Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2775-2784

  Shang, Luqing ^a   Fang, Hao ^a   Zhu, Huawei ^a   Wang, Xuejian ^a   Wang, Qiang ^a   Mu, Jiajia ^a   Wang, Binghe ^b   Kishioka, Shiroh ^c   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b GEORGIA STATE UNIVERSITY   (United States)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

3 Phenylpropane 1,2 diamine; Aminopeptidase N inhibitor; Synthesis; Tripeptide analogs

Indexed keywords

3 PHENYLPROPANE 1,2 DIAMINE; ALANYL N 1 (2 AMINO 3 PHENYLPROPYL)LEUCINAMIDE; BESTATIN; CYSTEINYL N (2 AMINO 3 PHENYLPROPYL)PHENYLALANINAMIDE; CYSTEINYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; DIAMINE DERIVATIVE; ENZYME INHIBITOR; GLYCYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; GLYCYL N 1 (2 AMINO 3 PHENYLPROPYL)LEUCINAMIDE; ISOLEUCYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; ISOLEUCYL N 1 (2 AMINO 3 PHENYLPROPYL)LEUCINAMIDE; LEUCYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; LEUCYL N 1 (2 AMINO 3 PHENYLPROPYL)LEUCINAMIDE; LEUCYL N 1 (2 AMINO 3 PHENYLPROPYL)PHENYLALANINAMIDE; LYSYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; LYSYL N 1 (2 AMINO 3 PHENYLPROPYL)PHENYLALANINAMIDE; METHIONYL N (2 AMINO 3 PHENYLPROPYL)PHENYLALANINAMIDE; METHIONYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; METHIONYL N 1 (2 AMINO 3 PHENYLPROPYL)LEUCINAMIDE; MICROSOMAL AMINOPEPTIDASE; N 1 (2 AMINO 3 PHENYLPROPYL) N (3,5 DINITROBENZOYL)PHENYLALANINAMIDE; N 1 (2 AMINO 3 PHENYLPROPYL) N (4 NITROBENZOYL)PHENYLALANINAMIDE; N 1 (2 AMINO 3 PHENYLPROPYL) N (6 AMINOHEXANOYL)LEUCINAMIDE; N 1 (2 AMINO 3 PHENYLPROPYL) N (6 AMINOHEXANOYL)PHENYLALANINAMIDE; ORNITHYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; PHENYLALANYL N (2 AMINO 3 PHENYLPROPYL)PHENYLALANINAMIDE; PHENYLALANYL N 1 (2 AMINO 3 PHENYLPROPYL)CYSTEINAMIDE; TRIPEPTIDE DERIVATIVE; TYROSYL N 1 (2 AMINO 3 PHENYLPROPYL)LEUCINAMIDE; UNCLASSIFIED DRUG; VALYL N (2 AMINO 3 PHENYLPROPYL)PHENYLALANINAMIDE;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ANTIGENS, CD13; CELL LINE, TUMOR; COMPUTER SIMULATION; DIAMINES; DRUG DESIGN; HL-60 CELLS; HUMANS; PEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62949135993     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.034     Document Type: Article

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