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Volumn 11, Issue , 2011, Pages

Co-expression of AaPMT and AaTRI effectively enhances the yields of tropane alkaloids in Anisodus acutangulus hairy roots

Author keywords

[No Author keywords available]

Indexed keywords

ANISODAMINE; ANTICHOLINERGIC DRUGS; ANTIOXIDANT ACTIVITIES; BIOTECHNOLOGICAL APPROACHES; CO-EXPRESSION; EXPRESSION LEVELS; GENE TRANSCRIPTS; HAIRY ROOTS; IN-LINE; MARKET DEMAND; PERENNIAL PLANTS; RADICAL SCAVENGING; RATE LIMITING; TA CONTENT; TRANSGENIC HAIRY ROOTS; TRANSGENICS; TROPANE ALKALOIDS;

EID: 79955147749     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-11-43     Document Type: Article
Times cited : (45)

References (32)
  • 2
    • 11244313262 scopus 로고    scopus 로고
    • Induction of Tropane Alkaloid Formation in Transformed Root Cultures of Brugmansia suaveolens (Solanaceae)
    • Zayed R, Wink M. Induction of Tropane Alkaloid Formation in Transformed Root Cultures of Brugmansia suaveolens (Solanaceae). Z Naturforsch C 2004, 59(11-12):863-867.
    • (2004) Z Naturforsch C , vol.59 , Issue.11-12 , pp. 863-867
    • Zayed, R.1    Wink, M.2
  • 3
    • 58249097181 scopus 로고    scopus 로고
    • Molecular characterization and expression analysis of two distinct putrescine N-methyltransferases from roots of Anisodus acutangulus
    • 10.1111/j.1399-3054.2008.01178.x, 19055544
    • Kai GY, Zhang Y, Chen JF, Li L, Yan XM, Zhang R, Liao P, Lu X, Wang W, Zhou GY. Molecular characterization and expression analysis of two distinct putrescine N-methyltransferases from roots of Anisodus acutangulus. Physiologia Plantarum 2009, 135:121-129. 10.1111/j.1399-3054.2008.01178.x, 19055544.
    • (2009) Physiologia Plantarum , vol.135 , pp. 121-129
    • Kai, G.Y.1    Zhang, Y.2    Chen, J.F.3    Li, L.4    Yan, X.M.5    Zhang, R.6    Liao, P.7    Lu, X.8    Wang, W.9    Zhou, G.Y.10
  • 5
    • 79958100864 scopus 로고    scopus 로고
    • Protective effects of anisodine and anisodamine on acute lung injury induced by oleic acid in rats
    • Wang H, Zhang SH, Huang LS, Zhao RH, Wei HP. Protective effects of anisodine and anisodamine on acute lung injury induced by oleic acid in rats. Chinese Journal of Critical Care Medicine 1999, 19(11):663-664.
    • (1999) Chinese Journal of Critical Care Medicine , vol.19 , Issue.11 , pp. 663-664
    • Wang, H.1    Zhang, S.H.2    Huang, L.S.3    Zhao, R.H.4    Wei, H.P.5
  • 6
    • 29144527805 scopus 로고    scopus 로고
    • Protective Effects of Anisodine, Buscopan, Anisodamine on Acute Renal Failure with Dam-ages of Renal Microvessels in Rat
    • Wu GL, Zheng QY, Tian N. Protective Effects of Anisodine, Buscopan, Anisodamine on Acute Renal Failure with Dam-ages of Renal Microvessels in Rat. Chinese Journal of Microcirculation 2002, 12(1):6-8.
