A 128-base-pair sequence containing the pac1 and a presumed cryptic pac2 sequence includes cis elements sufficient to mediate efficient genome maturation of human cytomegalovirus

Journal of Virology

Volumn 85, Issue 9, 2011, Pages 4432-4439

  Wang, Jian Ben ^a   McVoy, Michael A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYADENYLIC ACID; VIRUS DNA;

ARTICLE; BASE PAIRING; BINDING SITE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA CLEAVAGE; DNA SEQUENCE; GENE SEQUENCE; HERPES VIRUS; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PAC1 GENE; PAC2 GENE; PRIORITY JOURNAL; PROTEIN MOTIF; SIGNAL TRANSDUCTION; VIRAL GENETICS; VIROGENESIS; VIRUS GENE; VIRUS GENOME;

CYTOMEGALOVIRUS; DNA, VIRAL; HUMANS; VIRUS ASSEMBLY;

HERPESVIRIDAE; HUMAN HERPESVIRUS 5; MIRIDAE; MURID HERPESVIRUS 1;

EID: 79955458682     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02307-10     Document Type: Article

References (40)

1. Adelman, K., B. Salmon, and J. D. Baines. 2001. Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery. Proc. Natl. Acad. Sci. U. S. A. 98:3086-3091.
2. Bogner, E., K. Radsak, and M. F. Stinski. 1998. The gene product of human cytomegalovirus open reading frame UL56 binds the pac motif and has specific nuclease activity. J. Virol. 72:2259-2264.
3. Brown, J. C., M. A. McVoy, and F. L. Homa. 2002. Packaging DNA into herpesvirus capsids.p. 111-153. In E. Bogner and A. Holzenburg (ed.), Structure-function relationships of human pathogenic viruses. Kluwer Academic/Plenum Publishers, London, United Kingdom.
4. Buerger, I., et al. 2001. A novel nonnucleoside inhibitor specifically targets cytomegalovirus DNA maturation via the UL89 and UL56 gene products. J. Virol. 75:9077-9086.
5. Chowdhury, S. I., H. J. Buhk, H. Ludwig, and W. Hammerschmidt. 1990. Genomic termini of equine herpesvirus 1. J. Virol. 64:873-880.
6. Davison, A. J. 1984. Structure of the genome termini of varicella-zoster virus. J. Gen. Virol. 65:1969-1977.
7. Deiss, L. P., J. Chou, and N. Frenkel. 1986. Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA. J. Virol. 59:605-618.
8. Deiss, L. P., and N. Frenkel. 1986. Herpes simplex virus amplicon: cleavage of concatemeric DNA is linked to packaging and involves amplification of the terminally reiterated a sequence. J. Virol. 57:933-941.
9. Ebeling, A., G. M. Keil, E. Knust, and U. H. Koszinowski. 1983. Molecular cloning and physical mapping of murine cytomegalovirus DNA. J. Virol. 47:421-433.
10. Hahn, G., M. Jarosch, J. B. Wang, C. Berbes, and M. A. McVoy. 2003. Tn7-mediated introduction of DNA sequences into bacmid-cloned cytomeg-alovirus genomes for rapid recombinant virus construction. J. Virol. Methods 107:185-194.
11. Hammerschmidt, W., H. Ludwig, and H. J. Buhk. 1988. Specificity of cleavage in replicative-form DNA of bovine herpesvirus 1. J. Virol. 62:1355-1363.
12. Hodge, P. D., and N. D. Stow. 2001. Effects of mutations within the herpes simplex virus type 1 DNA encapsidation signal on packaging efficiency. J. Virol. 75:8977-8986.
13. Hwang, J. S., et al. 2007. Identification of acetylated, tetrahalogenated benz-imidazole D-ribonucleosides with enhanced activity against human cytomeg-alovirus. J. Virol. 81:11604-11611.
14. Kaufer, B. B., B. Smejkal, and N. Osterrieder. 2010. The varicella-zoster virus ORFS/L (ORF0) gene is required for efficient viral replication and contains an element involved in DNA cleavage. J. Virol. 84:11661-11669.
15. Kemble, G. W., and E. S. Mocarski. 1989. A host cell protein binds to a highly conserved sequence element (pac-2) within the cytomegalovirus a sequence. J. Virol. 63:4715-4728.
16. Kilpatrick, B. A., and E. S. Huang. 1977. Human cytomegalovirus genome: partial denaturation map and organization of genome sequences. J. Virol. 24:261-276.
17. Krosky, P. M., et al. 1998. Resistance of human cytomegalovirus to benz-imidazole ribonucleosides maps to two open reading frames: UL89 and UL56. J. Virol. 72:4721-4728.
18. LaFemina, R. L., and G. S. Hayward. 1980. Structural organization of the DNA molecules from human cytomegalovirus, p. 39-55. In B. N. Fields and R. Jaenisch (ed.), Animal virus genetics. Academic Press, New York, NY.
