Anisodamine production from natural sources: Seedlings and hairy root cultures of Argentinean and Colombian Brugmansia Candida plants

Planta Medica

Volumn 76, Issue 4, 2010, Pages 402-405

  Cardillo, Alejandra Beatriz ^a   Maria Otalvaro Alvarez, Ángela ^b   Calabró Lopez, Ariel ^a   Enrique Velásquez Lozano, Mario ^b   Rodríguez Talou, Julián ^a   Maria Giulietti, Ana ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

Anisodamine; Brugmansia candida; Hairy root cultures; Scopolamine; Solanaceae

Indexed keywords

ANISODAMINE; HYOSCYAMINE; OXYGENASE; SCOPOLAMINE;

ANGIOSPERM; ARGENTINA; ARTICLE; COLOMBIA; DATURA; DRUG SYNTHESIS; DRY WEIGHT; ENZYME ACTIVITY; GERMINATION; HAIRY ROOT CULTURE; IN VITRO STUDY; NONHUMAN; PLANT LEAF; SEEDLING;

COLOMBIA; PLANT EXTRACTS; PLANT ROOTS; SEEDLING; SOLANACEAE; SOLANACEOUS ALKALOIDS;

BRUGMANSIA CANDIDA; SOLANACEAE;

EID: 77749233765     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1186164     Document Type: Article

References (30)

1. Roses O E., Miño J, Villamil E C. Acción farmacodinámica de las flores de Brugmansia candida. Fitoterapia 1988 59 120-127
2. Giulietti A M., Parr A J., Rhodes M J. Tropane alkaloid production in transformed root cultures of Brugmansia candida. Planta Med 1993 59 428-431
3. Palazón J, Moyano E, Cusidó R M., Bonfill M, Oksman-Caldentey K-M, Pinol M T. Alkaloid production in Duboisia hybrid hairy roots and plants overexpressing the h6h gene. Plant Sci 2003 165 1289-1295
4. Hashimoto T, Yamada Y. Hyoscyamine 6beta-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, in alkaloid-producing root cultures. Plant Physiol 1986 81 619-625
5. Zhang L, Ding R, Chai Y, Bonfill M, Moyano E, Oksman-Caldentey K M., Xu T, Pi Y, Wang Z, Zhang H, Kai G, Liao Z, Sun X, Tang K. Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures. Proc Natl Acad Sci USA 2004 101 6786-6791
6. Poupko J M., Baskin S I., Moore E. The pharmacological properties of anisodamine. J Appl Toxicol 2006 27 116-121
7. Wang T N., Yang H J., Gu-Ling L, Li J Y., Zheng X X. Advanced measurement and quantitative appraise of anisodamine on calcium triggered in cardiac myocyte. Engineering in Medicine and Biology 27th Annual Conference, Shanghai, China; 2005.
8. Wang P Y., Chen J W., Hwang F. Anisodamine causes acyl chain interdigitation in phosphatidylglycerol. FEBS Lett 1993 332 193-196
9. Wang H, Lu Y, Chen H Z. Differentiating effects of anisodamine on cognitive amelioration and peripheral muscarinic side effects induced by pilocarpine in mice. Neurosci Lett 2003 344 173-176
10. Sheng C Y., Gao W Y., Guo Z R., He L X. Anisodamine restores bowel circulation in burn shock. Burns 1997 23 142-146
11. Norby F L., Ren J. Anisodamine inhibits cardiac contraction and intracellular Ca(2+) transients in isolated adult rat ventricular myocytes. Eur J Pharmacol 2002 439 21-25
12. Wu Y F., L W, Lu Q, Zhang W S. Asymmetric synthesis of anisodine. Chin Chem Lett 2005 16 1287-1289
13. Yang L M., Xie Y F., Chen H Z., Lu Y. Diastereomeric and enantiomeric high-performance liquid chromatographic separation of synthetic anisodamine. J Pharm Biomed Anal 2007 43 905-909
14. Lee K T., Yamakawa T, Kodama T, Shimomura K. Effects of chemicals on alkaloid production by transformed roots of Belladonna. Phytochemistry 1998 49 2343-2347
15. Li J, Chun Y, Jua H. Simultaneous electrochemiluminiscence detection of anisodamine, atropine and scopolamine in Flos daturae by capillary electrophoresis using b-cyclodextrin as additive. Electroanalysis 2007 19 1569-1574
16. Diwan R, Malpathak N. Novel technique for scaling up of micropropagated Ruta graveolens shoots using liquid culture systems: a step towards commercialization. New Biotechnol 2008 25 85-91
17. Liu C. Novel plant reactors for pharmaceutical production. World Congress on In Vitro Biology, Arkansas State University. 2008
18. Guillon S, Tremouillaux-Guiller J, Pati P K., Rideau M, Gantet P. Hairy root research: recent scenario and exciting prospects. Curr Opin Plant Biol 2006 9 341-346
19. Hashimoto T, Hayashi A, Amano Y, Kohno J, Iwanari H, Usuda S, Yamada Y. Hyoscyamine 6beta-hydroxylase, an enzyme involved in tropane alkaloid biosynthesis, is localized at the pericycle of the root. J Biol Chem 1991 266 4648-4653
20. Zarate R, el Jaber-Vazdekis N, Medina B, Ravelo A G. Tailoring tropane alkaloid accumulation in transgenic hairy roots of Atropa baetica by over-expressing the gene encoding hyoscyamine 6beta-hydroxylase. Biotechnol Lett 2006 28 1271-1277
21. Hamill J D., Parr A J., Rhodes M J. C., Robins R J., Walton N J. New routes to plant secondary products. Biotechnology 1987 5 800-804
22. Cardillo A B., Giulietti A M., Marconi P L. Analysis and sequencing of h6hmRNA, last enzyme in the tropane alkaloids pathway from anthers and hairy root cultures of Brugmansia candida (Solanaceae). Electronic J Biotechnol 2006 9 195-198
23. Cardillo A B., Rodriguez Talou J, Giulietti A M. Expression of Brugmansia candida hyoscyamine 6beta-hydroxylase gene in Saccharomyces cerevisiae and its potential use as biocatalyst. Microb Cell Fact 2008 7 17
24. Kursinszki L, Hank H, Laszlo I, Szoke E. Simultaneous analysis of hyoscyamine, scopolamine, 6beta-hydroxyhyoscyamine and apoatropine in Solanaceous hairy roots by reversed-phase high-performance liquid chromatography. J Chromatogr A 2005 1091 32-39
25. Cheng K D., Zhu W H., Li X L., Meng C, Sun Z M., Yang D H. Biotransformation of hyoscyamine by suspension cultures of Anisodus tanguticus. Planta Med 1987 53 211-213
26. Zhang H M., Ou Z L., Yamamoto T. Anisodamine inhibits shiga toxin type 2-mediated tumor necrosis factor-alpha production in vitro and in vivo. Exp Biol Med (Maywood) 2001 226 597-604
27. Pitta-Alvarez S I., Spollansky T C., Giulietti A M. The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida. Enzyme Microb Technol 2000 26 252-258
28. Gamborg O L., Miller R A., Ojima K. Nutrient requirements of suspension cultures of soybean root cells. Exp Cell Res 1968 50 151-158
29. Hamill J D., Rounsley S, Spencer A, Todd G, Rhodes J C. The use of the polymerase chain reaction in plant transformation studies. Plant Cell Rep 1991 10 221-224
30. Payne J, Hamill J D., Robins R J., Rhodes M J. Production of hyoscyamine by Hairy Root cultures of Datura stramonium. Planta Med 1987 53 474-478