    • (2002) Chinese Journal of Microcirculation , vol.12 , Issue.1 , pp. 6-8
    • Wu, G.L.1    Zheng, Q.Y.2    Tian, N.3
  • 8
    • 39149144808 scopus 로고    scopus 로고
    • Ultrahigh diterpenoid tanshinone production through repeated osmotic stress and elicitor stimulation in fed-batch culture of Salvia miltiorrhiza hairy roots
    • 10.1007/s00253-007-1332-y, 18189134
    • Wu JY, Shi M. Ultrahigh diterpenoid tanshinone production through repeated osmotic stress and elicitor stimulation in fed-batch culture of Salvia miltiorrhiza hairy roots. Appl Microbiol Biotechnol 2008, 78:441-448. 10.1007/s00253-007-1332-y, 18189134.
    • (2008) Appl Microbiol Biotechnol , vol.78 , pp. 441-448
    • Wu, J.Y.1    Shi, M.2
  • 9
    • 0011206510 scopus 로고
    • Production of tropane alkaloids in cultured cells of Hyoscyamus niger
    • Yamada Y, Hashimoto T. Production of tropane alkaloids in cultured cells of Hyoscyamus niger. Plant Cell Rep 1982, 1:101-103.
    • (1982) Plant Cell Rep , vol.1 , pp. 101-103
    • Yamada, Y.1    Hashimoto, T.2
  • 10
    • 0001202642 scopus 로고
    • Spontaneousshoot organogenesis and plant regeneration from hairy root cultures of Hyoscyamus muticus
    • Oksman-Caldentey KM, Kivel O, Hiltunen R. Spontaneousshoot organogenesis and plant regeneration from hairy root cultures of Hyoscyamus muticus. Plant Sci 1991, 78:129-136.
    • (1991) Plant Sci , vol.78 , pp. 129-136
    • Oksman-Caldentey, K.M.1    Kivel, O.2    Hiltunen, R.3
  • 11
    • 0028870986 scopus 로고
    • Efficient plant regeneration from hairy root-derived protoplasts of Hyoscyamus muticus
    • Sevón N, Oksman-Caldentey KM, Hiltunen R. Efficient plant regeneration from hairy root-derived protoplasts of Hyoscyamus muticus. Plant Cell Rep 1995, 14:738-742.
    • (1995) Plant Cell Rep , vol.14 , pp. 738-742
    • Sevón, N.1    Oksman-Caldentey, K.M.2    Hiltunen, R.3
  • 12
    • 1842377477 scopus 로고    scopus 로고
    • Characterization of transgenic plants derived from hairy roots of Hyoscyamus muticus
    • Sevón N, Dräger B, Hiltunen R, Oksman-Caldentey KM. Characterization of transgenic plants derived from hairy roots of Hyoscyamus muticus. Plant Cell Rep 1997, 16:605-611.
    • (1997) Plant Cell Rep , vol.16 , pp. 605-611
    • Sevón, N.1    Dräger, B.2    Hiltunen, R.3    Oksman-Caldentey, K.M.4
  • 13
    • 35348897875 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a new cDNA encoding hyoscyamine 6β-hydroxylase from roots of Anisodus acutangulus
    • 10.5483/BMBRep.2007.40.5.715, 17927905
    • Kai GY, Chen JF, Li L, Zhou GY, Zhou LM, Zhang L, Chen YH, Zhao LX. Molecular cloning and characterization of a new cDNA encoding hyoscyamine 6β-hydroxylase from roots of Anisodus acutangulus. Journal of Biochemistry and Molecular Biology 2007, 40(5):715-722. 10.5483/BMBRep.2007.40.5.715, 17927905.
    • (2007) Journal of Biochemistry and Molecular Biology , vol.40 , Issue.5 , pp. 715-722
    • Kai, G.Y.1    Chen, J.F.2    Li, L.3    Zhou, G.Y.4    Zhou, L.M.5    Zhang, L.6    Chen, Y.H.7    Zhao, L.X.8
  • 14
    • 0027078552 scopus 로고
    • Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition
    • 10.1073/pnas.89.24.11799, 50644, 1465402
    • Yun DJ, Hashimoto T, Yamada Y. Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition. Proc Natl Acad Sci USA 1992, 89:11799-11803. 10.1073/pnas.89.24.11799, 50644, 1465402.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11799-11803
    • Yun, D.J.1    Hashimoto, T.2    Yamada, Y.3
  • 15
    • 65349184006 scopus 로고    scopus 로고
    • Opportunities in metabolic engineering to facilitate scalable alkaloid production
    • 10.1038/nchembio.160, 19377455
    • Leonard E, Runguphan W, O'Connor S, Prather KJ. Opportunities in metabolic engineering to facilitate scalable alkaloid production. Nat Chem Biol 2009, 5(5):292-300. 10.1038/nchembio.160, 19377455.
