Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

Volumn 1304, Issue 1, 1996, Pages 11-20

  Nishimaki Mogami, Tomoko ^a   Suzuki, Kazuhiro ^a   Okochi, Eriko ^a   Takahashi, Atsushi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Bezafibrate; Clofibric acid; Inhibition; Phosphatidylethanolamine methylation; Phosphatidylethanolamine N methyltransferase; Rat hepatocyte

Indexed keywords

ANTILIPEMIC AGENT; BEZAFIBRATE; CLOFIBRIC ACID; COENZYME A; DITHIOTHREITOL; METHYLTRANSFERASE; N ETHYLMALEIMIDE; OLEIC ACID; PERFLUOROOCTANOIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; LIVER CELL; LIVER MICROSOME; METHYLATION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNTHESIS;

ANIMALS; BEZAFIBRATE; BUTYRIC ACIDS; CELLS, CULTURED; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; CLOFIBRIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; LIVER; METHYLATION; METHYLTRANSFERASES; MICROSOMES; NUCLEOTIDYLTRANSFERASES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; PHOSPHATIDYLETHANOLAMINES; RATS; RATS, WISTAR; SULFHYDRYL REAGENTS;

ANIMALIA;

EID: 0030580432     PISSN: 00052760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(96)00101-4     Document Type: Article

References (44)

1. [1] Sundler, R. and Åkesson, B. (1975) J. Biol. Chem. 250, 3359-3367.
2. [2] Vance, D.E. and Ridgway, N.D. (1988) Prog. Lipid Res. 27, 61-79.
3. [3] Cui, Z., Vance, J.E., Chen, M.H., Voelker, D.R. and Vance, D.E. (1993) J. Biol. Chem. 268, 16655-16663.
4. [4] Cui, Z., Houweling, M. and Vance, D.E. (1994) J. Biol. Chem. 269, 24531-24533.
5. [5] Chiang, P.K. and Cantoni, G.L. (1979) Biochem. Pharmacol. 28, 1897-1902.
6. [6] Pritchard, P.H., Chiang, P.K., Cantoni, G.L. and Vance, D.E. (1982) J. Biol. Chem. 257, 6362-6367.
7. [7] Vance, J.E., Nguyen, T.M. and Vance, D.E. (1986) Biochim. Biophys. Acta 875, 501-509.
8. [8] Vance, J.E. and Vance, D.E. (1986) FEBS Lett. 204, 243-246.
9. [9] Audubert, F., Pelech, S.L. and Vance, D.E. (1984) Biochim. Biophys. Acta 792, 348-357.
10. [10] Lock, E.A., Mitchell, A.M. and Elcombe, C.R. (1989) Annu. Rev. Pharmacol. Toxicol. 29, 145-163.
11. [11] Green, S. (1992) Biochem. Pharmacol. 43, 393-401.
12. [12] Issemann, I. and Green, S. (1990) Nature, 347, 645-650.
13. [13] Motojima, K. (1993) Cell Struct. Func. 18, 267-277.
14. [14] Yao, Z. and Vance, D.E. (1988) J. Biol. Chem. 263, 2998-3004.
15. [15] Ridgway, N.D. and Vance, D.E. (1987) J. Biol. Chem. 262, 17231-17239.
16. [16] Audubert, F. and Vance, D.E. (1983) J. Biol. Chem. 258, 10695-10701.
17. [17] Samborski, R.W. and Vance, D.E. (1993) Biochim. Biophys. Acta 1167, 15-21.
18. [18] Jamil, H., Utal, A.K. and Vance, D.E. (1992) J. Biol. Chem. 267, 1752-1760.
19. [19] Weinhold, P.A., Rounsifer, M.E. and Feldman, D.A. (1986) J. Biol. Chem. 261, 5104-5110.
20. [20] Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) J. Biol. Chem. 193, 265-275.
21. [21] Ridgway, N.D. and Vance, D.E. (1989) Biochim. Biophys. Acta 1004, 261-270.
22. [22] Ikeda, T., Aiba, K., Fukuda, K. and Tanaka, M. (1985) J. Biochem. 98, 475-482.
23. [23] Nishimaki-Mogami, T., Takahashi, A., Toyoda, K. and Hayashi, Y. (1993) Biochem. J. 295, 217-220.
24. [24] Pelech, S.L., Pritchard, P.H., Brindley, D.N. and Vance, D.E. (1983) J. Biol. Chem. 258, 6782-6788.
25. [25] Pelech, S.L. and Vance, D.E. (1984) Biochim. Biophys. Acta 779, 217-251.
26. [26] Cullis, P.R. and De Kruijff, B. (1978) Biochim. Biophys. Acta 513, 31-42.
27. [27] Ridgway, N.D. and Vance, D.E. (1988) J. Biol. Chem. 263, 16864-16871.
28. [28] Samborski, R.W., Ridgway, N.D. and Vance, D.E. (1990) J. Biol. Chem. 265, 18322-18329.
29. [29] Pelech, S.L., Pritchard, P.H., Brindley, D.N. and Vance, D.E. (1983) Biochem. J. 216, 129-136.
30. [30] Bronfman, M., Amigo, L. and Morales, M.N. (1986) Biochem. J. 239, 781-784.
31. [31] Kawashima, Y., Hirose, A. and Kozuka, H. (1984) Biochim. Biophys. Acta 795, 543-551.
32. [32] Reddy, J.K., Azarnoff, D.L. and Hignite, C. (1980) Nature, 283, 397-398.
33. [33] Kaikaus, R.M., Chan, W.K., Lysenko, N., Ray, R., Oritz de Montellano, P.R. and Bass, N.M. (1993) J. Biol. Chem. 268, 9593-9603.
34. [34] Alegret, M., Ferrando, R., Vázquez, M., Adzet, M., Merlos, M. and Laguna, J.C. (1994) Br. J. Pharmacol. 112, 551-556.
35. [35] Göttlicher, M., Widmark, E., Li, Q. and Gustafsson, J.-Å. (1992) Proc. Natl. Acad. Sci. USA 89, 4653-4657.
36. [36] Yu, K., Bayona, W., Kallen, C.B., Harding, H.P., Ravera, C.P., McMahon, G., Brown, M. and Lazar, M.A. (1995) J. Biol. Chem. 270, 23975-23983.
37. [37] Forman, B.M., Tontonoz, P., Chen, J., Brun, R.P., Spiegelman, B.M. and Evans, R.M. (1995) Cell, 83, 803-812.
38. [38] Kliewer, S.A., Lenhard, J.M., Willson, T.M., Patel, I., Morris, D.C. and Lehmann, J.M. (1995) Cell, 83, 813-819.
39. [39] Einarsson, K. and Angelin, B. (1986) Atheroscler. Rev. 15, 67-97.
40. [40] Vessby, B., Lithell, H., Hellsing, K., Ostlund-Lindqvist, A.M., Gustafsson, I.B., Boberg, J. and Ledermann, H. (1980) Atherosclerosis 37, 257-269.
41. [41] Schwandt, P. (1991) Eur. J. Clin. Pharmacol. 40, S41-S43.
42. [42] Kawashima, Y., Mizuguchi, H., Musoh, K. and Kozuka, H. (1994) Biochim. Biophys. Acta 1212, 311-318.
43. [43] Ståhlberg, D., Angelin, B. and Einarsson, K. (1989) J. Lipid Res. 30, 953-958.
44. [44] Parthasarathy, S., Kritchevsky, D. and Baumann, W.J. (1982) Proc. Natl. Acad. Sci. USA 79, 6890-6893.