19. Lischka, P., and H. Zimmermann. 2008. Antiviral strategies to combat cytomegalovirus infections in transplant recipients. Curr. Opin. Pharmacol. 8:541-548.
20. McVoy, M. A., and D. E. Nixon. 2005. Impact of 2-bromo-5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole riboside and inhibitors of DNA, RNA, and protein synthesis on human cytomegalovirus genome maturation. J. Virol. 79:11115-11127.
21. McVoy, M. A., D. E. Nixon, and S. P. Adler. 1997. Circularization and cleavage of guinea pig cytomegalovirus genomes. J. Virol. 71:4209-4217.
22. McVoy, M. A., D. E. Nixon, S. P. Adler, and E. S. Mocarski. 1998. Sequences within the herpesvirus-conserved pac1 and pac2 motifs are required for cleavage and packaging of the murine cytomegalovirus genome. J. Virol. 72:48-56.
23. McVoy, M. A., D. E. Nixon, J. K. Hur, and S. P. Adler. 2000. The ends on herpesvirus DNA replicative concatemers contain pac2 cis cleavage/packaging elements and their formation is controlled by terminal cis sequences. J. Virol. 74:1587-1592.
24. Mercer, J. A., J. R. Marks, and D. H. Spector. 1983. Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith strain). Virology 129:94-106.
25. Mocarski, E. S., A. C. Liu, and R. R. Spaete. 1987. Structure and variability of the a sequence in the genome of human cytomegalovirus (Towne strain). J. Gen. Virol. 68:2223-2230.
26. Nasseri, M., and E. S. Mocarski. 1988. The cleavage recognition signal is contained within sequences surrounding an a-a junction in herpes simplex virus DNA. Virology 167:25-30.
27. Roizman, B., and P. E. Pellett. 2001. The family of Herpesviridae: a brief introduction, p. 2381-2397. In D. M. Knipe and P. M. Howley (ed.), Fields virology. Lippincott Williams and Wilkins, Philadelphia, PA.
28. Roizman, B., and A. E. Sears. 1996. Herpes simplex viruses and their replication, p. 1048-1066. In B. N. Fields et al. (ed.), Fundamental virology. Raven Press, New York, NY.
29. Sauer, A., J. B. Wang, G. Hahn, and M. A. McVoy. 2010. A human cytomegalovirus deleted of internal repeats replicates with near wild type efficiency but fails to undergo genome isomerization. Virology 401: 90-95.
30. Schynts, F., et al. 2003. The structures of bovine herpesvirus 1 virion and concatemeric DNA: implications for cleavage and packaging of herpesvirus genomes. Virology 314:326-335.
31. Smiley, J. R., J. Duncan, and M. Howes. 1990. Sequence requirements for DNA rearrangements induced by the terminal repeat of herpes simplex virus type 1 KOS DNA. J. Virol. 64:5036-5050.
32. Tamashiro, J. C., D. Filpula, T. Friedmann, and D. H. Spector. 1984. Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169 DNA. J. Virol. 52:541-548.
33. Tamashiro, J. C., and D. H. Spector. 1986. Terminal structure and heterogeneity in human cytomegalovirus strain AD169. J. Virol. 59:591- 604.
34. Tong, L., and N. D. Stow. 2010. Analysis of herpes simplex virus type 1 DNA packaging signal mutations in the context of the viral genome. J. Virol. 84:321-329.
35. Underwood, M. R., et al. 2004. Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus. Antimicrob. Agents Chemother. 48:1647-1651.
36. Underwood, M. R., et al. 1998. Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product. J. Virol. 72:717-725.
37. van Zeijl, M., et al. 2000. Novel class of thiourea compounds that inhibit herpes simplex virus type 1 DNA cleavage and encapsidation: resistance maps to the UL6 gene. J. Virol. 74:9054-9061.
38. Varmuza, S. L., and J. R. Smiley. 1985. Signals for site-specific cleavage of HSV DNA: maturation involves two separate cleavage events at sites distal to the recognition sequences. Cell 41:793-802.
39. Wang, J. B., D. E. Nixon, and M. A. McVoy. 2008. Definition of the minimal cis-acting sequences necessary for genome maturation of the herpesvirus murine cytomegalovirus. J. Virol. 82:2394-2404.
40. Zimmermann, J., and W. Hammerschmidt. 1995. Structure and role of the terminal repeats of Epstein-Barr virus in processing and packaging of virion DNA. J. Virol. 69:3147-3155.