메뉴 건너뛰기




Volumn 10, Issue 4, 2011, Pages 487-498

IFN-α as a vaccine adjuvant: Recent insights into the mechanisms and perspectives for its clinical use

Author keywords

adjuvant; cancer; dendritic cell; immunity; infectious diseases; interferon; vaccine

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; BETA INTERFERON; CANCER VACCINE; HEPATITIS B VACCINE; IMIQUIMOD; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; INTERFERON; PLACEBO; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RESIQUIMOD;

EID: 79955081753     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/erv.11.9     Document Type: Review
Times cited : (32)

References (86)
  • 1
    • 33748470359 scopus 로고    scopus 로고
    • Fifty Years of Interferon Research: Aiming at a Moving Target
    • DOI 10.1016/j.immuni.2006.08.008, PII S1074761306003931
    • Vilcek J. Fifty years of interferon research: aiming at a moving target. Immunity 25(3), 343-348 (2006). (Pubitemid 44354219)
    • (2006) Immunity , vol.25 , Issue.3 , pp. 343-348
    • Vilcek, J.1
  • 2
    • 0030221837 scopus 로고    scopus 로고
    • The neglected role of type I interferon in the T-cell response: Implications for its clinical use
    • DOI 10.1016/0167-5699(96)10028-1
    • Belardelli F, Gresser I. The neglected role of type I interferon in the T cell response: implications for its clinical use. Immunol. Today 17(8), 369-372 (1996). (Pubitemid 26247796)
    • (1996) Immunology Today , vol.17 , Issue.8 , pp. 369-372
    • Belardelli, F.1    Gresser, I.2
  • 3
    • 0036533489 scopus 로고    scopus 로고
    • Cytokines as a link between innate and adaptive antitumor immunity
    • DOI 10.1016/S1471-4906(02)02195-6, PII S1471490602021956
    • Belardelli F, Ferrantini M. Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol. 23(4), 201-208 (2002). (Pubitemid 34260936)
    • (2002) Trends in Immunology , vol.23 , Issue.4 , pp. 201-208
    • Belardelli, F.1    Ferrantini, M.2
  • 4
    • 0034658658 scopus 로고    scopus 로고
    • Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice
    • DOI 10.1084/jem.191.10.1777
    • Santini SM, Lapenta C, Logozzi M et al. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J. Exp. Med. 191(10), 1777-1788 (2000). (Pubitemid 30331574)
    • (2000) Journal of Experimental Medicine , vol.191 , Issue.10 , pp. 1777-1788
    • Santini, S.M.1    Lapenta, C.2    Logozzi, M.3    Parlato, S.4    Spada, M.5    Di Pucchio, T.6    Belardelli, F.7
  • 5
    • 77951491478 scopus 로고    scopus 로고
    • Recent advances on the immunomodulatory effects of IFN-α: Implications for cancer immunotherapy and autoimmunity
    • Rizza P, Moretti F, Belardelli F. Recent advances on the immunomodulatory effects of IFN-α: implications for cancer immunotherapy and autoimmunity. Autoimmunity 43(3), 204-209 (2010).
    • (2010) Autoimmunity , vol.43 , Issue.3 , pp. 204-209
    • Rizza, P.1    Moretti, F.2    Belardelli, F.3
  • 6
    • 45749099654 scopus 로고    scopus 로고
    • Adjuvant activity of type I interferons
    • DOI 10.1515/BC.2008.051
    • Tovey MG, Lallemand C, Thyphronitis G. Adjuvant activity of type I interferons. Biol. Chem. 389(5), 541-545 (2008). (Pubitemid 351874185)
    • (2008) Biological Chemistry , vol.389 , Issue.5 , pp. 541-545
    • Tovey, M.G.1    Lallemand, C.2    Thyphronitis, G.3
  • 7
    • 42049096991 scopus 로고    scopus 로고
    • Type I interferons as vaccine adjuvants against infectious diseases and cancer
    • DOI 10.1586/14760584.7.3.373
    • Bracci L, La Sorsa V, Belardelli F, Proietti E. Type I interferons as vaccine adjuvants against infectious diseases and cancer. Expert Rev. Vaccines 7(3), 373-381 (2008). (Pubitemid 351520025)
    • (2008) Expert Review of Vaccines , vol.7 , Issue.3 , pp. 373-381
    • Bracci, L.1    La Sorsa, V.2    Belardelli, F.3    Proietti, E.4
  • 8
    • 77956681345 scopus 로고    scopus 로고
    • Interferons as potential adjuvants in prophylactic vaccines
    • Toporovski R, Morrow MP, Weiner DB. Interferons as potential adjuvants in prophylactic vaccines. Expert. Opin. Biol. Ther. 10(10), 1489-1500 (2010).
