Role of SLAM in NKT cell development revealed by transgenic complementation in NOD mice

Journal of Immunology

Volumn 186, Issue 7, 2011, Pages 3953-3965

  Jordan, Margaret A ^a   Fletcher, Julie M ^a   Jose, Roby ^a   Chowdhury, Shahead ^a   Gerlach, Nicole ^a   Allison, Janette ^b   Baxter, Alan G ^a  

^a JAMES COOK UNIVERSITY   (Australia)

^b Vincent's Institute   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD150 ANTIGEN; GENOMIC DNA; INTERLEUKIN 17; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN FUNCTION; ARTICLE; CD4+ CD8+ THYMOCYTE; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; FEMALE; GENE; GENE DOSAGE; GENETIC COMPLEMENTATION; GENETIC VARIABILITY; HCD2 MINIGENE; IMMUNOREGULATION; INSULITIS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTOPOIESIS; MALE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PURIFYING SELECTION; THYMOCYTE; THYMUS; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD2; CELL DIFFERENTIATION; CELLS, CULTURED; GENETIC COMPLEMENTATION TEST; HUMANS; MICE; MICE, 129 STRAIN; MICE, INBRED A; MICE, INBRED AKR; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, TRANSGENIC; NATURAL KILLER T-CELLS; PROMOTER REGIONS, GENETIC; THYMUS GLAND;

EID: 79954999880     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003305     Document Type: Article

References (82)

1. Godfrey, D. I., K. J. Hammond, L. D. Poulton, M. J. Smyth, and A. G. Baxter. 2000. NKT cells: Facts, functions and fallacies. Immunol. Today 21: 573-583.
2. Godfrey, D. I., and M. Kronenberg. 2004. Going both ways: Immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 114: 1379-1388. (Pubitemid 40385565)
3. Dellabona, P., E. Padovan, G. Casorati, M. Brockhaus, and A. Lanzavecchia. 1994. An invariant V α 24-J α Q/V β 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J. Exp. Med. 180: 1171-1176.
4. Lantz, O., and A. Bendelac. 1994. An invariant T cell receptor a chain is used by a unique subset of major histocompatibility complex I-specific CD4+ and CD4- 8- T cells in mice and humans. J. Exp. Med. 180: 1097-1106. (Pubitemid 24256622)
5. Porcelli, S., C. E. Yockey, M. B. Brenner, and S. P. Balk. 1993. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/ beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J. Exp. Med. 178: 1-16. (Pubitemid 23173239)
6. Bendelac, A. 1995. Mouse NK1+ T cells. Curr. Opin. Immunol. 7: 367-374.
7. Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2: 557-568. (Pubitemid 37328731)
8. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted and TCRmediated activation of valpha14 NKT cells by glycosylceramides. Science 278: 1626-1629. (Pubitemid 27516282)
9. Burdin, N., L. Brossay, Y. Koezuka, S. T. Smiley, M. J. Grusby, M. Gui, M. Taniguchi, K. Hayakawa, and M. Kronenberg. 1998. Selective ability of mouse CD1 to present glycolipids: α-galactosylceramide specifically stimulates V α 14+ NK T lymphocytes. J. Immunol. 161: 3271-3281.
10. Joyce, S., A. S. Woods, J. W. Yewdell, J. R. Bennink, A. D. De Silva, A. Boesteanu, S. P. Balk, R. J. Cotter, and R. R. Brutkiewicz. 1998. Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol. Science 279: 1541-1544. (Pubitemid 28217078)
11. Zhou, D., J. Mattner, C. Cantu, III, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y. P. Wu, T. Yamashita, et al. 2004. Lysosomal glycosphingolipid recognition by NKT cells. Science 306: 1786-1789. (Pubitemid 39601398)
12. Kobayashi, E., K. Motoki, T. Uchida, H. Fukushima, and Y. Koezuka. 1995. KRN7000, a novel immunomodulator, and its antitumor activities. Oncol. Res. 7: 529-534. (Pubitemid 26077987)
13. Matsuda, J. L., O. V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C. R. Wang, Y. Koezuka, and M. Kronenberg. 2000. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192: 741-754.
14. Benlagha, K., A. Weiss, A. Beavis, L. Teyton, and A. Bendelac. 2000. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J. Exp. Med. 191: 1895-1903. (Pubitemid 30390352)
15. Coquet, J. M., S. Chakravarti, K. Kyparissoudis, F. W. McNab, L. A. Pitt, B. S. McKenzie, S. P. Berzins, M. J. Smyth, and D. I. Godfrey. 2008. Diverse cytokine production by NKT cell subsets and identification of an IL-17- producing CD42NK1.12 NKT cell population. Proc. Natl. Acad. Sci. USA 105: 11287-11292.
16. Godfrey, D. I., S. Stankovic, and A. G. Baxter. 2010. Raising the NKT cell family. Nat. Immunol. 11: 197-206.
17. Pellicci, D. G., K. J. Hammond, A. P. Uldrich, A. G. Baxter, M. J. Smyth, and D. I. Godfrey. 2002. A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J. Exp. Med. 195: 835-844. (Pubitemid 34286755)
18. Benlagha, K., D. G. Wei, J. Veiga, L. Teyton, and A. Bendelac. 2005. Characterization of the early stages of thymic NKT cell development. J. Exp. Med. 202: 485-492. (Pubitemid 41186947)
19. Gadue, P., and P. L. Stein. 2002. NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J. Immunol. 169: 2397-2406. (Pubitemid 34920982)
20. Pellicci, D. G., A. P. Uldrich, K. Kyparissoudis, N. Y. Crowe, A. G. Brooks, K. J. L. Hammond, S. Sidobre, M. Kronenberg, M. J. Smyth, and D. I. Godfrey. 2003. Intrathymic NKT cell development is blocked by the presence of α-galactosylceramide. Eur. J. Immunol. 33: 1816-1823. (Pubitemid 37120852)
21. Gadue, P., N. Morton, and P. L. Stein. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J. Exp. Med. 190: 1189-1196.
22. Eberl, G., B. Lowin-Kropf, and H. R. MacDonald. 1999. Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J. Immunol. 163: 4091-4094. (Pubitemid 29474468)
23. Nichols, K. E., J. Hom, S. Y. Gong, A. Ganguly, C. S. Ma, J. L. Cannons, S. G. Tangye, P. L. Schwartzberg, G. A. Koretzky, and P. L. Stein. 2005. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat. Med. 11: 340-345. (Pubitemid 40460564)
24. Pasquier, B., L. Yin, M. C. Fondanèche, F. Relouzat, C. Bloch-Queyrat, N. Lambert, A. Fischer, G. de Saint-Basile, and S. Latour. 2005. Defective NKT cell development in mice and humans lacking the adapter SAP, the Xlinked lymphoproliferative syndrome gene product. J. Exp. Med. 201: 695-701. (Pubitemid 40395115)
25. Chung, B., A. Aoukaty, J. Dutz, C. Terhorst, and R. Tan. 2005. Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J. Immunol. 174: 3153-3157. (Pubitemid 40354014)
26. Makino, S., K. Kunimoto, Y. Muraoka, Y. Mizushima, K. Katagiri, and Y. Tochino. 1980. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 29: 1-13. (Pubitemid 10185796)
27. