of tablet excipients, surfactants and salts on the observed mucoadhesion of polymers Eur. J. Pharm. Biopharm. 43 1997 65 71 (Pubitemid 28298812)
60. A. Semalty, M. Semalty, R. Singh, S.K. Saraf, and S. Saraf Properties and formulation of oral drug delivery systems of protein and peptides Indian J. Pharm. Sci. 69 6 2007 741 747 (Pubitemid 351380185)
61. I.A. Siegel, K.T. Izutsu, and E. Watson Mechanisms of nonelectrolyte penetration across dog and rabbit oral mucosa in vitro Arch. Oral Biol. 26 1981 357 361 (Pubitemid 11085240)
62. J.R. Robinson, V.H. L. Lee. Controlled drug delivery: fundamentals and application: influence of drug properties on design CBS Publishers & Distributors pp 42.
63. S.K. Roy, and B. Prabhakar Bioadhesive polymeric platforms for transmucosal drug delivery systems-a review Tro. J. Pharm. Res. 9 1 2010 91 104
64. M.L. Bruschi, and O. de Freitas Oral bioadhesive drug delivery systems Drug Dev. Ind. Pharm. 31 3 2005 293 310 (Pubitemid 40463973)
65. S.B. Patil, R.S.R. Murthy, H.S. Mahajan, R.D. Wagh, and S.G. Gattani Mucoadhesive polymers: means of improving drug delivery Pharma Times 38 4 2006 25
66. N. Salamat-Miller, M. Chittchang, and T.P. Johnston The use of mucoadhesive polymers in buccal drug delivery Adv. Drug Deliv. Rev. 57 2005 1666 1691 (Pubitemid 41443474)
67. M.A. Longer, and J.R. Robinson Fundamental aspects of bioadhesion Pharm. Int. 7 1986 114 117 (Pubitemid 17183045)
68. H. Park, and J.R. Robinson Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels Pharm. Res. 4 1987 457 464
69. Y. Huang, W. Leobandung, A. Foss, and N.A. Peppas Molecular aspects of muco- and bioadhesion: tethered structures and site specific surfaces J. Control. Release 65 2001 63 71 (Pubitemid 30122916)
70. J.D. Smart, and S.A. Mortazavi An investigation into the role of water movement and mucus gel dehydration in mucoadhesion J. Control. Release 25 1993 197 203 (Pubitemid 23181331)
71. John D. Smart The basics and underlying mechanisms of mucoadhesion Adv. Drug Deliv. Rev. 57 2005 1556 1568 (Pubitemid 41443469)
72. A. Ganem-Quintanar Mechanisms of oral permeation enhancement Int. J. Pharm. 155 1997 127 142 (Pubitemid 27400001)
73. J. Hao, and P.S.W. Heng Buccal delivery systems Drug Dev. Ind. Pharm. 29 2003 821 832 (Pubitemid 37203684)
74. J. Hamman Enhancement of paracellular drug transport across mucosal epithelia by N-trimethyl chitosan chloride S.T.P. Pharm. Sci. 10 2000 35 38 (Pubitemid 30126783)
75. A. Bernkop-Schnurch Chitosan and its derivatives: potential excipients for peroral peptide delivery systems Int. J. Pharm. 194 2000 1 13
76. A.H. Shojaei Buccal mucosa as a route for systemic drug delivery: a review J. Pharm. Pharm. Sci. 1 1 1998 15 30
77. A. Bernkop-Schnürch Mucoadhesive systems in oral drug delivery Drug Discov. Today Technol. 2 1 2005
78. M.J. Rathbone, and I.G. Tucker Mechanisms, barriers and pathways of oral mucosal drug permeation Adv. Drug Deliv. Rev. 12 1993 41 60 (Pubitemid 23332997)
79. H. Zhang, J. Zhang, and J.B. Streisan Oral mucosal drug delivery clinical pharmacokinetics and therapeutic applications Clin. Pharmacokinet. 41 9 2002 661 680
80. P. Gilles, F.A. Ghazali, and J. Rathbone Systemic Oral Mucosal Drug Delivery Systems and Delivery Systems Oral Mucosal Drug Delivery 1996 Marcel Dekker Inc New York 241 285
81. L.L. Christrup, S.N. Rasmussen, and M.R. Rassing Chewing gum as a drug delivery system. IV. Excretion of ascorbic acid in urine after administration of chewing gum and chewing tablets Farm. Sci. Ed. 16 1988 44 67
82. L.N. Jensen, L.L. Christrup, N. Menger, and H. Bundgaard Chewing gum and lozenges as delivery systems for noscapine Acta Pharm. Nord. 3 1991 219 222 25
83. M.A.H. Russel, M. Raw, and M.J. Jarvis Clinical use of nicotine chewing gum Brit. Med. J. 280 1980 1599 1602
84. C. Graffner Some Clinical Results with Respect to Buccal Administration Minutes European Symposium on Buccal and Nasal Administration as an Alternative to Parenteral Administration, Paris, 10-11 Dec. 1991 1992 191 203
85. N.L. Benowitz, P. Jacob, and C. Savanapridi Determinants of nicotine intake while chewing nicotine polacrilex gum Clin. Pharmacol. Ther. 41 1987 467 473 (Pubitemid 17058934)
86. L.L. Christrup, J. Bonde, H. Eriksen, S.N. Rasmussen, M.R. Rassing, and K. Simonsen Bioavailability of salicylamide administered in tablets and chewing gum Farm. Sci. Ed. 16 1988 6 14
87. L.L. Christrup, J. Bonde, H. Eriksen, S.N. Rasmussen, and M.R. Rassing Relative bioavailability of (+/-)-verapamil hydrochloride administered in tablets and chewing gum Acta Pharm. Nord. 2 1990 371 376
88. J. Sanjay, and J. Anekant Target-specific drug release to the colon Exp. Opin. Drug Del. 5 5 2008 483 498
89. B.A. Burnside, A.D. Keith, and W. Snipes Microporous hollow fibers as a peptide delivery system via the buccal cavity Proc. Int. Symp. Control. Release Bioact. Mater. 16 1989 93 94
90. C.G. Wilson, and N. Washington Scintigraphic Studies of Nasal and Buccal Administration Minutes European Symposium on Buccal and Nasal Administration as an Alternative to Parenteral Administration, Paris Dec 10-11 1991 174 187 Editions de Sant6, Paris
91. C.G. Wilson, and N. Washington Drug Delivery to the Oral Cavity Physiological Pharmaceutics. Biological Barriers to Drug Absorption 1989 Ellis Horwood Chichester 21 36
92. M. Yamamoto, K. Okabe, J. Kubo, T. Naruchi, H. Ikura, Y. Suzuki, and T. Nagai The bioadhesive and residence properties and drug penetration effect of powders preparations for the oral cavity containing hydroxypropyl cellulose S.T.P. Pharm. 5 1989 878 885
93. S.P. Vyas, and C.P. Jain Bioadhesive polymer-grafted starch microspheres bearing isorbide dinitrate for buccal administration J. Microencapsul. 9 1992 457 464
94. G. Ponchel, and D. Duchne Development of a Bioadhesive Tablet M. Szycher, High Performance Biomaterials. A Comprehensive Guide to Medical and Pharmaceutical Applications, Technomic, Lancaster 1992 231 242
95. K.V. Ranga Rao, A. Ben-Amor, and P. Buri Studies on buccoadhesive tablet formulation of codeine phosphate S.T.P. Pharm. 5 1989 899 903 26
96. G. Ponchel, F. Touchard, D. Duchne, and N.A. Peppas Bioadhesive analysis of controlled release systems. I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systems J. Control. Release 5 1987 129 141 (Pubitemid 17132061)
97. N.A. Peppas, G. Ponchel, and D. Duchne Bioadhesive analysis of controlled-release systems. II. Time-dependent bioadhesive stress in poly(acrylic acid)-containing systems J. Control. Release 5 1987 143 149 (Pubitemid 17132062)
98. G. Ponchel, F. Touchard, D. Wouessidjewe, D. Duchne, and N.A. Peppas Bioadhesive analysis of controlled-release systems. III. Bioadhesive and release behavior of metronidazolecontaining poly(acrylic acid)-hydroxypropyl methylcellulose systems Int. J. Pharm. 38 1987 65 70 (Pubitemid 17148755)
99. F. Lejoyeux, G. Ponchel, and D. Duchne Influence of some technological parameters on the bioadhesive characteristics of poly(acrylic acid) matrices S.T.P. Pharm. 5 1989 893 898
100. J.D. Smart An evaluation of some mucosa-adhesive dosage forms for drug delivery to the oral cavity J. Pharm. Pharmacol. 42 1990 141
101. G. Ponchel Formulation of oral mucosal drug delivery systems for the systemic delivery of bioactive materials Adv. Drug Deliv. Rev. 13 1994 75 87 (Pubitemid 24032042)
102. W.G. Chen, and G.C. Hwang Adhesive and in vitro characteristics of propranolol bioadhesive disc system Int. J. Pharm. 82 1992 61 66