    • (2009) Nat Chem Biol , vol.5 , Issue.5 , pp. 292-300
    • Leonard, E.1    Runguphan, W.2    O'Connor, S.3    Prather, K.J.4
  • 16
    • 56849092949 scopus 로고
    • Chemical analysis of Anisodus acutangulus in Yunnan and extraction of atropine sulphate
    • Wu DK, Wang FL, Chen ZR, Yang JS, Huang QL. Chemical analysis of Anisodus acutangulus in Yunnan and extraction of atropine sulphate. Med Pharm Yunnan 1962, 3:67-68.
    • (1962) Med Pharm Yunnan , vol.3 , pp. 67-68
    • Wu, D.K.1    Wang, F.L.2    Chen, Z.R.3    Yang, J.S.4    Huang, Q.L.5
  • 17
    • 0032215657 scopus 로고    scopus 로고
    • Expression of two consecutive genes of a secondary metabolic pathway in transgenic tobacco: molecular diversity influences levels of expression and product accumulation
    • 10.1023/A:1006000229229, 9862494
    • Leech MJ, May K, Hallard D, Verpoorte R, Luca VD, Christou P. Expression of two consecutive genes of a secondary metabolic pathway in transgenic tobacco: molecular diversity influences levels of expression and product accumulation. Plant Mol Biol 1998, 38:765-774. 10.1023/A:1006000229229, 9862494.
    • (1998) Plant Mol Biol , vol.38 , pp. 765-774
    • Leech, M.J.1    May, K.2    Hallard, D.3    Verpoorte, R.4    Luca, V.D.5    Christou, P.6
  • 19
    • 73949092455 scopus 로고    scopus 로고
    • Molecular cloning, characterization of two tropinone reductases in Anisodus acutangulus and enhancement of tropane alkaloids production in AaTRI-transformed hairy roots
    • 10.1042/BA20090171, 19751215
    • Kai GY, Li L, Wang J, Zhang Y, Zhang R, Yan XM, Liao P, Lu X, Wang W, Lu Y, Zhou GY. Molecular cloning, characterization of two tropinone reductases in Anisodus acutangulus and enhancement of tropane alkaloids production in AaTRI-transformed hairy roots. Biotechnol Appl Biochem 2009, 54(3):177-186. 10.1042/BA20090171, 19751215.
    • (2009) Biotechnol Appl Biochem , vol.54 , Issue.3 , pp. 177-186
    • Kai, G.Y.1    Li, L.2    Wang, J.3    Zhang, Y.4    Zhang, R.5    Yan, X.M.6    Liao, P.7    Lu, X.8    Wang, W.9    Lu, Y.10    Zhou, G.Y.11
  • 20
    • 0032814989 scopus 로고    scopus 로고
    • Enhancement of scopolamine production in Hyscyamus muticus L. hairy root cultures by genetic engineering
    • Jouhikainen K, Lindgren L, Jokelainen T, Hiltunen R, Teeri TH, Oksmn-Caldentey K-M. Enhancement of scopolamine production in Hyscyamus muticus L. hairy root cultures by genetic engineering. Planta 1999, 208:545-551.