    • (2010) Expert. Opin. Biol. Ther. , vol.10 , Issue.10 , pp. 1489-1500
    • Toporovski, R.1    Morrow, M.P.2    Weiner, D.B.3
  • 9
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 237(5963), 291-295 (2010).
    • (2010) Science , vol.237 , Issue.5963 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 10
    • 0030036342 scopus 로고    scopus 로고
    • Induction of bystander T cell proliferation by viruses and type I interferon in vivo
    • Tough DF, Borrow P, Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272(5270), 1947-1950 (1996). (Pubitemid 26234507)
    • (1996) Science , vol.272 , Issue.5270 , pp. 1947-1950
    • Tough, D.F.1    Borrow, P.2    Sprent, J.3
  • 11
    • 0032433054 scopus 로고    scopus 로고
    • Type I interferon-mediated stimulation of T cells by CpG DNA
    • DOI 10.1084/jem.188.12.2335
    • Sun S, Zhang X, Tough DF, Sprent J. Type I interferon-mediated stimulation of T cells by CpG DNA. J. Exp. Med. 188(12), 2335-2342 (1998). (Pubitemid 29028505)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.12 , pp. 2335-2342
    • Sun, S.1    Zhang, X.2    Tough, D.F.3    Sprent, J.4
  • 13
    • 0033546053 scopus 로고    scopus 로고
    • The nature of the principal type I interferon-producing cells in human blood
    • Siegal FP, Kadowaki N, Shodell M et al. The nature of the principal type I interferon-producing cells in human blood. Science 284(5421), 1835-1837 (1999).
    • (1999) Science , vol.284 , Issue.5421 , pp. 1835-1837
    • Siegal, F.P.1    Kadowaki, N.2    Shodell, M.3
  • 15
    • 75749138095 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Key players in the initiation and regulation of immune responses
    • Lande R, Gilliet M. Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses. Ann. NY Acad. Sci. 1183, 89-103 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1183 , pp. 89-103
    • Lande, R.1    Gilliet, M.2
  • 16
    • 39049165088 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history
    • Fitzgerald-Bocarsly P, Dai J, Singh S. Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev. 19(1), 3-19 (2008).
    • (2008) Cytokine Growth Factor Rev. , vol.19 , Issue.1 , pp. 3-19
    • Fitzgerald-Bocarsly, P.1    Dai, J.2    Singh, S.3
  • 17
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet M, Cao W, Liu YJ. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8(8), 594-606 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , Issue.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 18
    • 0035030376 scopus 로고    scopus 로고
    • Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo
    • DOI 10.1016/S1074-7613(01)00126-1
    • Le Bon A, Schiavoni G, D'antigenostino G, Gresser I, Belardelli F, Tough DF. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14(4), 461-470 (2001). (Pubitemid 32441598)
    • (2001) Immunity , vol.14 , Issue.4 , pp. 461-470
    • Le Bon, A.1    Schiavoni, G.2    D'Agostino, G.3    Gresser, I.4    Belardelli, F.5    Tough, D.F.6
  • 19
    • 0031656896 scopus 로고    scopus 로고
    • Interferon-α and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells
    • Paquette RL, Hsu NC, Kiertscher SM et al. Interferon-α and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells. J. Leukoc. Biol. 64(3), 358-367 (1998). (Pubitemid 28409243)
    • (1998) Journal of Leukocyte Biology , vol.64 , Issue.3 , pp. 358-367
    • Paquette, R.L.1    Hsu, N.C.2    Kiertscher, S.M.3    Park, A.N.4    Tran, L.5    Roth, M.D.6    Glaspy, J.A.7
  • 20
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus
    • DOI 10.1126/science.1064890
    • Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus. Science 294(5546), 1540-1543 (2001). (Pubitemid 33063928)
    • (2001) Science , vol.294 , Issue.5546 , pp. 1540-1543
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3    Pascual, V.4    Banchereau, J.5
  • 21
    • 17644449715 scopus 로고    scopus 로고
    • Expression of CCR-7 MIP-3β and Th-1 chemokines in type I IFN-induced monocyte- derived dendritic cells: Importance for the rapid acquisition of potent migratory and functional activities
    • Parlato S, Santini SM, Lapenta C et al. Expression of CCR-7, MIP-3β, and Th-1 chemokines in type I IFN-induced monocyte- derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities. Blood 98(10), 3022-3029 (2001).
