Ultrahigh diterpenoid tanshinone production through repeated osmotic stress and elicitor stimulation in fed-batch culture of Salvia miltiorrhiza hairy roots

Applied Microbiology and Biotechnology

Volumn 78, Issue 3, 2008, Pages 441-448

  Wu, Jian Yong ^a   Shi, Ming ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Fed batch culture; Hairy root; Osmotic stress; Salvia miltiorrhiza; Tanshinones; Yeast elicitor

Indexed keywords

ALCOHOLS; BATCH CELL CULTURE; NUTRIENTS; OSMOSIS; POLYSACCHARIDES; STRESS ANALYSIS;

FED-BATCH CULTURE; HAIRY ROOT; SALVIA MILTIORRHIZA; SORBITOL; YEAST ELICITOR;

PLANT CELL CULTURE;

DITERPENOID; SORBITOL; TANSHINONE;

ANGIOSPERM; ENVIRONMENTAL STRESS; OSMOSIS; PLANT EXTRACT; ROOT; SYNERGISM; TERPENE; YEAST;

ARTICLE; CONTROLLED STUDY; DRY WEIGHT; FED BATCH CULTURE; NONHUMAN; OSMOTIC STRESS; PLANT GROWTH; PLANT ROOT; SALVIA MILTIORRHIZA;

BIOMASS; BIOREACTORS; CULTURE MEDIA; DITERPENES; OSMOTIC PRESSURE; PHENANTHRENES; PLANT ROOTS; PLANTS, MEDICINAL; POLYSACCHARIDES, BACTERIAL; SALVIA MILTIORRHIZA; TISSUE CULTURE TECHNIQUES;

SALVIA MILTIORRHIZA;

EID: 39149144808     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-007-1332-y     Document Type: Article

References (28)

1. Bozhkov PV, von Arnold S (1998) Polyethylene glycol promotes maturation but inhibits further development of Picea abies somatic embryos. Physiol Plant 104:211-224
2. Chen Z (1991) Danshen. In: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences (eds) Cultivation of Chinese medicinal plants (in Chinese). Agricultural, Beijing, pp 455-461
3. Chen L, Zhu J (2004) Determination of four fat-soluble ingredients in Radix Salviae miltiorrhizae. Zhongguo Yao Shi (in Chinese) 18:749-751
4. Chen H, Chen F, Zhang YL, Song JY (1999) Production of lithospermic acid B and rosmarinic acid in hairy root cultures of Salvia miltiorrhiza. J Ind Microbiol Biotechnol 22:133-138
5. Do CB, Cormier F (1990) Accumulation of anthocyanins enhanced by a high osmotic potential in grape (Vitis vinifera L.) cell suspensions. Plant Cell Rep 9:143-146
6. Dombrowski JE (2003) Salt stress activation of wound-related genes in tomato plants. Plant Physiol 132:2098-2107
7. Fujita M, Fujita Y, Noutoshi Y, Takahashi F, Narusaka Y, Yamaguchi-Shinozaki K, Shinozaki K (2006) Crosstalk between abiotic and biotic stress responses: a current view from the points of convergence in the stress signalling networks. Curr Opin Plant Biol 9:436-442
8. Furze JM, Rhodes MJC, Parr AJ, Robins RJ, Withehead IM, Threlfall DR (1991) Abiotic factors elicit sesquiterpenoid phytoalexin production but not alkaloid production in transformed root cultures of Datura stramonium. Plant Cell Rep 10:111-114
9. Giri A, Narasu L (2000) Transformed hairy roots: recent trends and applications. Biotechnol Adv 18:1-22
10. Guillon S, Trémouillaux-Guiller J, Pati PK, Rideau M, Gantet P (2006) Hairy root research: recent scenario and exciting prospects. Curr Opin Plant Biol 9:341-346
11. Hu ZB, Alfermann AW (1993) Diterpenoid production in hairy root cultures of Salvia miltiorrhiza. Phytochemistry 32:699-703
12. Kim SI, Choi HK, Kim JH, Lee HS, Hong SS (2001) Effect of osmotic pressure on paclitaxel production in suspension cell cultures of Taxus chinensis. Enzyme Microb Technol 28:202-209
13. Kim Y, Wyslouzil B, Weathers P (2002) Secondary metabolism of hairy root cultures in bioreactors. In Vitro Cell Dev Biol Plant 38:1-10
14. Linden JC, Phisalaphong M (2000) Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis. Plant Sci 158:41-51
15. Pitta-Alvarez SI, Spollansky TC, Giulietti AM (2000) The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida. Enzyme Microb Technol 26:252-258
16. Qian ZG, Zhao ZJ, Xu YF, Qian XH, Zhong JJ (2005) Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed-batch cultivation of Taxus chinensis cells. Biotechnol Bioeng 90:516-521
17. Ramakrishnan D, Curtis WR (2004) Trickle-bed root culture bioreactor design and scale-up: growth, fluid dynamics, and oxygen mass transfer. Biotechnol Bioeng 88:248-260
18. Shi M, Kwok KW, Wu JY (2007) Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by hyperosmotic stress and yeast elicitor. Biotechnol Appl Biochem 46:191-196
19. Singh G, Gavrieli J, Oakey JS, Curtis WR (1998) Interaction of methyl jasmonate, wounding and fungal elicitation during sesquiterpene induction in Hyoscyamus muticus in root cultures. Plant Cell Rep 17:391-395
20. Tang W, Eisenbrand G (1992) Chinese drugs of plant origin: chemistry, pharmacology, and use in traditional and modern medicine. Springer, Berlin, pp 891-902
21. Wu JY, Wong K, Ho KP, Zhou LG (2005) Enhancement of saponin production in Panax ginseng cell culture by osmotic stress and nutrient feeding. Enzyme Microb Technol 36:133-138
22. Yan Q, Hu Z, Tan RX, Wu J (2005) Efficient production and recovery of diterpenoid tanshinones in Salvia miltiorrhiza hairy root cultures with in situ adsorption, elicitation and semi-continous operation. J Biotechnol 119:416-424
23. Zhang C, Yan Q, Cheuk WK Wu J (2004) Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag elicitation and nutrient feeding. Planta Med 70:147-151
24. Zhao J, Hu Q, Zhu WH (2001) Enhanced catharanthine production in Catharanthus roseus cell cultures by combined elicitor treatment in shake flasks and bioreactors. Enzyme Microb Technol 28:673-681
25. Zhao J, Davis LCT, Verpoorte R (2005) Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol Adv 23:283-333
26. Zhao J, Matsunaga Y, Fujita K, Sakai K (2006) Signal transduction and metabolic flux of beta-thujaplicin and monoterpene biosynthesis in elicited Cupressus lusitanica cell cultures. Met Eng 8:14-29
27. Zhong JJ, Yue CJ (2005) Plant cells: secondary metabolite heterogeneity and its manipulation. Adv Biochem Eng Biotechnol 100:53-88
28. Zhou LG, Wu JY (2006) Development and application of medicinal plant tissue cultures for production of drugs and herbal medicinals in China. Nat Prod Rep 23:789-810