Sequences within the herpesvirus-conserved pac1 and pac2 motifs are required for cleavage and packaging of the murine cytomegalovirus genome

Journal of Virology

Volumn 72, Issue 1, 1998, Pages 48-56

  McVoy, Michael A ^a   Nixon, Daniel E ^a   Adler, Stuart P ^a   Mocarski, Edward S ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CYTOMEGALOVIRUS; DNA CLEAVAGE; DNA FLANKING REGION; DNA PACKAGING; DNA REPLICATION; GENE DELETION; GENE LOCATION; GENETIC CONSERVATION; HERPES VIRUS; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; VIRUS CAPSID; VIRUS GENOME;

EID: 0031963626     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.1.48-56.1998     Document Type: Article

References (65)

1. Addison, C., F. J. Rixon, J. W. Palfreyman, M. O'Hara, and V. G. Preston. 1984. Characterisation of a herpes simplex virus type 1 mutant which has a temperature-sensitive defect in penetration of cells and assembly of capsids. Virology 138:246-259.
2. Addison, C., F. J. Rixon, and V. G. Preston. 1990. Herpes simplex virus type 1 UL28 gene product is important for the formation of mature capsids. J. Gen. Virol. 71:2377-2384.
3. Al-Kobaisi, M. F., F. J. Rixon, I. McDougall, and V. G. Preston. 1991. The herpes simplex virus UL33 gene product is required for the assembly of full capsids. Virology 180:380-388.
4. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1994. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
5. Baines, J. D., C. Cunningham, D. Nalwanga, and A. J. Davison. 1997. The UL15 gene of herpes simplex virus type 1 contains within its second exon a novel open reading frame that is translated in frame with the UL15 gene product. J. Virol. 71:2666-2673.
6. Baines, J. D., A. P. W. Poon, J. Rovnak, and B. Roizman. 1994. The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA. J. Virol. 68:8118-8124.
7. Barnett, J. W., D. A. Epstein, and H. W. Chan. 1983. Class I defective herpes simplex virus DNA as a molecular cloning vehicle in eucaryotic cells. J. Virol. 48:384-395.
8. Bataille, D., and A. Epstein. 1994. Herpes simplex virus replicative concatemers contain L components in inverted orientation. Virology 48:384-388.
9. Batterson, W., D. Furlong, and B. Roizman. 1983. Molecular genetics of herpes simplex virus. VIII. Further characterization of a temperature-sensitive mutant defective in release of viral DNA and in other stages of the viral reproductive cycle. J. Virol. 45:397-407.
10. Ben-Porat, T. 1983. Replication of herpesvirus DNA, p. 81-106. In B. Roizman (ed.). The herpesviruses. Plenum Press, New York, N.Y.
11. Chou, J., and B. Roizman. 1989. Characterization of DNA sequence-common and sequence-specific proteins binding to cis-acting sites for cleavage of the terminal a sequence of the herpes simplex virus 1 genome. J. Virol. 63:1059-1068.
12. Dalziel, R. G., and H. S. Marsden. 1984. Identification of two herpes simplex virus type 1-induced proteins (21k and 22k) which interact specifically with the a sequence of herpes simplex virus DNA. J. Gen. Virol. 65:1467-1475.
13. Davison, A. J. 1984. Structure of the genome termini of varicella-zoster virus. J. Gen. Virol. 65:1969-1977.
14. Deiss, L. P., J. Chou, and N. Frenkel. 1986. Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA. J. Virol. 59:605-618.
15. Deiss, L. P., and N. Frenkel. 1986. Herpes simplex virus amplicon: cleavage of concatemeric DNA is linked to packaging and involves amplification of the terminally reiterated a sequence. J. Virol. 57:933-941.
16. Ebling, A., G. M. Keil, E. Knust, and U. H. Koszinowski. 1983. Molecular cloning and physical mapping of murine cytomegalovirus DNA. J. Virol. 47:421-433.
17. Frenkel, N. 1981. Defective interfering herpesviruses, p. 91-120. In A. H. Hahmias, W. R. Dowdle, and R. S. Schinazy (ed.), The human herpesviruses - an interdisciplinary perspective. Elsevier Science Publishing, Inc., New York, N.Y.
