Type I interferon (IFNα) acts directly on human memory CD4 + T cells altering their response to antigen

Journal of Immunology

Volumn 183, Issue 5, 2009, Pages 2915-2920

  Gallagher, Kathleen M E ^a   Lauder, Sarah ^a   Rees, Ian W ^a   Gallimore, Awen M ^a   Godkin, Andrew J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD45RO ANTIGEN; GAMMA INTERFERON; HEMAGGLUTININ; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RECOMBINANT ALPHA2A INTERFERON; TETANUS TOXOID; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA; ALPHA INTERFERON; INFLUENZA VIRUS HEMAGGLUTININ;

ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYTOKINE PRODUCTION; HEPATITIS C; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MONONUCLEAR CELL; PATHOLOGY; PHYSIOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNOLOGIC MEMORY; INJECTIONS, SUBCUTANEOUS; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; TETANUS TOXOID; TUBERCULIN;

EID: 70349257382     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0801607     Document Type: Article

References (23)

1. Gattoni, A., A. Parlato, B. Vangieri, M. Bresciani, and R. Derna. 2006. Interferon-γ: biologic functions and HCV terapy (type I/II) (2 of 2 parts). La Clinica Terapeutica 157: 457-468. (Pubitemid 44905230)
2. Gattoni, A., A. Parlato, B. Vangieri, M. Bresciani, and R. Derna. 2006. Interferon-γ: biologic functions and HCV therapy (type I/II) (1 of 2 parts). La Clinica Terapeutica 157: 377-386. (Pubitemid 44922316)
3. Ossendorp, F., E. Mengede, M. Camps, R. Filius, and C. J. Melief. 1998. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J. Exp. Med. 187: 693-702.
4. Baccala, R., D. H. Kono, and A. N. Theofilopoulos. 2005. Interferons as pathogenic effectors in autoimmunity. Immunol. Rev. 204: 9-26.
5. Biron, C. A. 2001. Intferons α and β as immune regulators- a new look. Immunity 14: 661-664.
6. Soumelis, V., and Y. J. Liu. 2006. From plasmacytoid to dendritic cell: morphological and functional switches during plasmacytoid pre-dendritic cell differentiation. Eur. J. Immunol. 36: 2286-2292.
7. Farrar, J. D., J. D. Smith, T. L. Murphy, S. Leung, G. R. Stark, and K. M. Murphy. 2000. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat. Immunol. 1: 65-69.
8. O'Shea, J. J., and R. Visconti. 2000. Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat. Immunol. 1: 17-19.
9. Rogge, L., D. D'Ambrosio, M. Biffi, G. Penna, L. J. Minetti, D. H. Presky, L. Adorini, and F. Sinigaglia. 1998. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J. Immunol. 161: 6567-6574.
10. + T cells and monocytes. Blood 87: 4731-4736.
11. + T cells. J. Exp. Med. 178: 1655-1663.
12. Dondi, E., L. Rogge, G. Lutfalla, G. Uze, and S. Pellegrini. 2003. Down-modulation of responses to type I IFN upon T cell activation. J. Immunol. 170: 749-756. (Pubitemid 36070525)
13. Eriksen, K. W., V. H. Sommer, A. Woetmann, A. B. Rasmussen, C. Brender, A. Svejgaard, S. Skov, C. Geisler, and N. Odum. 2004. Bi-phasic effect of interferon (IFN)-α: IFN-α up- and down-regulates interleukin-4 signaling in human T cells. J. Biol. Chem. 279: 169-176.
14. Krug, A., R. Veeraswamy, A. Pekosz, O. Kanagawa, E. R. Unanue, M. Colonna, and M. Cella. 2003. Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. J. Exp. Med. 197: 899-906.
15. Marrack, P., J. Kappler, and T. Mitchell. 1999. Type I interferons keep activated T cells alive. J. Exp. Med. 189: 521-530.
16. Matikainen, S., T. Sareneva, T. Ronni, A. Lehtonen, P. J. Koskinen, and I. Julkunen. 1999. Interferon-α activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells. Blood 93: 1980-1991.
17. + T cells. Blood 89: 1110-1111.
18. Tough, D. F., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179: 1127-1135.
19. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272: 54-60. (Pubitemid 26110754)
20. Chi, B., H. L. Dickensheets, K. M. Spann, M. A. Alston, C. Luongo, L. Dumoutier, J. Huang, J. C. Renauld, S. V. Kotenko, M. Roederer, J. A. Beeler, et al. 2006. Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus. J. Virol. 80: 5032-5040.
21. Unutmaz, D., P. Pileri, and S. Abrignani. 1994. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180: 1159-1164.
22. Havenar-Daughton, C., G. A. Kolumam, and K. Murali-Krishna. 2006. Cutting edge: the direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J. Immunol. 176: 3315-3319.
23. + T cell turnover in vivo by IL-12, IL-18, and IFN-γ. J. Immunol. 166: 6007-6011.