    • (2001) Blood , vol.98 , Issue.10 , pp. 3022-3029
    • Parlato, S.1    Santini, S.M.2    Lapenta, C.3
  • 23
    • 0042662852 scopus 로고    scopus 로고
    • Potent immune response against HIV-1 and protection from virus challenge in hu-PBL-SCID mice immunized with inactivated virus-pulsed dendritic cells generated in the presence of IFN-α
    • DOI 10.1084/jem.20021924
    • Lapenta C, Santini SM, Logozzi M et al. Potent immune response against HIV-1 and protection from virus challenge in hu-PBL-SCID mice immunized with inactivated-virus-pulsed dendritic cells generated in the presence of IFN-α. J. Exp. Med. 198(2), 361-367 (2003). (Pubitemid 36987861)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.2 , pp. 361-367
    • Lapenta, C.1    Santini, S.M.2    Logozzi, M.3    Spada, M.4    Andreotti, M.5    Di Pucchio, T.6    Parlato, S.7    Belardelli, F.8
  • 26
    • 1642541167 scopus 로고    scopus 로고
    • IFN-α promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment
    • DOI 10.1182/blood-2003-03-0981
    • Gabriele L, Borghi P, Rozera C et al. IFN-α promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment. Blood 103(3), 980-987 (2004). (Pubitemid 38129560)
    • (2004) Blood , vol.103 , Issue.3 , pp. 980-987
    • Gabriele, L.1    Borghi, P.2    Rozera, C.3    Sestili, P.4    Andreotti, M.5    Guarini, A.6    Montefusco, E.7    Foa, R.8    Belardelli, F.9
  • 27
    • 33744521498 scopus 로고    scopus 로고
    • The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu
    • DOI 10.1016/j.vaccine.2006.04.010, PII S0264410X06004373
    • Salem ML, El-Naggar SA, Kadima A, Gillanders WE, Cole DJ. The adjuvant effects of the Toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine 24(24), 5119-5132 (2006). (Pubitemid 43818196)
    • (2006) Vaccine , vol.24 , Issue.24 , pp. 5119-5132
    • Salem, M.L.1    El-Naggar, S.A.2    Kadima, A.3    Gillanders, W.E.4    Cole, D.J.5
  • 28
    • 84868547474 scopus 로고    scopus 로고
    • Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques
    • Stahl-Hennig C, Eisenblätter M, Jasny E et al. Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques. PLoS Pathog. 5(4), e1000373 (2009).
    • (2009) PLoS Pathog. , vol.5 , Issue.4
    • Stahl-Hennig, C.1    Eisenblätter, M.2    Jasny, E.3
  • 31
    • 77953502765 scopus 로고    scopus 로고
    • + dendritic cells DCs represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    • + (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J. Exp. Med. 207(6), 1247-1260 (2010).
