Synthesis and structure-activity relationships of A novel class of dithiocarbamic acid esters as anticancer agent

Archiv der Pharmazie

Volumn 344, Issue 5, 2011, Pages 320-332

  Hou, Xueling ^a,c   Ge, Zemei ^a   Wang, Tingmin ^b   Guo, Wei ^a   Wu, Jun ^a   Cui, Jingrong ^a   Lai, Chingsan ^b   Li, Runtao ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Medinox Inc   (United States)

^c XINJIANG TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

Author keywords

Anticancer activity; Dithiocarbamic acid ester; SARs

Indexed keywords

2 PHENYL 3 OXO PIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 2,4,5 TRIMETHYLPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 2,5 DIMETHYLPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 2,6 DIOXOPIPERAZINE; 3 METHYLPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 3 OXO 4 METHYLPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 3 OXOPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 3,5 DIMETHYLPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 3,5 DIOXO PIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 3,5 DIOXOPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 4 METHYLHOMOPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 4 METHYLPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 4 METHYLPIPERIDINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; 4,4 DIOXOTHIOMORPHOLINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; ANTINEOPLASTIC AGENT; BRASSININ; CHROMONE DITHIOCARBAMATE; DITHIOCARBAMIC ACID DERIVATIVE; HOMOPIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; MORPHOLINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; N,N DIMETHYLETHYLENEDIAMINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; NITRILE; PIPERAZINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; PIPERIDINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; QUINAZOLINONE DITHIOCARBAMATE; RWJ 025856; SULFORAMATE; THALIDOMIDE DITHIOCARBAMATE; THIOMORPHOLINE 1 CARBODITHIOIC ACID 3 CYANO 3,3 DIPHENYLPROPYL ESTER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; CELL LINE; CELL STRAIN HL 60; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; WEIGHT REDUCTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HELA CELLS; HL-60 CELLS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES;

EID: 79955376081     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000259     Document Type: Article

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