103. M.P. Danckewerts Intraoral drug delivery: a comparative review Am. J. Drug Del. 1 3 2003 1 16
104. O. Kislal, and N. Celebi Studies on bioadhesive tablet formulation of propranolol HCI Proc. Int. Symp. Control. Release Bioact. Mater. 19 1992 397 398
105. P.B. Deasy, and C.T. O'Neill Bioadhesive dosage form for peroral administration oftimolol base Pharm. Acta Helv. 64 1989 231 235 (Pubitemid 19205720)
106. N. Garcia-Gonzalez, H. Blanco-Fuente, S. Anguiano-Igea, B. Delgado-Charro, F.J. Otero-Espinar, and J. Blanco-Mendez In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose S.T.P. Pharm. Sci. 2 1992 494 499 (Pubitemid 23012600)
107. T. Nagai, and P. Konishi Buccal/gingival drug delivery systems J. Control. Release 6 1987 353 360 (Pubitemid 18017744)
108. J.M. Schor, S.S. Davis, A. Nigalaye, and S. Bolton Susadrin transmucosal tablets Drug Dev. Ind. Pharm. 9 1983 1359 1377
109. S. Anlar, Y. Capan, and A.A. Hincal Studies on buccoadhesive tablet formulation of morphine sulfate 6th Int. Conf. Technol. Pharm. Paris 24 June 2 1992 30 39 27
110. I.W. Kellaway, and S.J. Warren Mucoadhesive hydrogels Proc. Int. Symp. Control. Release Bioact. Mater. 18 1991 73 74
111. S.J. Warren, I.W. Kellaway, and P. Timmins Mucoadhesive hydrogels for buccal delivery of peptides Proc. Int. Symp. Control. Release Bioact. Mater. 16 1989 402 403
112. Kellaway, and P. Timmins Hydrogels for Buccal Administration Minutes European Symposium on Buccal and Nasal Administration as an Alternative to Parenteral Administration, Paris, 10 11 Dec. 1991, Editions de Sant6, Paris 1992 101 109
113. M.E. De Vries, H.E. Bodd, H.J. Busscher, and H.E. Junginger Hydrogels for buccal drug delivery: properties relevant for muco-adhesion J. Biomed. Mater. Res. 22 1988 1023 1032
114. M.E. De Vries, H.E. Bodd, A. Nascimento, H.J. Busscher, and H.E. Junginger Mucoadhesive polyacrylic hydrogels for buccal drug delivery. Copolymers compared with polymer mixtures S.T.P. Pharm. 5 1989 847 851
115. B. Yang, and K. Knutson Buccal delivery system for polar solutes Proc. Int. Symp. Control. Release Bioact. Mater. 19 1992 409 410
116. J. Cassidy, B. Berner, K. Chan, V. John, S. Toon, B. Holt, and M. Rowland Buccal delivery of diclofenac sodium in man using a prototype hydrogel delivery device Proc. Int. Symp. Control. Release Bioact. Mater. 16 1989 91 92
117. Y. Kurosaki, T. Takatori, M. Kitayama, T. Nakayama, and T. Kimura Application of propranolol to the keratinized oral mucosa: avoidance of first-pass elimination and the use of 1-dodecylazacycloheptan-2-one (Azone) as an absorption enhancer of bioadhesive film-dosage form J. Pharmacobiodyn. 11 1988 824 832 (Pubitemid 19036199)
118. B. Rodu, C.M. Russell, and A.J. Desmarais Clinical and chemical properties of a novel mucosal bioadhesive agent J. Oral Pathol. 17 1988 564 567
119. H.P. Merkle, and G.J.M. Wolany Muco-adhesive Patches for Buccal Peptide Administration Minutes European Symposium on Buccal and Nasal Administration as an Alternative to Parenteral Administration, Paris, 10 11 Dec. 1991 1992 116 124 Editions de Sant6, Paris
120. M.A. Hussain, B.J. Aungst, C.A. Koval, and E. Shelter Improved buccal delivery of opioids analgesics and antagonists with bitterless prodrugs Pharm. Res. 5 1988 615 618
121. M.M. Veillard, M.A. Longer, T.W. Martens, and J.R. Robinson Preliminary studies of oral mucosal delivery of peptide drugs J. Control. Release 6 1987 123 131 (Pubitemid 18017728)
122. R. Anders, and H.P. Merkle Evaluation of laminated mucoadhesive patches for buccal drug delivery Int. J. Pharm. 49 1989 231 240 (Pubitemid 19053414)
123. H.P. Merkle, and G. Wolany Buccal delivery of peptide drugs J. Control. Release 21 1992 155 164 28