    • (1999) Planta , vol.208 , pp. 545-551
    • Jouhikainen, K.1    Lindgren, L.2    Jokelainen, T.3    Hiltunen, R.4    Teeri, T.H.5    Oksmn-Caldentey, K.-M.6
  • 21
    • 0037300536 scopus 로고    scopus 로고
    • Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus
    • 10.1093/jxb/54.381.203, 12493848
    • Moyano E, Jouhikainen K, Tammela P, Palazón J, Cusidó RM, Piñol MT, Teeri TH, Oksman-Caldentey KM. Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus. J Exp Bot 2003, 54(381):203-211. 10.1093/jxb/54.381.203, 12493848.
    • (2003) J Exp Bot , vol.54 , Issue.381 , pp. 203-211
    • Moyano, E.1    Jouhikainen, K.2    Tammela, P.3    Palazón, J.4    Cusidó, R.M.5    Piñol, M.T.6    Teeri, T.H.7    Oksman-Caldentey, K.M.8
  • 23
    • 0037041051 scopus 로고    scopus 로고
    • Alkaloid production in Duboisia hybrid hairy root cultures overexpressing the pmt gene
    • 10.1016/S0031-9422(02)00044-4, 11909625
    • Moyano E, Fornalé S, Palazón J, Cusidó RM, Bagni N, Piñol MT. Alkaloid production in Duboisia hybrid hairy root cultures overexpressing the pmt gene. Phytochemistry 2002, 59:697-702. 10.1016/S0031-9422(02)00044-4, 11909625.
    • (2002) Phytochemistry , vol.59 , pp. 697-702
    • Moyano, E.1    Fornalé, S.2    Palazón, J.3    Cusidó, R.M.4    Bagni, N.5    Piñol, M.T.6
  • 24
    • 79955136372 scopus 로고    scopus 로고
    • The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots
    • Peebles CA, Sander GW, Hughes EH, Peacock R, Shanks JV, San KY. The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metab Eng 2010,
    • (2010) Metab Eng
    • Peebles, C.A.1    Sander, G.W.2    Hughes, E.H.3    Peacock, R.4    Shanks, J.V.5    San, K.Y.6
  • 25
    • 14544305686 scopus 로고    scopus 로고
    • Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures
    • 10.1093/jxb/eri067, 15642710
    • Richter U, Rothe G, Fabian AK, Rahfeld B, Dräger B. Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures. J Exp Bot 2005, 56(412):645-52. 10.1093/jxb/eri067, 15642710.
    • (2005) J Exp Bot , vol.56 , Issue.412 , pp. 645-652
    • Richter, U.1    Rothe, G.2    Fabian, A.K.3    Rahfeld, B.4    Dräger, B.5
  • 26
    • 61849117436 scopus 로고    scopus 로고
    • A New Class of Natural Glycopeptides with Sugar Moietydependent antioxidant activities derived from Ganoderma lucidum fruiting bodies
    • 10.1021/pr800554w, 2656399, 18989955
    • Wu YL, Wang DN. A New Class of Natural Glycopeptides with Sugar Moietydependent antioxidant activities derived from Ganoderma lucidum fruiting bodies. J Proteome Res 2009, 8(2):436-442. 10.1021/pr800554w, 2656399, 18989955.
    • (2009) J Proteome Res , vol.8 , Issue.2 , pp. 436-442
    • Wu, Y.L.1    Wang, D.N.2
  • 27
    • 79958084579 scopus 로고    scopus 로고
    • Comparison of Photosynthetic Pigment Contents and Antioxidase Activity of Anisodus tanguticus from Different Leaf Layers Grown at Two Altitudes Level in Qinghai-Tibet Plateau
    • Zhang B, Shi SB, Li HP, Han F. Comparison of Photosynthetic Pigment Contents and Antioxidase Activity of Anisodus tanguticus from Different Leaf Layers Grown at Two Altitudes Level in Qinghai-Tibet Plateau. Acta Bot Boreal-Occident Sin Chinese Journal 2008, 28(9):1778-1786.
