Simultaneous detection of N-acetyl-l-cysteine and physiological low molecular mass thiols in plasma by capillary electrophoresis

Amino Acids

Volumn 37, Issue 2, 2009, Pages 395-400

  Zinellu, Angelo ^a,b   Sotgia, Salvatore ^a,b   Scanu, Bastianina ^a,b   Usai, Maria Franca ^a   Fois, Alessandro Giuseppe ^a   Spada, Valentina ^a   Deledda, Anna ^a   Deiana, Luca ^a   Pirina, Piero ^a   Carru, Ciriaco ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

Capillary electrophoresis; LMW thiols; NAC

Indexed keywords

ACETYLCYSTEINE; BORIC ACID; CYSTEINE; GLUTATHIONE; HOMOCYSTEINE; MEGLUMINE; MUCOLYTIC AGENT; SODIUM DIHYDROGEN PHOSPHATE; THIOL DERIVATIVE;

ARTICLE; CAPILLARY ELECTROPHORESIS; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MECHANISM; DRUG METABOLISM; HUMAN; HYPERHOMOCYSTEINEMIA; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; REPRODUCIBILITY;

ACETYLCYSTEINE; ELECTROPHORESIS, CAPILLARY; EXPECTORANTS; HUMANS; MOLECULAR WEIGHT; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SULFHYDRYL COMPOUNDS;

EID: 67650727394     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-008-0167-x     Document Type: Article

References (34)

