Novel class of thiourea compounds that inhibit herpes simplex virus type 1 DNA cleavage and encapsidation: Resistance maps to the UL6 gene

Journal of Virology

Volumn 74, Issue 19, 2000, Pages 9054-9061

  Van Zeijl, M ^a   Fairhurst, J ^a   Jones, T R ^a   Vernon, S K ^a   Morin, J ^a   Larocque, J ^a   Feld, B ^a   O'Hara, B ^a   Bloom, J D ^a   Johann, S V ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUOROBENZAMIDE DERIVATIVE; CL 253824; N [4 [3 (CHLORO 2,4 DIMETHOXYPHENYL)THIOUREIDO]PHENYL]ACETAMIDE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; VIRUS DNA; WAY 150138;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CYTOMEGALOVIRUS; DNA CLEAVAGE; DNA PACKAGING; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; VARICELLA ZOSTER VIRUS; VIRUS CAPSID; VIRUS GENE; VIRUS GENOME; VIRUS INFECTION; VIRUS INHIBITION; VIRUS ISOLATION; VIRUS REPLICATION;

ANIMAL; CAPSID; CERCOPITHECUS AETHIOPS; DNA, VIRAL; DRUG RESISTANCE, MICROBIAL; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMAN; POINT MUTATION; THIOUREA; VERO CELLS; VIRUS REPLICATION;

EID: 0033804501     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.19.9054-9061.2000     Document Type: Article

References (48)

1. Herpes simplex virus type 1 UL28 gene product is important for the formation of mature capsids
2. The herpes simplex virus UL33 gene product is required for the assembly of full capsids
3. The herpes simplex virus UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA
4. New antivirals - Mechanism of action and resistance development
5. DNA packaging and cutting by phage terminases: Control in phage T4 by a synaptic mechanism
6. The gene product of human cytomegalovirus open reading frame UL56 binds the pac motif and has specific nuclease activity
7. Virus DNA packaging: The strategy used by phage λ
8. Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1
9. Survey of resistance of herpes simplex virus to acyclovir in northwest England
10. Acyclovir-resistant, pathogenic herpesviruses
11. Herpes simplex virus 1 helicase-primase: A complex of three herpes-encoded gene products
12. Channel catfish virus: A new type of herpesvirus
13. Biochemical aspects of the selective antiherpes activity of nucleoside analogues
14. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
15. Capsid assembly and DNA packaging in herpes simplex virus
16. Fine mapping of antigenic site II of herpes simplex virus glycoprotein D
17. Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential
18. Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins
19. Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames, UL89 and UL56
20. The herpes simplex virus type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion
21. The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments
22. The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA
23. A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function
24. The product of the UL6 gene of herpes simplex virus type 1 is associated with virus capsids
25. Isolation and characterization of herpes simplex virus type 1 mutants defective in the UL6 gene
26. Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1
27. Herpes simplex virus resistance to acyclovir: Clinical relevance
28. Prevalence of herpes simplex virus infection in patients suspected of genital herpes and virus typing by type specific fluorescent monoclonal antibodies
29. Characterization of the UL33 gene product of herpes simplex virus
30. The use of lead citrate at high pH as an electronopaque stain in electron microscopy
31. The family of herpesviridae
32. Herpes simplex viruses and their replication
33. Isolation of human cytomegalovirus DNA from infected cells
34. Stability of the cloned 'joint region' of herpes simplex virus DNA
35. The herpes simplex virus type 1 U(L)17 gene encodes virion tegument proteins that are required for cleavage and packaging of viral DNA
36. Herpes simplex virus DNA cleavage and packaging: Association of multiple forms of UL15-encoded proteins with B capsids requires at least the UL6, UL17, and UL28 genes
37. Identification and characterization of the bovine herpesvirus 1 UL7 gene and gene product, which are not essential for virus replication in cell culture
38. A comparison of PCR with virus isolation and direct antigen detection for diagnosis and typing of genital herpes
39. The herpes simplex virus 1 UL17 gene is required for localization of capsids and major and minor capsid proteins to intranuclear sites where viral DNA is cleaved and packaged
40. Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: Isolation and characterization of two UL28 deletion mutants
41. The UL8 component of the herpes simplex virus helicase-primase complex stimulates primer synthesis by a subassembly of the UL5 and UL52 components
42. Design, synthesis, and antiviral activity of certain 2,5,6-trihalo-1-(β-D-ribofuranosyl)benzimidazoles
43. Inhibition of human cytomegalovirus DNA maturation by a benzamidazole ribonucleoside is mediated through the UL89 gene product
44. The HSV-1 UL45 gene product is not required for growth in Veto cells
45. Genetic analysis of temperature-sensitive mutants of HSV-1: The combined use of complementation and physical mapping for cistron assignment
46. The epidemiology and clinical manifestations of herpes simplex virus infection
47. Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging