Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway

Chemico-Biological Interactions

Volumn 190, Issue 2-3, 2011, Pages 91-101

  Liu, Jin Yun ^a   Liu, Zhong ^b   Wang, Dong Mei ^a   Li, Man Mei ^b   Wang, Shao Xiang ^b   Wang, Rui ^b   Chen, Jian Ping ^c   Wang, Yi Fei ^b   Yang, De Po ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Antitumor activity; Apoptosis; Hyperforin derivatives; K562 cells

Indexed keywords

BIM PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOCHROME C; HYPERFORIN; HYPERFORIN DICYCLOHEXYLAMMONIUM SALT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN BOK; PROTEIN P53; PUMA PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYTOCHROMES C; DNA FRAGMENTATION; G1 PHASE; HUMANS; HYPERICUM; K562 CELLS; MITOCHONDRIA; PHLOROGLUCINOL; SIGNAL TRANSDUCTION; TERPENES; TUMOR SUPPRESSOR PROTEIN P53;

HYPERICUM PERFORATUM;

EID: 79955474334     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.02.026     Document Type: Article

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