Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 3, 2011, Pages

  Lemarié, Catherine A ^a   Shbat, Layla ^a   Marchesi, Chiara ^a   Angulo, Orlando J ^a   Deschênes, Marie Eve ^a   Blostein, Mark D ^a,b   Paradis, Pierre ^a   Schiffrin, Ernesto L ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Endothelium; Homocysteine; Methylenetetrahydrofolate reductase; Telomeres

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ENDOTHELIAL NITRIC OXIDE SYNTHASE; HOMOCYSTEINE; MONOMER; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SEPIAPTERIN; SIRTUIN 1;

AMINO ACID BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CELL DIFFERENTIATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ENZYME DEFICIENCY; FEMALE; GENE DELETION; HETEROZYGOSITY; HYPERHOMOCYSTEINEMIA; METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TELOMERE;

ANIMALS; CELL AGING; CELL DIFFERENTIATION; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; HOMOCYSTINURIA; HYPERHOMOCYSTEINEMIA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MUSCLE SPASTICITY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PSYCHOTIC DISORDERS; PTERINS; REACTIVE OXYGEN SPECIES; SIRTUIN 1; STEM CELLS; TELOMERE;

EID: 79955061886     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00321.2010     Document Type: Article

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