메뉴 건너뛰기




Volumn 16, Issue 5, 2011, Pages 1811-1823

EGFR tyrosine kinase inhibitors and multidrug resistance: Perspectives

Author keywords

EGFR; L858R; MDR; Review; T790M; TKIs

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; GLYCOPROTEIN P; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE;

EID: 79955001706     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3823     Document Type: Article
Times cited : (15)

References (80)
  • 2
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • S. A. Aaronson: Growth factors and cancer. Science 254, 1146-1153 (1991) (Pubitemid 21917439)
    • (1991) Science , vol.254 , Issue.5035 , pp. 1146-1153
    • Aaronson, S.A.1
  • 3
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • DOI 10.1038/nrc1609
    • N. E. Hynes and H. A. Lane: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5, 341-354 (2005) (Pubitemid 40637826)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 5
    • 33749018813 scopus 로고    scopus 로고
    • Clinical implications of the mechanism of epidermal growth factor receptor inhibitors
    • J. Marshall: Clinical implications of the mechanism of epidermal growth factor receptor inhibitors. Cancer 107, 1207-1278 (2006)
    • (2006) Cancer , vol.107 , pp. 1207-1278
    • Marshall, J.1
  • 6
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: A model for targeted therapy
    • DOI 10.1158/1078-0432.CCR-05-1554
    • M. Scaltriti and J. Baselga: The epidermal growth factor receptor pathway: a model for targeted therapy. Clin. Cancer. Res. 12, 5268-5272 (2006) (Pubitemid 44497237)
    • (2006) Clinical Cancer Research , vol.12 , Issue.18 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 8
    • 33847273041 scopus 로고    scopus 로고
    • EGFR targeting therapies: Monoclonal antibodies versus tyrosine kinase inhibitors. Similarities and differences
    • DOI 10.1016/j.critrevonc.2006.12.008, PII S1040842807000133
    • O. Dassonville, A. Bozec, J. L. Fischel and G. Milano: EGFR targeting therapies: monoclonal antibodies versus Tyrosine Kinase inhibitors: similarities and differences. Crit. Rev. Oncol. Hematol. 62, 53-61 (2007) (Pubitemid 46330798)
    • (2007) Critical Reviews in Oncology/Hematology , vol.62 , Issue.1 , pp. 53-61
    • Dassonville, O.1    Bozec, A.2    Fischel, J.L.3    Milano, G.4
  • 9
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • P.G. Adams and M.W. Louis: Monoclonal antibody therapy of cancer. Nat. Biotechnol. 23, 1147-57 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1147-1157
    • Adams, P.G.1    Louis, M.W.2
  • 10
    • 31544433743 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in cancer treatment
    • F. Ciardiello: Epidermal growth factor receptor inhibitors in cancer treatment. Future Oncol. 1, 221-234 (2005)
    • (2005) Future Oncol. , vol.1 , pp. 221-234
    • Ciardiello, F.1
  • 12
    • 13944264431 scopus 로고    scopus 로고
    • Gefitinib ('Iressa'): A new therapy for advanced non-small-cell lung cancer
    • DOI 10.1016/j.rmed.2004.08.009, PII S0954611104003087
    • M. Reck and U. Gatzemeier: Gefitinib ("Iressa"): a new therapy for advanced non-small-cell lung cancer. Respir. Med. 99, 298-307 (2005) (Pubitemid 40267946)
    • (2005) Respiratory Medicine , vol.99 , Issue.3 , pp. 298-307
    • Reck, M.1    Gatzemeier, U.2
  • 13
    • 0038343121 scopus 로고    scopus 로고
    • Erlotinib (Tarceva): An update on the clinical trial program
    • R. S. Herbst: Erlotinib. (Tarceva): an update on the clinical trial program. Semin. Oncol. 30, 34-46 (2003) (Pubitemid 36828626)
    • (2003) Seminars in Oncology , vol.30 , Issue.3 SUPPL. 7 , pp. 34-46
    • Herbst, R.S.1
  • 14
    • 1642321097 scopus 로고    scopus 로고
    • Evaluating antiangiogenesis agents in the clinic: The eastern cooperative oncology group portfolio of clinical trials
    • DOI 10.1158/1078-0432.CCR-03-0238
    • J. A. Sparano, R. Gray, B. Giantonio, P. O'Dwyer and R. L. Comis: The Eastern Cooperative Oncology Group Portfolio of Clinical Trials. Evaluating antiangiogenesis agents in the clinic. Clin. Cancer Res. 10, 1206-11 (2004) (Pubitemid 38365208)
    • (2004) Clinical Cancer Research , vol.10 , Issue.4 , pp. 1206-1211
    • Sparano, J.A.1    Gray, R.2    Giantonio, B.3    O'Dwyer, P.4    Comis, R.L.5
  • 15
    • 26444519872 scopus 로고    scopus 로고
    • Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva∞) and Gefitinib (Iressa∞)
    • DOI 10.1634/theoncologist.10-8-579
    • W. S. Siegel-Lakhai, J. H. Beijnen and J. H. Schellens: Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa). Oncologist 10, 579-89 (2005) (Pubitemid 41429121)
    • (2005) Oncologist , vol.10 , Issue.8 , pp. 579-589
    • Siegel-Lakhai, W.S.1    Beijnen, J.H.2    Schellens, J.H.M.3
  • 16
    • 0035884231 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
    • C. L. Arteaga: The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J. Clin. Oncol. 19, 32S-40S (2001) (Pubitemid 32880077)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.18 SUPPL.
    • Arteaga, C.L.1
  • 17
    • 0043210670 scopus 로고    scopus 로고
    • FDA drug approval summary: Gefitinib (ZD1839) (Iressa∞) tablets
    • DOI 10.1634/theoncologist.8-4-303
    • M. H. Cohen, G. A. Williams, Sridhara, G. Chen and R. Pazdur: FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. Oncologist 8, 303-306 (2003) (Pubitemid 36929716)
    • (2003) Oncologist , vol.8 , Issue.4 , pp. 303-306
    • Cohen, M.H.1    Williams, G.A.2    Sridhara, R.3    Chen, G.4    Pazdur, R.5
  • 18
    • 24644458654 scopus 로고    scopus 로고
    • FDA drug approval summary: Erlotinib (Tarceva∞) tablets
    • DOI 10.1634/theoncologist.10-7-461
    • M. H. Cohen, J. R. Johnson, Y. F. Chen, R. Sridhara and R. Pazdur: FDA drug approval summary: erlotinib (Tarceva) tablets. Oncologist 10, 461-466 (2005) (Pubitemid 41266326)
    • (2005) Oncologist , vol.10 , Issue.7 , pp. 461-466
    • Cohen, M.H.1    Johnson, J.R.2    Chen, Y.-F.3    Sridhara, R.4    Pazdur, R.5
  • 19
    • 74549210351 scopus 로고    scopus 로고
    • Lapatinib: A smallmolecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer
    • A. J. Tevaarwerk and J. M. Kolesar: Lapatinib: a smallmolecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer. Clin. Ther.31 Pt 2:2332-48. (2009)
    • (2009) Clin. Ther.31 Pt , vol.2 , pp. 2332-2348
    • Tevaarwerk, A.J.1    Kolesar, J.M.2
  • 20
    • 33745835398 scopus 로고    scopus 로고
    • Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    • DOI 10.1152/physrev.00035.2005
    • R. G. Deeley, C. Westlake and S. P. Cole: Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol. Rev. 86, 849-99 (2006) (Pubitemid 44033384)
    • (2006) Physiological Reviews , vol.86 , Issue.3 , pp. 849-899
    • Deeley, R.G.1    Westlake, C.2    Cole, S.P.C.3
  • 21
    • 63149108552 scopus 로고    scopus 로고
    • Mutations and response to Epidermal Growth Factor Receptor inhibitors
    • P. Laurent-Puig, A. Lievre and H. Blons: Mutations and response to Epidermal Growth Factor Receptor inhibitors. Clinical Cancer Res. 15: 1133-1139 (2009)
    • (2009) Clinical Cancer Res. , vol.15 , pp. 1133-1139
    • Laurent-Puig, P.1    Lievre, A.2    Blons, H.3
  • 22
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • M. M. Gottesman, T. Fojo and S. E. Bates: Multidrug resistance in cancer: role of ATPdependent transporters. Nat. Rev. Cancer 2, 48-58 (2002) (Pubitemid 37328807)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 23
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • DOI 10.1101/gr.GR-1649R
    • M. Dean, A. Rzhetsky and R. Allikmets: The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11, 1156-1166 (2001) (Pubitemid 32677289)
    • (2001) Genome Research , vol.11 , Issue.7 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 24
    • 0026621245 scopus 로고
    • ABC Transporters: From microorganisms to man
    • C. F. Higgins: ABC transporters: from microorganisms to man. Ann. Rev. Cell Biol. 8, 67-113 (1992) (Pubitemid 23000992)
    • (1992) Annual Review of Cell Biology , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 26
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • S. P. Cole, K. E. Sparks, K. Fraser, D. W. Loe, C. E. Grant, G. M. Wilson and R. G. Deeley: Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54, 5902-5910 (1994) (Pubitemid 24375226)
    • (1994) Cancer Research , vol.54 , Issue.22 , pp. 5902-5910
    • Cole, S.P.C.1    Sparks, K.E.2    Fraser, K.3    Loe, D.W.4    Grant, C.E.5    Wilson, G.M.6    Deeley, R.G.7
  • 27
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • DOI 10.1016/S0169-409X(02)00169-2, PII S0169409X02001692
    • A. H. Schinkel and J. W. Jonker. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv. Drug Deliv. Rev. 55, 3-29 (2003) (Pubitemid 36078452)
    • (2003) Advanced Drug Delivery Reviews , vol.55 , Issue.1 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 28
    • 7244232706 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
    • DOI 10.1182/blood-2004-04-1398
    • H. Burger, H. van Tol, A. W. Boersma, M. Brok, E. A. Wiemer, G. Stoter, K. Nooter. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood 104, 2940-2942 (2004) (Pubitemid 39434984)
    • (2004) Blood , vol.104 , Issue.9 , pp. 2940-2942
    • Burger, H.1    Van Tol, H.2    Boersma, A.W.M.3    Brok, M.4    Wiemer, E.A.C.5    Stoter, G.6    Nooter, K.7
  • 31
    • 36348967305 scopus 로고    scopus 로고
    • Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
    • DOI 10.1158/0008-5472.CAN-07-2686
    • Z. Shi, X. X. Peng, I. W. Kim, S. Shukla, Q. S. Si, R. W. Robey, S. E. Bates, T. Shen, C. R. Jr Ashby, L. W. Fu, S. V. Ambudkar and Z. S. Chen: Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATPbinding cassette subfamily G member 2-mediated drug resistance. Cancer Res. 67, 11012-11020 (2007) (Pubitemid 350145931)
    • (2007) Cancer Research , vol.67 , Issue.22 , pp. 11012-11020
    • Shi, Z.1    Peng, X.-X.2    Kim, I.-W.3    Shukla, S.4    Si, Q.-S.5    Robey, R.W.6    Bates, S.E.7    Shen, T.8    Ashby Jr., C.R.9    Fu, L.-W.10    Ambudkar, S.V.11    Chen, Z.-S.12
  • 34
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • W. Pao, V. A. Miller, K. A. Politi, G. J. Riely, R. Somwar, M. F. Zakowski, M. G. Kris and H. Varmus: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2:e73. (2005)
    • (2005) PLoS Med. , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 36
    • 33947287270 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib
    • DOI 10.1158/0008-5472.CAN-06-4293
    • R. Mulloy, A. Ferrand, Y. Kim, R. Sordella, D. W. Bell, D. A. Haber, K. S. Anderson and J. Settleman: Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. Cancer Res. 67, 2325-2330 (2007) (Pubitemid 46424253)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 2325-2330
    • Mulloy, R.1    Ferrand, A.2    Kim, Y.3    Sordella, R.4    Bell, D.W.5    Haber, D.A.6    Anderson, K.S.7    Settleman, J.8
  • 38
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • I. B. Weinstein and A. Joe: Oncogene addiction. Cancer Res. 68, 3077-3080 (2008)
    • (2008) Cancer Res. , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 39
    • 4644274700 scopus 로고    scopus 로고
    • Mutations and addiction to EGFR: The Achilles 'heal' of lung cancers?
    • DOI 10.1016/j.molmed.2004.08.008, PII S1471491404002163
    • A. F. Gazdar, H. Shigematsu, J. Herz and J. D. Minna: Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers? Trends Mol. Med. 10, 481-486 (2004) (Pubitemid 39303620)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.10 , pp. 481-486
    • Gazdar, A.F.1    Shigematsu, H.2    Herz, J.3    Minna, J.D.4
  • 42
    • 61549108338 scopus 로고    scopus 로고
    • EGFR T790M mutation a double role in lung cancer cell serviva?
    • K. Suda, R. Onozato, Y. Yatabe andT. Mitsudomi: EGFR T790M mutation a double role in lung cancer cell serviva? J. Thoracic Onc. 4, 1-4 (2009)
    • (2009) J. Thoracic Onc. , vol.4 , pp. 1-4
    • Suda, K.1    Onozato, R.2    Yatabe, Y.3    Mitsudomi, T.4
  • 44
    • 77949371041 scopus 로고    scopus 로고
    • Perspectives of Pglycoprotein modulating agents in oncology and neurodegenerative diseases: Pharmaceutical, biological and diagnostic potentials
    • N. A. Colabufo, F. Berardi, M. Cantore, M. Contino, C. Inglese, M. Niso and R. Perrone: Perspectives of Pglycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials. J. Med. Chem. 53, 1883-1897 (2010)
    • (2010) J. Med. Chem. , vol.53 , pp. 1883-1897
    • Colabufo, N.A.1    Berardi, F.2    Cantore, M.3    Contino, M.4    Inglese, C.5    Niso, M.6    Perrone, R.7
  • 45
    • 65049084126 scopus 로고    scopus 로고
    • Overcoming multidrug resistance: Alternative approaches to p-glycoprotein modulators
    • Colabufo, N. A., Ed.; Research Signpost: Kerala (India)
    • S. Nobili and E. Mini Overcoming Multidrug Resistance: Alternative approaches to P-glycoprotein modulators. In Multidrug Resistance : Biological and Pharmaceutical Advance in the Antitumour Treatment; Colabufo, N. A., Ed.; Research Signpost: Kerala (India), pp 101-139 (2008)
    • (2008) Multidrug Resistance : Biological and Pharmaceutical Advance in the Antitumour Treatment , pp. 101-139
    • Nobili, S.1    Mini, E.2
  • 46
    • 0003351312 scopus 로고    scopus 로고
    • The extracellular environment and cancer
    • Tannock, I.F.; Hill Rp (eds), 3rd Edition, McGraw-Hill, New York
    • S. Dedhar, G. E. Hannigan, J. Rak and R. S. Kerbel. The extracellular environment and cancer. In: Tannock, I.F.; Hill Rp (eds) The Basic Science of Oncology, 3rd Edition, McGraw-Hill, New York, pp 198-218 (1998)
    • (1998) The Basic Science of Oncology , pp. 198-218
    • Dedhar, S.1    Hannigan, G.E.2    Rak, J.3    Kerbel, R.S.4
  • 47
    • 0035694858 scopus 로고    scopus 로고
    • The role for liposomal drug delivery in molecular and pharmacological strategies to overcome multidrug resistance
    • DOI 10.1023/A:1013108524062
    • L. D. Mayer and J. A. Shabbits: The role for liposomal drug delivery in molecular and pharmacological strategies to overcome multidrug resistance. Cancer Metastasis Rev. 20, 87-93 (2001) (Pubitemid 34074683)
    • (2001) Cancer and Metastasis Reviews , vol.20 , Issue.1-2 , pp. 87-93
    • Mayer, L.D.1    Shabbits, J.A.2
  • 49
    • 73349097214 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib and second-generation tyrosine inhibitors in chronic myeloid leukemia
    • D. Milojkovic and J. Apperley: Mechanisms of Resistance to Imatinib and Second-Generation Tyrosine Inhibitors in Chronic Myeloid Leukemia. Clin. Cancer Res. 15, 7519-7527 (2009)
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7519-7527
    • Milojkovic, D.1    Apperley, J.2
  • 60
    • 44849125728 scopus 로고    scopus 로고
    • Derivatives of Iressa, a specific epidermal growth factor receptor inhibitor, are powerful apoptosis inducers in PC3 prostatic cancer cells
    • A. Telliez, M. Desroses, N. Pommery, O. Briand, A. Farce, G. Laconde, A. Lemoine, P. Depreux and J. P. Henichart: Derivatives of Iressa, a specific epidermal growth factor receptor inhibitor, are powerful apoptosis inducers in PC3 prostatic cancer cells. ChemMedChem, 2, 318-332 (2007)
    • (2007) ChemMedChem , vol.2 , pp. 318-332
    • Telliez, A.1    Desroses, M.2    Pommery, N.3    Briand, O.4    Farce, A.5    Laconde, G.6    Lemoine, A.7    Depreux, P.8    Henichart, J.P.9
  • 62
    • 77953325590 scopus 로고    scopus 로고
    • Design and synthesis of novel Gefitinib analogues with improved anti-tumor activity
    • X. Wu, M. Li, Y. Qu, W. Tang, Y. Zheng, J. Lian, M. Ji and L. Xu: Design and synthesis of novel Gefitinib analogues with improved anti-tumor activity. Bioorg. Med. Chem. 18, 3812-22 (2010)
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 3812-3822
    • Wu, X.1    Li, M.2    Qu, Y.3    Tang, W.4    Zheng, Y.5    Lian, J.6    Ji, M.7    Xu, L.8
  • 66
    • 1842532997 scopus 로고    scopus 로고
    • VX-710 (Biricodar) Increases Drug Retention and Enhances Chemosensitivity in Resistant Cells Overexpressing P-Glycoprotein, Multidrug Resistance Protein, and Breast Cancer Resistance Protein
    • DOI 10.1158/1078-0432.CCR-0914-3
    • H. Minderman, K. L. O'Loughlin, L. Pendyala, M. R. Baer: VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Clin. Cancer Res. 10, 1826-1834 (2004) (Pubitemid 38435574)
    • (2004) Clinical Cancer Research , vol.10 , Issue.5 , pp. 1826-1834
    • Minderman, H.1    O'Loughlin, K.L.2    Pendyala, L.3    Baer, M.R.4
  • 71
    • 0242331085 scopus 로고    scopus 로고
    • Multidrug resistance reversal agents
    • J. Robert and C Jarry: Multidrug resistance reversal agents. J. Med. Chem. 46, 4805-4817 (2003) (Pubitemid 37352018)
    • (2003) Journal of Medicinal Chemistry , vol.46 , Issue.23 , pp. 4805-4817
    • Robert, J.1    Jarry, C.2
  • 72
    • 0037457796 scopus 로고    scopus 로고
    • Considerations in the design and development of transport inhibitors as adjuncts to drug therapy
    • DOI 10.1016/S0169-409X(02)00175-8, PII S0169409X02001758
    • A. H. Dantzig, D. P. de Alwisa and M. Burgess: Considerations in the design and development of transport inhibitors as adjuncts to drug therapy. Adv. Drug Deliv. Rev. 55, 133-150 (2003) (Pubitemid 36078455)
