Helicobacter pylori-induced tyrosine phosphorylation of IKKβ contributes to NF-κB activation

Biological Chemistry

Volumn 392, Issue 4, 2011, Pages 387-393

  Rieke, Cornelia ^a   Papendieck, Anja ^a   Sokolova, Olga ^a   Naumann, Michael ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Epithelial cells; IkB ; Innate immune response; Lipid rafts; P65

Indexed keywords

I KAPPA B ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

ARTICLE; CONTROLLED STUDY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; LIPID RAFT; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION;

CELL LINE, TUMOR; HELICOBACTER PYLORI; HUMANS; I-KAPPA B KINASE; MEMBRANE MICRODOMAINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION; TYROSINE;

HELICOBACTER PYLORI;

EID: 79955420331     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2011.029     Document Type: Article

References (29)

1. Backert, S. and Naumann, M. (2010). What a disorder: Proinflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol. 18, 479-486.
2. Blake, R.A., Broome, M.A., Liu, X., Wu, J., Gishizky, M., Sun, L., and Courtneidge, S.A. (2000). SU6656, a selective Src family kinase inhibitor, used to probe growth factor signaling. Mol. Cell. Biol. 20, 9018-9027. (Pubitemid 32245931)
3. Brown, D.A. (2006). Lipid rafts, detergent-resistant membranes and raft targeting signals. Physiology (Bethesda) 21, 430-439. (Pubitemid 44879252)
4. Chang, Y.J., Wu, M.S., Lin, J.T., Sheu, B.S., Muta, T., Inoue, H., and Chen, C.C. (2004). Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kB activation. Mol. Pharmacol. 66, 1465-1477. (Pubitemid 39564773)
5. Crabtree, J.E. and Naumann, M. (2006). Epithelial cell signaling in Helicobacter pylori infection. Curr. Signal Transd. Ther. 1, 53-65.
6. Darwech, I., Otero, J.E., Alhawagri, M.A., and Abu-Amer, Y. (2010). Tyrosine phosphorylation is required for IkB kinase-b (IKKb) activation and function in osteoclastogenesis. J. Biol. Chem. 285, 25522-25530.
7. Dykstra, M., Cherukuri, A., Sohn, H.W., Tzeng, S.J., and Pierce, S.K. (2003). Location is everything: Lipid rafts and immune cell signaling. Annu. Rev. Immunol. 21, 457-481. (Pubitemid 37174538)
8. Foryst-Ludwig, A. and Naumann, M. (2000). p21-activated kinase 1 activates the nuclear factor kB (NF-kB)-inducing kinase-IkB kinases NF-kB pathway and proinflammatory cytokines in Helicobacter pylori infection. J. Biol. Chem. 275, 39779-39785. (Pubitemid 32059009)
9. Galbiati, F., Volonte, D., Goltz, J.S., Steele, Z., Sen, J., Jurcsak, J., Stein, D., Stevens, L., and Lisanti, M.P. (1998). Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster. Gene 210, 229-237. (Pubitemid 28171445)
10. Hanke, J.H., Gardner, J.P., Dow, R.L., Changelian, P.S., Brissette, W.H., Weringer, E.J., Pollok, B.A., and Connelly, P.A. (1996). Discovery of a novel, potent and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271, 695-701.
11. Huang, W.C., Chen, J.J., and Chen, C.C. (2003). c-Src-dependent tyrosine phosphorylation of IKKb is involved in tumor necrosis factor-a-induced intercellular adhesion molecule-1 expression. J. Biol. Chem. 278, 9944-9952.
12. Kamata, K., Manno, S., Ozaki, M., and Takakuwa, Y. (2008). Functional evidence for presence of lipid rafts in erythrocyte membranes: Gsa in rafts is essential for signal transduction. Am. J. Hematol. 83, 371-375. (Pubitemid 351614749)
13. Lahat, A., Ben-Horin, S., Horin, S.B., Lang, A., Fudim, E., Picard, O., and Chowers, Y. (2008). Lidocaine down-regulates nuclear factor-kB signalling and inhibits cytokine production and T cell proliferation. Clin. Exp. Immunol. 152, 320-327. (Pubitemid 351520916)
14. Lai, C.H., Chang, Y.C., Du, S.Y., Wang, H.J., Kuo, C.H., Fang, S.H., Fu, H.W., Lin, H.H., Chiang, A.S., and Wang, W.C. (2008). Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells. Infect. Immun. 76, 3293-3303.
15. Nakano, H., Shindo, M., Sakon, S., Nishinaka, S., Mihara, M., Yagita, H., and Okumura, K. (1998). Differential regulation of IkB kinase a and b by two upstream kinases, NF-kB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95, 3537-3542.
16. Naumann, M. (2005). Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells. Int. J. Med. Microbiol. 295, 335-341. (Pubitemid 41569401)
17. Neumann, M., Foryst-Ludwig, A., Klar, S., Schweitzer, K., and Naumann, M. (2006). The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-kB activation. Biol. Chem. 387, 79-86. (Pubitemid 43089597)
18. Pakkanen, K., Salonen, E., Mäkelä, A.R., Oker-Blom, C., Vattulainen, I., and Vuento, M. (2009). Desipramine induces disorder in cholesterol-rich membranes: Implications for viral trafficking. Phys. Biol. 6, 046004.
19. Perkins, N.D. (2006). Post-translational modifications regulating the activity and function of the nuclear factor kB pathway. Oncogene 25, 6717-6730. (Pubitemid 44657848)
20. Rieke, C., Kähne, T., Schweitzer, K., Schraven, B., Wienands, J., Engelke, M., and Naumann, M. (2010). Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells. Cell. Signal. 22, 395-403.
21. Scheidereit, C. (2006). IkB kinase complexes: Gateways to NF-kB activation and transcription. Oncogene 25, 6685-6705. (Pubitemid 44657846)
22. Schweitzer, K., Bozko, P.M., Dubiel, W., and Naumann, M. (2007). CSN controls NF-kB by deubiquitinylation of IkBa. EMBO J. 26, 1532-1541. (Pubitemid 46480929)
23. Schweitzer, K., Sokolova, O., Bozko, P.M., and Naumann, M. (2010). Helicobacter pylori induces NF-kB independent of CagA. EMBO Rep. 11, 10-11.
24. Sebald, A., Mattioli, I., and Schmitz, M.L. (2005). T cell receptorinduced lipid raft recruitment of the IkB kinase complex is necessary and sufficient for NF-kB activation occurring in the cytosol. Eur. J. Immunol. 35, 318-325. (Pubitemid 40123878)
25. Shambharkar, P.B., Blonska, M., Pappu, B.P., Li, H., You, Y., Sakurai, H., Darnay, B.G., Hara, H., Penninger, J., and Lin, X. (2007). Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 26, 1794-1805. (Pubitemid 46624041)
26. Su, T.T., Guo, B., Kawakami, Y., Sommer, K., Chae, K., Humphries, L.A., Kato, R.M., Kang, S., Patrone, L., Wall, R., et al. (2002). PKC-b controls IkB kinase lipid raft recruitment and activation in response to BCR signaling. Nat. Immunol. 3, 780-786.
27. van der Goot, F.G. and Harder, T. (2001). Raft membrane domains: From a liquid-ordered membrane phase to a site of pathogen attack. Semin. Immunol. 13, 89-97. (Pubitemid 32382330)
28. Wunder, C., Churin, Y., Winau, F., Warnecke, D., Vieth, M., Lindner, B., Zähringer, U., Mollenkopf, H.J., Heinz, E., and Meyer, T.F. (2006). Cholesterol glucosylation promotes immune evasion by Helicobacter pylori. Nat. Med. 12, 1030-1038. (Pubitemid 44353384)
29. Yang, F., Tang, E., Guan, K., and Wang, C.Y. (2003). IKKb plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J. Immunol. 170, 5630-5635. (Pubitemid 36617854)