    • (2010) J. Exp. Med. , vol.207 , Issue.6 , pp. 1247-1260
    • Jongbloed, S.L.1    Kassianos, A.J.2    McDonald, K.J.3
  • 36
    • 34548694962 scopus 로고    scopus 로고
    • Innate recognition of viruses
    • DOI 10.1016/j.immuni.2007.08.012, PII S1074761307004189
    • Pichlmair A, Reis e Sousa C. Innate recognition of viruses. Immunity 27(3), 370-383 (2007). (Pubitemid 47418682)
    • (2007) Immunity , vol.27 , Issue.3 , pp. 370-383
    • Pichlmair, A.1    Reis E Sousa, C.2
  • 37
    • 67649884707 scopus 로고    scopus 로고
    • Beyond a decade of 5% imiquimod topical therapy
    • Gaspari AA, Tyring SK, Rosen T. Beyond a decade of 5% imiquimod topical therapy. J. Drugs Dermatol. 8(5), 467-474 (2009).
    • (2009) J. Drugs Dermatol. , vol.8 , Issue.5 , pp. 467-474
    • Gaspari, A.A.1    Tyring, S.K.2    Rosen, T.3
  • 38
    • 77950490375 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists
    • Rajagopal D, Paturel C, Morel Y, Uematsu S, Akira S, Diebold SS. Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists. Blood 115(10), 1949-1957 (2010).
    • (2010) Blood , vol.115 , Issue.10 , pp. 1949-1957
    • Rajagopal, D.1    Paturel, C.2    Morel, Y.3    Uematsu, S.4    Akira, S.5    Diebold, S.S.6
  • 39
    • 0037438664 scopus 로고    scopus 로고
    • Down-modulation of responses to type I IFN upon T cell activation
    • Dondi E, Rogge L, Lutfalla G, Uze G, Pellegrini S. Down-modulation of responses to type I IFN upon T cell activation. J. Immunol. 170(2), 749-756 (2003). (Pubitemid 36070525)
    • (2003) Journal of Immunology , vol.170 , Issue.2 , pp. 749-756
    • Dondi, E.1    Rogge, L.2    Lutfalla, G.3    Uze, G.4    Pellegrini, S.5
  • 40
    • 33646451493 scopus 로고    scopus 로고
    • A and l interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus
    • Chi B, Dickensheets HL, Spann KM et al. a and l interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus. J. Virol. 80(10), 5032-5040 (2006).
    • (2006) J. Virol. , vol.80 , Issue.10 , pp. 5032-5040
    • Chi, B.1    Dickensheets, H.L.2    Spann, K.M.3
  • 42
    • 33644837684 scopus 로고    scopus 로고
    • Cutting edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection
    • Havenar-Daughton C, Kolumam GA, Murali-Krishna K. Cutting edge: the direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J. Immunol. 176(6), 3315-3319 (2006). (Pubitemid 43363977)
    • (2006) Journal of Immunology , vol.176 , Issue.6 , pp. 3315-3319
    • Havenar-Daughton, C.1    Kolumam, G.A.2    Murali-Krishna, K.3
  • 43
    • 0037388926 scopus 로고    scopus 로고
    • Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells
    • DOI 10.1084/jem.20021091
    • Krug A, Veeraswamy R, Pekosz A et al. Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. J. Exp. Med. 197(7), 899-906 (2003). (Pubitemid 36437866)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.7 , pp. 899-906
    • Krug, A.1    Veeraswamy, R.2    Pekosz, A.3    Kanagawa, O.4    Unanue, E.R.5    Colonna, M.6    Cella, M.7
  • 46
    • 77953375467 scopus 로고    scopus 로고
    • APC activation by IFN-α decreases regulatory T cell and enhances Th cell functions
    • Pace L, Vitale S, Dettori B et al. APC activation by IFN-α decreases regulatory T cell and enhances Th cell functions. J. Immunol. 184(11), 5969-5979 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.11 , pp. 5969-5979
    • Pace, L.1    Vitale, S.2    Dettori, B.3
  • 47
    • 77955526258 scopus 로고    scopus 로고
    • Regulatory T cell frequency in patients with melanoma with different disease stage and course and modulating effects of high-dose interferon-α 2b treatment
    • Ascierto PA, Napolitano M, Celentano E et al. Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-α 2b treatment. J. Transl. Med. 8, 76 (2010).