1. W Baeyens G Van der Weken B Ling PDe Moerloose 1988 HPLC determination of N-acetylcysteine in pharmaceutical preparations after precolumn derivatization with thiolyte MB using fluorescence detection Anal Lett 21 741 757 (Pubitemid 18133868)
2. W Barnner Jr M Koch DM Capin 1986 Experimental chelation therapy in chromium, lead, and boron intoxication with N acetylcysteine and other compounds Toxicol Appl Pharmacol 83 142 147 (Pubitemid 16113514)
3. G Boban U Bäcker S Larsson B Melander L Wahlinder 1983 Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish society for pulmonary diseases Eur J Respir Dis 64 405 441
4. IA Cotgreave P Moldeus 1987 Methodologies for the analysis of reduced and oxidized N-acetylcysteine in biological systems Biopharm Drug Dispos 8 365 375 (Pubitemid 17114983)
5. A D'Angelo J Selhub 1997 Homocysteine and thrombotic disease Blood 90 1 11 (Pubitemid 27276540)
6. S De Flora C Bennicelli A Camoirano D Serra M Romano GA Rossi A Morelli A De Flora 1985 In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenics and/or mutagenic compounds Carcinogenesis 6 1735 1745 (Pubitemid 16168985)
7. N De Vries S De Flora 1993 N-Acetyl-l-cysteine J Cell Biochem 17 270 277 (Pubitemid 23252953)
8. C Dette H Wätzig 1994 Separation of enantiomers of N-acetylcysteine by capillary electrophoresis after derivatization by o-phthaldialdehyde Electrophoresis 15 763 768 (Pubitemid 24204972)
9. N Ercal S Oztezcan TC Hammond R Matthews DR Spitz 1996 High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide J Chromatogr B 685 329 334 (Pubitemid 26382415)
10. KA Hajjar 2001 Homocysteine: a sulph'rous fire J Clin Invest 107 663 664 (Pubitemid 32225349)
11. B Hultberg A Andersson P Masson M Larsson A Tunek 1994 Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine Scand J Clin Lab Invest 54 417 422 (Pubitemid 24308982)
12. M Jaworska G Szulinska M Wilk J Tautt 1999 Capillary electrophoretic separation of N-acetylcysteine and its impurities as a method for quality control of pharmaceuticals J Chromatogr A 853 479 485 (Pubitemid 29376632)
13. D Lapenna S de Gioia G Ciofani A Mezzetti S Ucchino AM Calafiore AM Napoletano C Di Ilio F Cuccurullo 1998 Glutathione-related antioxidant defenses in human atherosclerotic plaques Circulation 97 1930 1934 (Pubitemid 28222187)
14. KS McCully 1969 Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis Am J Pathol 56 111 128
15. P Moldéus IA Cotgreave M Berggren 1986 Lung protection by a thiol-containing antioxidant: N-acetylcysteine Respiration 50 31 42 (Pubitemid 17181836)
16. JA Morrison DW Jacobsen DL Sprecher K Robinson P Khoury SR Daniels 1999 Serum glutathione in adolescent males predicts parental coronary heart disease Circulation 100 2244 2247
17. JS Murley Y Kataoka D Cao JJ Li LW Oberley DJ Grdina 2004 Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs Radiat Res 162 536 546 (Pubitemid 39600542)
18. K Nakata M Kawase S Ogino C Kinoshita H Murata T Sakaue K Ogata S Ohmori 1996 Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione levels of mouse with cysteine derivatives Mech Ageing Dev 90 195 207 (Pubitemid 26331619)
19. B Olsson M Johansson J Gabrielsson P Bolme 1988 Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine Eur J Clin Pharmacol 34 77 82 (Pubitemid 18079472)
20. H Ottenwälder P Simon 1987 Differential effect of N-acetylcysteine on excretion of the metals Hg, Cd, Pb and Au Arch Toxicol 60 401 402 (Pubitemid 17137315)
21. Y Ozkan E Ozkan B Simsek 2002 A high-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrennyl)maleimide Int J Card 82 269 277
22. LF Prescott A Ballantyne J Park P Adrieiaenssens AT Proufoot 1977 Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine Lancet 2 432 434 (Pubitemid 8167941)
23. LF Prescott RN Illingworth JAJH Critchley MJ Stewart RD Adam AT Proudfoot 1979 Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning Br Med J 2 1097 1100 (Pubitemid 10249121)
24. B Särnstrand A Tunek K Sjödin A Hallberg 1995 Effects of N-acetylcysteine stereoisomers on oxygen-inducedlung injury in rats Chem Biol Interact 94 157 164
25. P Sheiner W De Mayo GA Levy 1992 Acetylcysteine and fulminant hepatic failure Hepatology 15 552 554
26. MJ Smilkstein GL Knapp KW Kulig BH Rumack 1988 Efficacy of N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985) N Engl J Med 319 1557 1562 (Pubitemid 19003420)
27. M Spotheim-Maurizot F Garnier C Kieda R Sabattier M Charlier 1993 N-acetylcysteine and captopril protect DNA and cells against radiolysis by fast neutrons Radiat Environ Biophys 32 337 343 (Pubitemid 23362688)
28. D Tsikas J Sandmann M Ikic J Fauler DO Stichtenoth JC Frölich 1998 Analysis of cysteine and N-acetylcysteine in human plasma by high-performance liquid chromatography at the basal state and after oral administration of N-acetylcysteine J Chromatogr B 708 55 60 (Pubitemid 28239888)
29. P Ventura R Panini MC Pasini G Scarpetta G Salvioli 1999 N-Acetyl-cysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion Pharm Res 40 345 350 (Pubitemid 29472062)
30. O Wiklund G Fager A Andersson U Lundstam P Masson B Hultberg 1996 N-Acetylcysteine treatmentlowers plasma homocysteine but not serum lipoprotein(a) levels Atherosclerosis 119 99 106 (Pubitemid 26020672)
31. I Ziment 1986 Acetylcysteine: a drug with and an interesting past and a fascinating future Respiration 50 26 30 (Pubitemid 17181835)
32. A Zinellu C Carru F Galistu MF Usai GM Pes G Baggio G Federici L Deiana 2003 N-methyl-d-glucamine improves the laser-induced fluorescence capillary electrophoresis performance in the total plasma thiols measurement Electrophoresis 24 2796 2804 (Pubitemid 38089072)
33. A Zinellu A Pinna E Zinellu S Sotgia L Deiana C Carru 2008 High-throughput capillary electrophoresis method for plasma cysteinylglycine measurement: evidences for a clinical application Amino Acids 34 69 74
34. J Perla-Kajan T Twardowski H Jakubowski 2007 Mechanisms of homocysteine toxicity in humans Amino Acids 32 561 572 (Pubitemid 46790938)