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Volumn 19, Issue 9, 2011, Pages 2991-2996
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Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development
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Author keywords
Aminopeptidase N; Crystal structure; Drug design; Inhibitors; Tricorn interacting factor F3
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Indexed keywords
ANTINEOPLASTIC AGENT;
BACTERIAL ENZYME;
COMPOUND D24;
MICROSOMAL AMINOPEPTIDASE;
N6 [(BENZYLOXY) CARBONYL] N2 (2,4 DICHLOROBENZOYL) N1 HYDROXY LYSINAMIDE;
TRICORN INTERACTING FACTOR F3;
UNCLASSIFIED DRUG;
ARTICLE;
BINDING AFFINITY;
CONTROLLED STUDY;
CRYSTALLIZATION;
DRUG DESIGN;
DRUG POTENCY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
ENZYME INHIBITION;
NONHUMAN;
POINT MUTATION;
PROTEIN BINDING;
SEQUENCE ALIGNMENT;
SEQUENCE HOMOLOGY;
THERMOPLASMA ACIDOPHILUM;
THERMOSTABILITY;
AMINO ACID SEQUENCE;
ANTIGENS, CD13;
ANTINEOPLASTIC AGENTS;
ARCHAEAL PROTEINS;
BINDING SITES;
CATALYTIC DOMAIN;
COMPUTER SIMULATION;
CRYSTALLOGRAPHY, X-RAY;
DRUG DESIGN;
ENZYME INHIBITORS;
HUMANS;
KINETICS;
MOLECULAR SEQUENCE DATA;
MUTATION;
ORGANOMETALLIC COMPOUNDS;
PROTEIN ENGINEERING;
PROTEIN STRUCTURE, TERTIARY;
SEQUENCE ALIGNMENT;
SEQUENCE HOMOLOGY, AMINO ACID;
THERMOPLASMA;
ZINC;
ESCHERICHIA COLI;
MAMMALIA;
THERMOPLASMA ACIDOPHILUM;
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EID: 79955467330
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2011.03.028 Document Type: Article |
Times cited : (8)
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References (27)
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