New prodrug approach for amino acids and amino-acid-like drugs

European Journal of Medicinal Chemistry

Volumn 31, Issue 2, 1996, Pages 165-169

  Aboul Fadl, T ^a   El Shorbagi, A ^a  

^a Assiut University   (Egypt)

Author keywords

Amino acid; Drug delivery; First order hyrolysis; Glycine; Half life; Human serum; Lipophilicity; Primary amine; Prodrug; Tetrahydro 2H 1,3,5 thiadiazine 2 thione

Indexed keywords

AMINO ACID; AMINO ACID DERIVATIVE; PRODRUG; THIADIAZINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROLYSIS; LIPOPHILICITY; NUCLEAR MAGNETIC RESONANCE; PH; REACTION ANALYSIS;

EID: 0029998957     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)80450-8     Document Type: Article

References (18)

1. El-Shorbagi A (1994) Eur J Med Chem 29, 11-15
2. Steffansen B, Mork N, Bundgaard H (1989) Acta Pharm Nordica 2, 47-56
3. Bundgaard H, Nielsen NM (1987) J Med Chem 30, 451-454
4. Nielsen NM, Bundgaard H (1988) J Pharm Sci 77, 285-298
5. Bundgaard H, Nielsen NM (1988) Int J Pharm 43, 101-109
6. Nielsen NM, Bundgaard H (1989) J Med Chem 32, 727-734
7. Wermuth CG (1980) Chem Ind 433-436
8. Purdie JE, Benoiton NL (1973) J Chem Soc, Perkin Trans 11, 1845-1848
9. Silverman RB (1992) In: The Organic Chemistry of Drug Design and Drug Action, Academic Press, Inc, San Diego, CA, USA, chap 8
10. Biel JH, Abood LG (1971) In: Biogenic Amines and Physiological Membranes in Drug Therapy, Part B, Marcel Dekker Inc, NY, USA, 378-395
11. Thur Osol AR (1980) In: Remington's Pharmaceutical Sciences, 16th ed, Mack publishing Co, USA, chap 44
12. Testa B (1992) In: Advances in Drug Reseach, Vol 23 (Strolin Benedetti M, Dostert P, eds), Academic Press, London, UK, 67-106
13. Koskinen A (1993) In: Asymmetric Synthesis of Natural Products, John Wiley & Sons Ltd, Chichester, UK, 116-145
14. Kubinyi H (1979) In: Drug Res, Arzneimittel-forsching (Jucker E, ed), Vol 23, Birkhauser Verlag, Basel, Switzerland, 122-126
15. Tomlinson E (1975) J Chromatogr 113, 1-7
16. Hulshoff A, Perrin JH (1976) J Chromatogr 20, 65-80
17. Pagou M, Koutselinis A (1993) Chem Pharm Bull 41, 319-324
18. Moriguchi I, Hirono S, Liu Q, Nakagome I, Matsushita Y (1992) Chem Pharm Bull 40, 127-130