18. Garber, D., S. Beverly, and D. Coen. 1993. Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis. Virology 197:459-462.
19. Hammerschmidt, W., H. Ludwig, and H. Buhk. 1988. Specificity of cleavage in replicative-form DNA of bovine herpesvirus 1. J. Virol. 62:1355-1363.
20. Hur, J., D. E. Nixon, and M. A. McVoy. Unpublished results.
21. Jacob, R. J., L. S. Morse, and B. Roizman. 1979. Anatomy of herpes simplex virus DNA. XII. Accumulation of head-to-tail concatemers in nuclei of infected cells and their role in the generation of four isomeric arrangements of viral DNA. J. Virol. 29:448-457.
22. Kemble, G. W., and E. S. Mocarski. 1989. A host cell protein binds to a highly conserved sequence element (pac-2) within the cytomegalovirus a sequence. J. Virol. 63:4715-4728.
23. Lamberti, C., and S. K. Weller. 1996. The herpes simplex virus type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion. Virology 226:403-407.
24. Marks, J. R., and D. H. Spector. 1984. Fusion of the termini of the murine cytomegalovirus genome after infection. J. Virol. 52:24-28.
25. Marks, J. R., and D. H. Spector. 1988. Replication of the murine cytomegalovirus genome: structure and role of the termini in generation and cleavage of concatenates. J. Virol. 162:98-107.
26. Martinez, R., R. Sarisky, P. Webber, and S. K. Weller. 1996. Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates. J. Virol. 70:2075-2085.
27. McVoy, M. A. and S. P. Adler. 1994. Human cytomegalovirus DNA replicates after early circularization and inversion occurs within the concatemer. J. Virol. 68:1040-1061.
28. McVoy, M. A., D. E. Nixon, and S. P. Adler. 1997. Cleavage and circularization of guinea pig cytomegalovirus genomes. J. Virol. 71:4209-4217.
29. Mercer, H. A., J. R. Marks, and D. H. Spector. 1983. Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith strain). Virology 129:94-106.
30. Mocarski, E. S., A. C. Liu, and R. R. Spaete. 1987. Structure and variability of the a sequence in the genome of human cytomegalovirus (Towne strain). J. Gen. Virol. 68:2223-2230.
31. Mocarski, E. S., L. E. Post, and B. Roizman. 1980. Molecular engineering of the herpes simplex virus genome: insertion of a second L-S junction into the genome causes additional genome inversions. Cell 22:243-255.
32. Mocarski, E. S., and B. Roizman. 1981. Site-specific inversion sequence of the herpes simplex virus genome: domain and structural features. Proc. Natl. Acad. Sci. USA 78:7047-7051.
33. Mocarski, E. S., and B. Roizman. 1982. Structure and role of the herpes simplex virus DNA termini in inversion, circularization, and generation of virion DNA. Cell 31:89-97.
34. Nasseri, M., and E. S. Mocarski. 1988. The cleavage recognition signal is contained within sequences surrounding an a-a junction in herpes simplex virus DNA. Virology 167:25-30.
35. Nixon, D. E., and M. A. McVoy. 1997. Unpublished data.
36. Patel, A. H., F. J. Rixon, C. Cunningham, and A. J. Davison. 1996. Isolation and characterization of herpes simplex virus type 1 mutants defective in the UL6 gene. Virology 217:111-123.
37. Poon, A. P. W., and B. Roizman. 1993. Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus type 1. J. Virol. 67:4497-4503.
38. Rawlinson, W. D., H. E. Farrell, and B. C. Barrell. 1996. Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 70:8833-8849.
39. Roizman, B., and A. E. Sears. 1993. The herpesviridae, a brief introduction, p. 1-9. In B. Roizman, R. J. Whitley, and C. Lopez (ed.), The human herpesviruses. Raven Press, New York, N.Y.
40. Roizman, B., and A. E. Sears. 1996. Herpes simplex viruses and their replication, p. 1048-1066. In B. N. Fields (ed.), Fundamental virology. Raven Press, New York, N.Y.
41. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
42. Secchiero, P., J. Nicholas, H. Deng, T. Xiaopeng, N. VanLoon, V. Ruvolo, Z. N. Berneman, M. S. Reitz, and S. Dewhurst. 1995. Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity. J. Virol. 69:8041-8045.
43. Severini, A., A. R. Morgan, D. R. Tovell, and D. L. J. Tyrrell. 1994. Study of the structure of replicative intermediates of HSV-1 DNA by pulsed-field gel electrophoresis. Virology 200:428-436.
44. Shafiqul, I. C., H. Buhk, H. Ludwig, and W. Hammerschmidt. 1990. Genomic termini of equine herpesvirus 1. J. Virol. 64:873-880.
45. Sherman, G., and S. Bachenheimer. 1987. DNA processing in temperature sensitive morphogenic mutants of HSV-1. Virology 158:427-430.
46. Sherman, G., and S. Bachenheimer. 1988. Characterization of intranuclear capsids made by ts morphogenic mutants of HSV-1. Virology 163:471-480.
47. Slobedman, B., and A. Simmons. 1997. Concatemeric intermediates of equine herpesvirus type 1 DNA replication contain frequent inversions of adjacent long segments of the viral genome. Virology 229:415-420.
48. Smiley, J. R., J. Duncan, and M. Howes. 1990. Sequence requirements for DNA rearrangements induced by the terminal repeat of herpes simplex virus 1 KOS DNA. J. Virol. 64:5036-5050.
49. Spaete, R. R., and N. Frenkel. 1982. The herpes simplex virus amplicon: a new eucaryotic defective-virus cloning-amplifying vector. Cell 30:295-304.
50. Stoddart, C. A., R. D. Cardin, J. M. Boname, W. C., Manning, G. B. Abenes, and E. S. Mocarski. 1994. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus. J. Virol. 68:6243-6253.
51. Stow, N., E. McMonagle, and A. J. Davison. 1983. Fragments from both termini of the herpes simplex virus type 1 genome contain signals required for the encapsidation of viral DNA. Nucleic Acids Res. 11:8205-8820.
52. Tamashiro, J. C., D. Filpula, R. Friedmann, and D. H. Spector. 1984. Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169. J. Virol. 52:541-548.
53. Tamashiro, J. C., and D. H. Spector. 1986. Terminal structure and heterogeneity in human cytomegalovirus strain AD169. J. Virol. 59:591-604.
54. Tengelsen, L. A., N. E. Pederson, P. R. Shaver, M. W. Wathen, and F. L. Homa. 1993. Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: isolation and characterization of two UL28 deletion mutants. J. Virol. 67:3470-3480.
55. Thomson, B. J., S. Dewhurst, and D. Gray. 1994. Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini. J. Virol. 68:3007-3014.
56. Umene, K. 1994. Excision of DNA fragments corresponding to the unit-length a sequence of herpes simplex virus type 1 and terminus variation predominate on one side of the excised fragment. J. Virol. 68:4377-4383.
57. Varmuza, S. L., and J. R. Smiley. 1985. Signals for site-specific cleavage of HSV-1 DNA maturation involves two separate cleavage events at sites distal to the recognition sequences. Cell 41:793-802.
58. Vieira, J., H. E. Farrell, W. D. Hawlinson, and E. S. Mocarski. 1994. Genes in the HindIII J fragment of the murine cytomegalovirus genome are dispensable for growth in cultured cells: insertion mutagenesis with the lacZ/gpt cassette. J. Virol. 68:4037-4046.
59. Vink, C., E. Beuken, and C. A. Bruggeman. 1996. Structure of the rat cytomegalovirus genome termini. J. Virol. 70:5221-5229.
60. Vlazny, D. A., A. Kwong, and N. Frenkel. 1982. Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA. Proc. Natl. Acad. Sci. USA 79: 1423-1427.
61. Weller, S. K., E. P. Carmichael, D. P. Aschman, D. J. Goldstein, and P. A. Schaffer. 1987. Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA. Virology 161:198-210.
62. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.
63. Yu, D., A. K. Sheaffer, D. J. Tenney, and S. K. Weller. 1997. Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins. J. Virol. 71:2656-2665.
64. Zhang, X., S. Efstathiou, and A. Simmons. 1994. Identification of novel herpes simplex virus replicative intermediates by field inversion gel electrophoresis: implications for viral DNA amplification strategies. Virology 202: 530-539.
65. Zimmermann, J., and W. Hammerschmidt. 1995. Structure and role of the terminal repeats of Epstein-Barr virus. J. Virol. 69:3147-3155.