    • (2010) J. Transl. Med. , vol.8 , pp. 76
    • Ascierto, P.A.1    Napolitano, M.2    Celentano, E.3
  • 48
    • 57849085182 scopus 로고    scopus 로고
    • Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    • Querec TD, Akondy RS, Lee EK et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat. Immunol. 10(1), 116-125 (2009).
    • (2009) Nat. Immunol. , vol.10 , Issue.1 , pp. 116-125
    • Querec, T.D.1    Akondy, R.S.2    Lee, E.K.3
  • 49
    • 59649129816 scopus 로고    scopus 로고
    • Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
    • Gaucher D, Therrien R, Kettaf N et al. Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J. Exp. Med. 205(13), 3119-3131 (2008).
    • (2008) J. Exp. Med. , vol.205 , Issue.13 , pp. 3119-3131
    • Gaucher, D.1    Therrien, R.2    Kettaf, N.3
  • 50
  • 52
    • 33645214607 scopus 로고    scopus 로고
    • Adjuvant activity of interferon a: Mechanism s of action
    • S2-
    • Tovey MG, Lallemand C, Meritet JF, Maury C. Adjuvant activity of interferon a: mechanism(s) of action. Vaccine 24(Suppl. 2), S2-46-47 (2006).
    • (2006) Vaccine , vol.24 , Issue.2 , pp. 46-47
    • Tovey, M.G.1    Lallemand, C.2    Meritet, J.F.3    Maury, C.4
  • 53
    • 16244389282 scopus 로고    scopus 로고
    • Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level
    • DOI 10.1016/j.vaccine.2004.12.006
    • Bracci L, Canini I, Puzelli S et al. Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level. Vaccine 23(23), 2994-3004 (2005). (Pubitemid 40462438)
    • (2005) Vaccine , vol.23 , Issue.23 , pp. 2994-3004
    • Bracci, L.1    Canini, I.2    Puzelli, S.3    Sestili, P.4    Venditti, M.5    Spada, M.6    Donatelli, I.7    Belardelli, F.8    Proietti, E.9
  • 54
    • 0036772786 scopus 로고    scopus 로고
    • Coimmunisation with type I IFN genes enhances protective immunity against cytomegalovirus and myocarditis in gB DNA-vaccinated mice
    • DOI 10.1038/sj.gt.3301809
    • Cull VS, Broomfield S, Bartlett EJ, Brekalo NL, James CM. Coimmunisation with type I IFN genes enhances protective immunity against cytomegalovirus and myocarditis in gB DNA-vaccinated mice. Gene Ther. 9(20), 1369-1378 (2002). (Pubitemid 35244162)
    • (2002) Gene Therapy , vol.9 , Issue.20 , pp. 1369-1378
    • Cull, V.S.1    Broomfield, S.2    Bartlett, E.J.3    Brekalo, N.L.4    James, C.M.5
  • 55
    • 0021257131 scopus 로고
    • Interferon as an adjuvant for hepatitis B vaccination in non- and low-responder populations
    • Grob PJ, Joller-Jemelka HI, Binswanger U, Zaruba K, Descoeudres C, Fernex M. Interferon as an adjuvant for hepatitis B vaccination in non- and low-responder populations. Eur. J. Clin. Microbiol. 3(3), 195-198 (1984). (Pubitemid 14064343)
    • (1984) European Journal of Clinical Microbiology , vol.3 , Issue.3 , pp. 195-198
    • Grob, P.J.1    Joller-Jemelka, H.I.2    Binswanger, U.3
  • 56
    • 0024436828 scopus 로고
    • Effects of interferons on immune response to a synthetic peptide malaria sporozoite vaccine in non-immune adults
    • DOI 10.1016/0264-410X(89)90162-X
    • Strchler D, Berger R, Etlinger H et al. Effects of interferons on immune response to a synthetic peptide malaria sporozoite vaccine in non-immune adults. Vaccine 7(5), 457-461 (1989). (Pubitemid 19252631)
    • (1989) Vaccine , vol.7 , Issue.5 , pp. 457-461
    • Sturchler, D.1    Berger, R.2    Etlinger, H.3    Fernex, M.4    Matile, H.5    Pink, R.6    Schlumbom, V.7    Just, M.8
  • 57
    • 0028222854 scopus 로고
    • Randomized comparative trial of interferon-α versus placebo in hepatitis B vaccine non-responders and hyporesponders
    • DOI 10.1016/0264-410X(94)90116-3
    • Goldwater PN. Randomized comparative trial of interferon-α versus placebo in hepatitis B vaccine non-responders and hyporesponders. Vaccine 12(5), 410-414 (1994). (Pubitemid 24107577)
    • (1994) Vaccine , vol.12 , Issue.5 , pp. 410-414
    • Goldwater, P.N.1
  • 58
    • 39149107091 scopus 로고    scopus 로고
    • Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals
    • Rizza P, Capone I, Urbani F et al. Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals. Vaccine 26(8), 1038-1049 (2008).
    • (2008) Vaccine , vol.26 , Issue.8 , pp. 1038-1049
    • Rizza, P.1    Capone, I.2    Urbani, F.3
  • 59
    • 33744492302 scopus 로고    scopus 로고
    • Interferon-1-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells
    • DOI 10.1182/blood-2005-10-4129
    • Mennechet FJ, Uzè G. Interferon-l-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells. Blood 107(11), 4417-4423 (2006). (Pubitemid 43801368)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4417-4423
    • Mennechet, F.J.D.1    Uze, G.2
  • 60
    • 67651115867 scopus 로고    scopus 로고
    • Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity
    • Morrow MP, Pankhong P, Laddy DJ et al. Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity. Blood 113(23), 5868-5877 (2009).
    • (2009) Blood , vol.113 , Issue.23 , pp. 5868-5877
    • Morrow, M.P.1    Pankhong, P.2    Laddy, D.J.3
  • 61
    • 68949170684 scopus 로고    scopus 로고
    • Recombinant interferon-a2b improves immune response to hepatitis B vaccination in haemodialysis patients: Results of a randomised clinical trial
    • Miquilena-Colina ME, Lozano- Rodríguez T, García-Pozo L et al. Recombinant interferon-a2b improves immune response to hepatitis B vaccination in haemodialysis patients: results of a randomised clinical trial. Vaccine 27(41), 5654-5660 (2009).
    • (2009) Vaccine , vol.27 , Issue.41 , pp. 5654-5660
    • Miquilena-Colina, M.E.1    Lozano- Rodríguez, T.2    García-Pozo, L.3
  • 64
    • 47149095735 scopus 로고    scopus 로고
    • Effect of sublingual administration of interferon-α on the immune response to influenza vaccination in institutionalized elderly individuals
    • Launay O, Grabar S, Bloch F et al. Effect of sublingual administration of interferon-α on the immune response to influenza vaccination in institutionalized elderly individuals. Vaccine 26(32), 4073-4079 (2008).
    • (2008) Vaccine , vol.26 , Issue.32 , pp. 4073-4079
    • Launay, O.1    Grabar, S.2    Bloch, F.3
  • 65
    • 68449089230 scopus 로고    scopus 로고
    • Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans
    • Couch RB, Atmar RL, Cate TR et al. Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans. Vaccine 27(39), 5344-5348 (2009).
    • (2009) Vaccine , vol.27 , Issue.39 , pp. 5344-5348
    • Couch, R.B.1    Atmar, R.L.2    Cate, T.R.3
  • 66
    • 72449141577 scopus 로고    scopus 로고
    • Redefining the role of interferon in the treatment of malignant diseases
    • Bracarda S, Eggermont AM, Samuelsson J. Redefining the role of interferon in the treatment of malignant diseases. Eur. J. Cancer. 46(2), 284-297 (2010).
    • (2010) Eur. J. Cancer. , vol.46 , Issue.2 , pp. 284-297
    • Bracarda, S.1    Eggermont, A.M.2    Samuelsson, J.3
  • 67
    • 0033941331 scopus 로고    scopus 로고
    • Gene therapy of cancer with interferon: Lessons from tumor models and perspectives for clinical applications
    • DOI 10.1006/scbi.2000.0333
    • Ferrantini M, Belardelli F. Gene therapy of cancer with interferon: lessons from tumor models and perspectives for clinical applications. Semin. Cancer. Biol. 10(2), 145-157 (2000). (Pubitemid 30458474)
    • (2000) Seminars in Cancer Biology , vol.10 , Issue.2 , pp. 145-157
    • Ferrantini, M.1    Belardelli, F.2
  • 68
    • 34347272251 scopus 로고    scopus 로고
    • Interferon-α and cancer: Mechanisms of action and new perspectives of clinical use
    • DOI 10.1016/j.biochi.2007.04.006, PII S0300908407001010
    • Ferrantini M, Capone I, Belardelli F. Interferon-α and cancer: mechanisms of action and new perspectives of clinical use. Biochimie 89(6-7), 884-893 (2007). (Pubitemid 47001642)
    • (2007) Biochimie , vol.89 , Issue.6-7 , pp. 884-893
    • Ferrantini, M.1    Capone, I.2    Belardelli, F.3
  • 69
    • 67649220219 scopus 로고    scopus 로고
    • + T cell numbers effector function and antitumor activity
    • + T cell numbers, effector function, and antitumor activity. J. Immunol. 182(12), 7398-7407 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.12 , pp. 7398-7407
    • Sikora, A.G.1    Jaffarzad, N.2    Hailemichael, Y.3
  • 70
    • 65249143324 scopus 로고    scopus 로고
    • The antitumor and immunoadjuvant effects of IFN-α in combination with recombinant poxvirus vaccines
    • Hance KW, Rogers CJ, Zaharoff DA, Canter D, Schlom J, Greiner JW. The antitumor and immunoadjuvant effects of IFN-α in combination with recombinant poxvirus vaccines. Clin. Cancer Res. 15(7), 2387-2396 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.7 , pp. 2387-2396
    • Hance, K.W.1    Rogers, C.J.2    Zaharoff, D.A.3    Canter, D.4    Schlom, J.5    Greiner, J.W.6
  • 72
    • 38449088518 scopus 로고    scopus 로고
    • Type I interferon in systemic lupus erythematosus
    • Crow MK. Type I interferon in systemic lupus erythematosus. Curr. Top. Microbiol. Immunol. 316, 359-386 (2007).
    • (2007) Curr. Top. Microbiol. Immunol. , vol.316 , pp. 359-386
    • Crow, M.K.1
  • 73
    • 33748447541 scopus 로고    scopus 로고
    • Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases
    • DOI 10.1016/j.immuni.2006.08.010, PII S1074761306003955
    • Banchereau J, Pascual V. Type I IFN in systemic lupus erythematosus and other autoimmune diseases. Immunity 25(3), 383-392 (2006). (Pubitemid 44354221)
    • (2006) Immunity , vol.25 , Issue.3 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 74
    • 32644477012 scopus 로고    scopus 로고
    • Autoimmunity and immunotherapy of cancer
    • Koon H, Atkins M. Autoimmunity and immunotherapy of cancer. N. Engl. J. Med. 354(7), 758-760 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.7 , pp. 758-760
    • Koon, H.1    Atkins, M.2
  • 75
    • 33646400810 scopus 로고    scopus 로고
    • + T cells and monocyte/dendritic cell precursors
    • + T cells and monocyte/dendritic cell precursors. Cancer Res. 66(9), 4943-4951 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.9 , pp. 4943-4951
    • Di Pucchio, T.1    Pilla, L.2    Capone, I.3
  • 76
    • 63149171153 scopus 로고    scopus 로고
    • Immunogenicity and antitumor effects of vaccination with peptide vaccine+/- granulocyte-monocyte colony-stimulating factor and/or IFN-a2b in advanced metastatic melanoma: Eastern cooperative oncology group phase ii trial e1696
    • Kirkwood JM, Lee S, Moschos SJ et al. Immunogenicity and antitumor effects of vaccination with peptide vaccine+/- granulocyte-monocyte colony-stimulating factor and/or IFN-a2b in advanced metastatic melanoma: Eastern Cooperative Oncology Group Phase II Trial E1696. Clin. Cancer Res. 15(4), 1443-1451 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.4 , pp. 1443-1451
    • Kirkwood, J.M.1    Lee, S.2    Moschos, S.J.3
  • 77
    • 33847789122 scopus 로고    scopus 로고
    • The CD14+ CD16+ blood monocytes: Their role in infection and inflammation
    • DOI 10.1189/jlb.0806510
    • + blood monocytes: their role in infection and inflammation. J. Leukoc. Biol. 81(3), 584-592 (2007). (Pubitemid 46393535)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.3 , pp. 584-592
    • Ziegler-Heitbrock, L.1
  • 79
    • 71849085783 scopus 로고    scopus 로고
    • Induction of IP-10/CXCL10 secretion as an immunomodulatory effect of low-dose adjuvant interferon-α during treatment of melanoma
    • Mohty AM, Grob JJ, Mohty M, Richard MA, Olive D, Gaugler B. Induction of IP-10/CXCL10 secretion as an immunomodulatory effect of low-dose adjuvant interferon-α during treatment of melanoma. Immunobiology 215(2), 113-123 (2010).