    • (2003) Advanced Drug Delivery Reviews , vol.55 , Issue.1 , pp. 133-150
    • Dantzig, A.H.1    De Alwis, D.P.2    Burgess, M.3
  • 73
    • 33745748312 scopus 로고    scopus 로고
    • The functions and structure of ABC transporters: Implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR)
    • E. Teodori, S. Dei, C. Martelli, S. Scapecchi and F. Gualtieri: The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR). Curr. Drug Targets 7, 893-909 (2006)
    • (2006) Curr. Drug Targets , vol.7 , pp. 893-909
    • Teodori, E.1    Dei, S.2    Martelli, C.3    Scapecchi, S.4    Gualtieri, F.5
  • 74
    • 33846077187 scopus 로고    scopus 로고
    • A search for multidrug resistance modulators: The effects of retinoids in human colon carcinoma cells
    • G. Bartolini, M. Orlandi, A. Papi, K. Ammar, F. Guerra, A. M. Ferreri and P. Rocchi: A search for multidrug resistance modulators: the effects of retinoids in human colon carcinoma cells. In vivo 20, 729-733 (2006)
    • (2006) Vivo , vol.20 , pp. 729-733
    • Bartolini, G.1    Orlandi, M.2    Papi, A.3    Ammar, K.4    Guerra, F.5    Ferreri, A.M.6    Rocchi, P.7
  • 75
    • 43349088564 scopus 로고    scopus 로고
    • Constitutive overexpression of p-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells
    • DOI 10.1007/s11095-007-9376-3
    • C. Hirayama, H. Watanabe, R. Nakashima, T. Nanbu, A. Hamada, A. Kuniyasu, H. Nakayama, T. Kawaguchi and H. Saito: Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinibresistance in K562 cells. Pharm. Res. 25, 827-835 (2008) (Pubitemid 351661829)
    • (2008) Pharmaceutical Research , vol.25 , Issue.4 , pp. 827-835
    • Hirayama, C.1    Watanabe, H.2    Nakashima, R.3    Nanbu, T.4    Hamada, A.5    Kuniyasu, A.6    Nakayama, H.7    Kawaguchi, T.8    Saito, H.9
  • 76
    • 33747855481 scopus 로고    scopus 로고
    • Comparingantibodyand smallmolecule therapies for cancer
    • K. Imai and A. Takaoka: Comparingantibodyand smallmolecule therapies for cancer. Nat. Rev. Cancer 6, 714-727 (2006)
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 78
    • 68349126964 scopus 로고    scopus 로고
    • Novel tyrosine kinase inhibitors in the treatment of cancer
    • A. Ocana, R. Serrano, R. Calero and A. Pandiella: Novel tyrosine kinase inhibitors in the treatment of cancer. Curr Drug Targets 10, 575-576 (2009)
    • (2009) Curr Drug Targets , vol.10 , pp. 575-576
    • Ocana, A.1    Serrano, R.2    Calero, R.3    Pandiella, A.4
  • 79
    • 19744364796 scopus 로고    scopus 로고
    • Biochemistry: Structural bioinformatics-based design of selective, irreversible kinase inhibitors
    • DOI 10.1126/science1108367
    • M. S. Cohen, C. Zhang, K. M. Shokat and J. Taunton: Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 308, 1318-1321 (2005) (Pubitemid 40746129)
    • (2005) Science , vol.308 , Issue.5726 , pp. 1318-1321
    • Cohen, M.S.1    Zhang, C.2    Shokat, K.M.3    Taunton, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.