    • (2008) Acta Bot Boreal-Occident Sin Chinese Journal , vol.28 , Issue.9 , pp. 1778-1786
    • Zhang, B.1    Shi, S.B.2    Li, H.P.3    Han, F.4
  • 28
    • 56849115679 scopus 로고    scopus 로고
    • Optimization of Induction and Culture Conditions and Tropane Alkaloid Production in Hairy Roots of Anisodus acutangulus
    • Li L, Wang J, Wang W, Lu Y, Wang YL, Zhou GY, Kai GY. Optimization of Induction and Culture Conditions and Tropane Alkaloid Production in Hairy Roots of Anisodus acutangulus. Biotechnol Bioproc E 2008, 13:606-612.
    • (2008) Biotechnol Bioproc E , vol.13 , pp. 606-612
    • Li, L.1    Wang, J.2    Wang, W.3    Lu, Y.4    Wang, Y.L.5    Zhou, G.Y.6    Kai, G.Y.7
  • 29
    • 58149156291 scopus 로고    scopus 로고
    • Effects of Elicitors on Tropane Alkaloids and Gene Expression in Atropa baetica Transgenic Hairy Roots
    • 10.1021/np800573j, 19053510
    • EL Jaber-Vazdekis N, Barres ML, Ravelo AG, Zarate R. Effects of Elicitors on Tropane Alkaloids and Gene Expression in Atropa baetica Transgenic Hairy Roots. J Nat Prod 2008, 71(12):2026-2031. 10.1021/np800573j, 19053510.
    • (2008) J Nat Prod , vol.71 , Issue.12 , pp. 2026-2031
    • EL Jaber-Vazdekis, N.1    Barres, M.L.2    Ravelo, A.G.3    Zarate, R.4
  • 30
    • 64949150525 scopus 로고    scopus 로고
    • Molecular cloning, characterization and expression analysis of a new gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Salvia miltiorrhiza
    • Liao P, Zhou W, Zhang L, Wang J, Yan XM, Zhang Y, Zhang R, Li L, Zhou GY, Kai GY. Molecular cloning, characterization and expression analysis of a new gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Salvia miltiorrhiza. Acta Physiol Plant 2009, 31:565-572.
    • (2009) Acta Physiol Plant , vol.31 , pp. 565-572
    • Liao, P.1    Zhou, W.2    Zhang, L.3    Wang, J.4    Yan, X.M.5    Zhang, Y.6    Zhang, R.7    Li, L.8    Zhou, G.Y.9    Kai, G.Y.10
  • 31
    • 77953555679 scopus 로고    scopus 로고
    • Characterization, Expression Profiling, and Functional Identification of a Gene Encoding Geranylgeranyl Diphosphate Synthase from Salvia miltiorrhiza
    • Kai GY, Liao P, Zhang T, Zhou W, Wang J, Xu H, Liu YY, Zhang L. Characterization, Expression Profiling, and Functional Identification of a Gene Encoding Geranylgeranyl Diphosphate Synthase from Salvia miltiorrhiza. Biotechnol Bioproc E 2010, 15:236-245.
    • (2010) Biotechnol Bioproc E , vol.15 , pp. 236-245
    • Kai, G.Y.1    Liao, P.2    Zhang, T.3    Zhou, W.4    Wang, J.5    Xu, H.6    Liu, Y.Y.7    Zhang, L.8
  • 32
    • 53249125530 scopus 로고    scopus 로고
    • Antibacterial and antioxidant properties of the methanol extracts of the leaves and stems of Calpurnia aurea
    • Adedapo AA, Jimoh FO, Koduru S, Afolayan AJ, Masika PJ. Antibacterial and antioxidant properties of the methanol extracts of the leaves and stems of Calpurnia aurea. BMC Complem Alt Med 2008, 8:53.
    • (2008) BMC Complem Alt Med , vol.8 , pp. 53
    • Adedapo, A.A.1    Jimoh, F.O.2    Koduru, S.3    Afolayan, A.J.4    Masika, P.J.5


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