    • (2010) Immunobiology , vol.215 , Issue.2 , pp. 113-123
    • Mohty, A.M.1    Grob, J.J.2    Mohty, M.3    Richard, M.A.4    Olive, D.5    Gaugler, B.6
  • 80
    • 58149376993 scopus 로고    scopus 로고
    • Chemotherapy enhances vaccine-induced antitumor immunity in melanoma patients
    • Nisticò P, Capone I, Palermo B et al. Chemotherapy enhances vaccine-induced antitumor immunity in melanoma patients. Int. J. Cancer. 124(1), 130-139 (2009).
    • (2009) Int. J. Cancer. , vol.124 , Issue.1 , pp. 130-139
    • Nisticò, P.1    Capone, I.2    Palermo, B.3
  • 81
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • DOI 10.1038/nature06175, PII NATURE06175
    • Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 449(7161), 419-426 (2007). (Pubitemid 47509552)
    • (2007) Nature , vol.449 , Issue.7161 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 82
    • 77949881623 scopus 로고    scopus 로고
    • LOX-1 as a natural IFN-α-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells
    • Parlato S, Romagnoli G, Spadaro F et al. LOX-1 as a natural IFN-α-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells. Blood 115(8), 1554-1563 (2010).
    • (2010) Blood , vol.115 , Issue.8 , pp. 1554-1563
    • Parlato, S.1    Romagnoli, G.2    Spadaro, F.3
  • 83
    • 79952109911 scopus 로고    scopus 로고
    • Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α
    • Rouzaut A, Garasa S, Teijeira A et al. Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α. Eur. J. Immunol. 40(11) 3054-3063 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , Issue.11 , pp. 3054-3063
    • Rouzaut, A.1    Garasa, S.2    Teijeira, A.3
  • 84
    • 78651404452 scopus 로고    scopus 로고
    • Spontaneous regression of highly immunogenic molluscum contagiosum virus MCV-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration
    • Vermi W, Fisogni S, Salogni L et al. Spontaneous regression of highly immunogenic molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J. Invest. Dermatol. 131(2) 426-434 (2010).
    • (2010) J. Invest. Dermatol. , vol.131 , Issue.2 , pp. 426-434
    • Vermi, W.1    Fisogni, S.2    Salogni, L.3
  • 85
    • 77951847280 scopus 로고    scopus 로고
    • Combination strategies for enhancing the efficacy of immunotherapy in cancer patients
    • Moschella F, Proietti E, Capone I, Belardelli F. Combination strategies for enhancing the efficacy of immunotherapy in cancer patients. Ann. NY Acad. Sci. 1194, 169-178 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1194 , pp. 169-178
    • Moschella, F.1    Proietti, E.2    Capone, I.3    Belardelli, F.4
  • 86
    • 78049523304 scopus 로고    scopus 로고
    • Desirable cell death during anticancer chemotherapy
    • Locher C, Conforti R, Aymeric L et al. Desirable cell death during anticancer chemotherapy. Ann. NY Acad. Sci. 1209, 99-108 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1209 , pp. 99-108
    • Locher, C.1    Conforti, R.2    Aymeric, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.