Effect of the iron chelator desferrioxamine on manganese-induced toxicity of rat pheochromocytoma (PC12) cells

Journal of Neuroscience Research

Volumn 68, Issue 1, 2002, Pages 76-83

  Roth, Jerome A ^a   Feng, Li ^a   Dolan, Kevin G ^a   Lis, Agnieszka ^a   Garrick, Michael D ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Desferrioxamine; Divalent metal transporter 1; DMT1; Iron transport; Nramp2; PC12 cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; DEFEROXAMINE; IRON CHELATING AGENT; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE 1; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IC 50; IRON CHELATION; IRON RESPONSIVE ELEMENT; IRON TRANSPORT; MITOCHONDRION; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; DEFEROXAMINE; IRON CHELATING AGENTS; MANGANESE; MANGANESE POISONING; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; RATS;

EID: 0036218892     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10207     Document Type: Article

References (39)

1. Cellular distribution of iron in the brain of the Belgrade rat
2. Separate pathways for cellular uptake of ferric and ferrous iron
3. The health implications of increased manganese in the environment resulting from the combustion of fuel additives: A review of the literature
4. Fluorescence analysis of the labile iron pool of mammalian cells
5. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
6. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
7. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1
8. Vulnerability of mitochondrial complex 1 in PC12 cells exposed to manganese
9. Iron supplementation moderates but does not cure the Belgrade anemia
10. An expression system for a transporter of iron and other metals
11. 2+ sequestration by mitochondria and inhibition of oxidative phosphorylation
12. Manganese and calcium transport in mitochondria: Implications for manganese toxicity
13. Occupational exposure to manganese, copper, lead, iron, mercury, and zinc and the risk of Parkinson's disease
14. Identification and characterization of a second mouse Nramp gene
15. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
16. Regulation of genes of iron metabolism by the iron-response proteins
17. Manganese intoxication and chronic liver failure
18. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease
19. Activation of PNK pathway and induction of apoptosis by manganese in PC12 cells
20. Effects from environmental Mn exposures: A review of the evidence from nonoccupational exposure studies
21. Manganese transport and Na/K/Cl cotransport in PC-12 cells
22. Manganese and chronic hepatic encephalopathy
23. Chronic marginal iron intakes during early development in mice result in persistent changes in dopamine metabolism and myelin composition
24. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
25. The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region, and polymorphisms
26. Manganese induces spreading and neurite process outgrowth in rat pheochromocytoma
27. Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases
28. Existing and emerging mechanisms for transport of iron and manganese to the brain
29. Manganese neurotoxicity: A review of clinical features, imaging, and pathology
30. Increased manganese concentrations in pallidum of cirrhotic patients
31. Differential localization of divalent metal transporter (DMT1) with and without iron response element (IRE) in rat PC12 and sympathetic neuronal cells
32. Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation
33. Manganese induces apoptosis of human B cells: Caspase-dependent cell death blocked by Bcl-2
34. Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa: Possible implications for the regulation of iron absorption
35. Iron involvement in neuronal damage and microgliosis in models of neurodegenerative diseases
36. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells
37. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficient, but to hepatocytes in iron overload
38. Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells
39. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis