Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain

Journal of Cellular Physiology

Volumn 226, Issue 7, 2011, Pages 1722-1726

  Sunmonu, N Abimbola ^a   Li, Kairong ^a   Li, James Y H ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 8; ISOPROTEIN;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; BRAIN DEVELOPMENT; EMBRYO DEVELOPMENT; FGF 8 GENE; GENE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; REVIEW; VERTEBRATE;

ANIMALS; BRAIN; CELL DIFFERENTIATION; CELL PROLIFERATION; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTORS; HUMANS; MICE; MORPHOGENESIS; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIGNAL TRANSDUCTION; ZEBRAFISH PROTEINS;

NEMATODA; VERTEBRATA;

EID: 79955029469     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22587     Document Type: Review

References (64)

1. Alvarado-Mallart RM. 1993. Fate and potentialities of the avian mesencephalic/metencephalic neuroepithelium. J Neurobiol 24:1341-1355.
2. Asada M, Yoneda A, Oda Y, Ota K, Ozawa K, Fukuta K, Omae F, Asanagi M, Orikasa N, Suzuki M, Oka S, Makino T, Imamura T. 1999. Characterization of fibroblast growth factor-6 expressed by Chinese hamster ovary cells as a glycosylated mitogen for human vascular endothelial cells. Growth Factors 16:293-303.
3. Bellosta P, Talarico D, Rogers D, Basilico C. 1993. Cleavage of K-FGF produces a truncated molecule with increased biological activity and receptor binding affinity. J Cell Biol 121:705-713.
4. Blunt AG, Lawshe A, Cunningham ML, Seto ML, Ornitz DM, MacArthur CA. 1997. Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands. J Biol Chem 272:3733-3738.
5. Brondani V, Hamy F. 2000. Retinoic acid switches differential expression of FGF8 isoforms in LNCaP cells. Biochem Biophys Res Commun 272:98-103.
6. Brondani V, Klimkait T, Egly JM, Hamy F. 2002. Promoter of FGF8 reveals a unique regulation by unliganded RARalpha. J Mol Biol 319:715-728.
7. Chi CL, Martinez S, Wurst W, Martin GR. 2003. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development 130:2633-2644.
8. Crossley PH, Martin GR. 1995. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121:439-451.
9. Crossley PH, Martinez S, Martin GR. 1996. Midbrain development induced by FGF8 in the chick embryo. Nature 380:66-68.
10. Crossley PH, Martinez S, Ohkubo Y, Rubenstein JL. 2001. Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles. Neuroscience 108:183-206.
11. Diez del Corral R, Olivera-Martinez I, Goriely A, Gale E, Maden M, Storey K. 2003. Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron 40:65-79.
12. Dubrulle J, Pourquie O. 2004. fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature 427:419-422.
13. Duraisamy Y, Slevin M, Smith N, Bailey J, Zweit J, Smith C, Ahmed N, Gaffney J. 2001. Effect of glycation on basic fibroblast growth factor induced angiogenesis and activation of associated signal transduction pathways in vascular endothelial cells: Possible relevance to wound healing in diabetes. Angiogenesis 4:277-288.
14. Eriksson AE, Cousens LS, Weaver LH, Matthews BW. 1991. Three-dimensional structure of human basic fibroblast growth factor. Proc Natl Acad Sci USA 88:3441-3445.
15. Falardeau J, Chung WC, Beenken A, Raivio T, Plummer L, Sidis Y, Jacobson-Dickman EE, Eliseenkova AV, Ma J, Dwyer A, Quinton R, Na S, Hall JE, Huot C, Alois N, Pearce SH, Cole LW, Hughes V, Mohammadi M, Tsai P, Pitteloud N. 2008. Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J Clin Invest 118:2822-2831.
16. Fletcher RB, Baker JC, Harland RM. 2006. FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus. Development 133:1703-1714.
17. Frank DU, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM. 2002. An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development 129:4591-4603.
18. Garel S, Huffman KJ, Rubenstein JL. 2003. Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development 130:1903-1914.
19. Gemel J, Gorry M, Ehrlich GD, MacArthur CA. 1996. Structure and sequence of human FGF8. Genomics 35:253-257.
20. Ghosh AK, Shankar DB, Shackleford GM, Wu K, T'Ang A, Miller GJ, Zheng J, Roy-Burman P. 1996. Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ 7:1425-1434.
21. Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert TA, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H, Ogawa Y, Kuro-o M, Lanske B, Razzaque MS, Mohammadi M. 2007. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol 27:3417-3428.
22. Goldfarb M. 2005. Fibroblast growth factor homologous factors: Evolution, structure, and function. Cytokine Growth Factor Rev 16:215-220.
23. Gospodarowicz D. 1975. Purification of a fibroblast growth factor from bovine pituitary. J Biol Chem 250:2515-2520.
24. Gospodarowicz D, Jones KL, Sato G. 1974. Purification of a growth factor for ovarian cells from bovine pituitary glands. Proc Natl Acad Sci USA 71:2295-2299.
25. Gospodarowicz D, Bialecki H, Greenburg G. 1978. Purification of the fibroblast growth factor activity from bovine brain. J Biol Chem 253:3736-3743.
26. Guo Q, Li JY. 2007. Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation. Development 134:2251-2260.
27. Guo Q, Li K, Sunmonu NA, Li JY. 2010. Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum. Dev Biol 338:183-192.
28. Haworth KE, Healy C, Sharpe PT. 2005. Characterisation of the genomic structure of chick Fgf8. DNA Seq 16:180-186.
29. Inoue F, Nagayoshi S, Ota S, Islam ME, Tonou-Fujimori N, Odaira Y, Kawakami K, Yamasu K. 2006. Genomic organization, alternative splicing, and multiple regulatory regions of the zebrafish fgf8 gene. Dev Growth Differ 48:447-462.
30. Itoh N, Ornitz DM. 2004. Evolution of the Fgf and Fgfr gene families. Trends Genet 20:563-569.
31. Itoh N, Ornitz DM. 2008. Functional evolutionary history of the mouse Fgf gene family. Dev Dyn 237:18-27.
32. Kawauchi S, Shou J, Santos R, Hebert JM, McConnell SK, Mason I, Calof AL. 2005. Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development 132:5211-5223.
33. Ladher RK, Wright TJ, Moon AM, Mansour SL, Schoenwolf GC. 2005. FGF8 initiates inner ear induction in chick and mouse. Genes Dev 19:603-613.
34. Le Douarin NM. 1993. Embryonic neural chimaeras in the study of brain development. Trends Neurosci 16:64-72.
35. Lee SM, Danielian PS, Fritzsch B, McMahon AP. 1997. Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124:959-969.
36. Lewandoski M, Sun X, Martin GR. 2000. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26:460-463.
37. Liu A, Losos K, Joyner AL. 1999. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development 126:4827-4838.
38. MacArthur CA, Lawshe A, Shankar DB, Heikinheimo M, Shackleford GM. 1995a. FGF-8 isoforms differ in NIH3T3 cell transforming potential. Cell Growth Differ 6:817-825.
39. MacArthur CA, Lawshe A, Xu J, Santos-Ocampo S, Heikinheimo M, Chellaiah AT, Ornitz DM. 1995b. FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 121:3603-3613.
40. Maciag T, Cerundolo J, Ilsley S, Kelley PR, Forand R. 1979. An endothelial cell growth factor from bovine hypothalamus: Identification and partial characterization. Proc Natl Acad Sci USA 76:5674-5678.
41. Martinez-Ferre A, Martinez S. 2009. The development of the thalamic motor learning area is regulated by Fgf8 expression. J Neurosci 29:13389-13400.
42. Meyers EN, Martin GR. 1999. Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH. Science 285:403-406.
43. Meyers EN, Lewandoski M, Martin GR. 1998. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet 18:136-141.
44. Mohammadi M, Olsen SK, Ibrahimi OA. 2005. Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev 16:107-137.
45. Moon AM, Capecchi MR. 2000. Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet 26:455-459.
46. Nugent MA, Edelman ER. 1992. Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: A mechanism for cooperactivity. Biochemistry 31:8876-8883.
47. Olsen SK, Garbi M, Zampieri N, Eliseenkova AV, Ornitz DM, Goldfarb M, Mohammadi M. 2003. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem 278:34226-34236.
48. Olsen SK, Li JY, Bromleigh C, Eliseenkova AV, Ibrahimi OA, Lao Z, Zhang F, Linhardt RJ, Joyner AL, Mohammadi M. 2006. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev 20:185-198.
49. Ornitz DM, Itoh N. 2001. Fibroblast growth factors. Genome Biol 2: REVIEW S3005.
50. Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. 2008. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 40:1413-1415.
51. Perantoni AO, Timofeeva O, Naillat F, Richman C, Pajni-Underwood S, Wilson C, Vainio S, Dove LF, Lewandoski M. 2005. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development 132:3859-3871.
52. Riley BM, Mansilla MA, Ma J, Daack-Hirsch S, Maher BS, Raffensperger LM, Russo ET, Vieira AR, Dode C, Mohammadi M, Marazita ML, Murray JC. 2007. Impaired FGF signaling contributes to cleft lip and palate. Proc Natl Acad Sci USA 104:4512-4517.
53. Sato T, Nakamura H. 2004. The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway. Development 131:4275-4285.
54. Sato T, Araki I, Nakamura H. 2001. Inductive signal and tissue responsiveness defining the tectum and the cerebellum. Development 128:2461-2469.
55. Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M. 2000. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell 6:743-750.
56. Shim S, Bae N, Park SY, Kim WS, Han JK. 2005. Isolation of Xenopus FGF-8b and comparison with FGF-8a. Mol Cells 19:310-317.
57. Storm EE, Rubenstein JL, Martin GR. 2003. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc Natl Acad Sci USA 100:1757-1762.
58. Sun X, Meyers EN, Lewandoski M, Martin GR. 1999. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 13:1834-1846.
59. Tanaka A, Miyamoto K, Minamino N, Takeda M, Sato B, Matsuo H, Matsumoto K. 1992. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci USA 89:8928-8932.
60. Tanaka S, Ueo H, Mafune K, Mori M, Wands JR, Sugimachi K. 2001. A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma. Dig Dis Sci 46:1016-1021.
61. Trarbach EB, Abreu AP, Silveira LF, Garmes HM, Baptista MT, Teles MG, Costa EM, Mohammadi M, Pitteloud N, Mendonca BB, Latronico AC. 2010. Nonsense mutations in FGF8 gene causing different degrees of human gonadotropin-releasing deficiency. J Clin Endocrinol Metab 95:3491-3496.
62. Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR. 1999. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev 13:3136-3148.
63. Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, Mayr C, Kingsmore SF, Schroth GP, Burge CB. 2008. Alternative isoform regulation in human tissue transcriptomes. Nature 456:470-476.
64. Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC. 1991. Three-dimensional structures of acidic and basic fibroblast growth factors. Science 251:90-93.