Involvement of DMT1 +IRE in the transport of lead in an in vitro BBB model

Toxicology in Vitro

Volumn 25, Issue 4, 2011, Pages 991-998

  Wang, Qiang ^a,b,c   Luo, Wenjing ^a   Zhang, Wenbin ^a   Liu, Mingchao ^a   Song, Haifeng ^b   Chen, Jingyuan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Blood brain barrier; Divalent metal transporter 1; Lead

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE MA1; DEFEROXAMINE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; IRON; LEAD; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC RESISTANCE; EXPOSURE; EXPRESSION VECTOR; GENETIC TRANSFECTION; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IRON DEPLETION; IRON RESPONSIVE ELEMENT; NONHUMAN; RAT; TOXICITY TESTING; TRANSENDOTHELIAL ELECTRIC RESISTANCE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CELLS, CULTURED; COCULTURE TECHNIQUES; DEXTRANS; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; FLUORESCEIN-5-ISOTHIOCYANATE; GLIOMA; HUMANS; LEAD; MODELS, BIOLOGICAL; PERMEABILITY; PROTEIN ISOFORMS; RATS; UMBILICAL VEINS;

RATTUS;

EID: 79955466813     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.11.006     Document Type: Article

References (25)

1. Arredondo M., Muñoz P., Mura C.V., Nùñez M.T. DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells. Am. J. Physiol. Cell. Physiol. 2003, 284:C1525-C1530.
2. Canfield R.L., Henderson C.R., Henderson D.A., Cory-Slechta C., Cox C., Jusko T.A., Lanphear B.P. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. New Engl. J. Med. 2003, 348:1517-1526.
3. Gu C., Chen S., Xu X., Zheng L., Li Y., Wu K., Liu J., Qi Z., Han D., Chen G., Huo X. Lead and cadmium synergistically enhance the expression of divalent metal transporter 1 protein in central nervous system of developing rats. Neurochem. Res. 2009, 34:1150-1156.
4. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., Hediger M.A. Cloning and characterization of a mammalian protoncoupled metal-ion transporter. Nature 1997, 388:482-488.
5. Hurst R.D., Fritz I.B. Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier. J. Cell. Physiol. 1996, 167:81-88.
6. Kato J., Kobune M., Ohkubo S., Fujikawa K., Tanaka M., Takimoto R., Takada K., Takahari D., Kawano Y., Kohgo Y., Niitsu Y. Iron/IRP-1-dependent regulation of mRNA expression for transferring receptor, DMT1 and ferreting during human erythroid differentiation. Exp. Hematol. 2007, 35:879-887.
7. Lee P.L., Gelbart T., West C., Halloran C., Beutler E. The human Nramp2 gene: characterization of the gene structure alternative splicing, promoter region and polymorphisms. Blood Cells Mol. Dis. 1998, 24:199-215.
8. Moos T., Skjoerringe T., Gosk S., Morgan E.H. Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferring without the involvement of divalent metal transporter 1. J. Neurochem. 2006, 98:1946-1958.
9. Muwakkit S., Nuwayhid I., Nabulsi M., Al Hajj R., Khoury R., Mikati M., Abboud M.R. Iron deficiency in young Lebanese children: association with elevated blood lead levels. J. Pediatr. Hematol. Oncol. 2008, 30:382-386.
10. Neuhaus W., Wirth M., Plattner V.E., Germann B., Gabor F., Noe C.R. Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media. Neurosci. Lett. 2008, 446:59-64.
11. Ong W.Y., He X., Chua L.H., Ong C.N. Increased uptake of divalent metals lead and cadmium into the brain after kainite-induced neuronal injury. Exp. Brain Res. 2000, 173:468-474.
12. Rossi E. Low level environmental lead exposure - a continuing challenge. Clin. Biochem. Rev. 2008, 29:63-70.
13. Roth J.A., Horbinski C., Feng L., Dolan K.G., Higgins D., Garrick M.D. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. J. Neurosci. 2000, 20:7595-7601.
14. Roth J.A., Feng L., Dolan K.G., Lis A., Garrick M.D. Effect of the iron chelator desferrioxamine on manganese-induced toxicity of rat pheochromocytoma (PC12) cells. J. Neurosci. Res. 2002, 68:76-83.
15. Rubin L.L., Staddon J.M. The cell biology of the blood-brain barrier. Annu. Rev. Neurosci. 1999, 22:11-28.
16. Scism J.L., Laska D.A., Horn J.W., Gimple J.L., Pratt S.E., Shepard R.L., Dantzig A.H., Wrighton S.A. Evaluation of an in vitro coculture model for the blood-brain barrier: comparison of human umbilical vein endothelial cells (ECV304) and rat glioma cells (C6) from two commercial sources. In Vitro Cell. Dev. Biol. Anim. 1999, 35:580-592.
17. Struzyńska L., Walski M., Gadamski R., Dabrowska-Bouta B., Rafałowska U. Lead-induced abnormalities in blood-brain barrier permeability in experimental chronic toxicity. Mol. Chem. Neuropathol. 1997, 31:207-224.
18. Tan K.H., Dobbie M.S., Felix R.A., Barrand M.A., Hurst R.D. A comparison of the induction of immortalized endothelial cell impermeability by astrocytes. NeuroReport 2001, 12:1329-1334.
19. Tchernitchko D., Bourgeois M., Martin M.E., Beaumont C. Expression of the two mRNA isoforms of the iron transporter Nrmap2/DMTI in mice and function of the iron responsive element. Biochem. J. 2002, 363:449-455.
20. Toews A.D., Kolber A., Hayward J., Krigman M.R., Morell P. Experimental lead encephalopathy in the suckling rat: concentration of lead in cellular fractions enriched in brain capillaries. Brain Res. 1978, 147:131-138.
21. Vivante A., Hirshoren N., Shochat T., Merkel D. Association between acute lead exposure in indoor firing ranges and iron metabolism. Israel Med. Assoc. J. 2008, 10:292-295.
22. Wakefield J. The lead effect?. Environ. Health Perspect. 2002, 110:A574-A580.
23. Wang Q., Luo W., Zheng W., Liu Y., Xu H., Zheng G., Da Z., Zhang W., Chen Y., Chen J. Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development. Toxicol. Appl. Pharmacol. 2007, 219:33-41.
24. Yeh W.L., Lu D.Y., Lin C.J., Liou H.C., Fu W.M. Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression. Mol. Pharmacol. 2007, 72:440-449.
25. Youdim K.A., Dobbie M.S., Kuhnle G., Proteggente A.R., Abbott N.J., Rice-Evans C. Interaction between flavonoids and the blood-brain barrier: in vitro studies. J. Neurochem. 2003, 85:180-192.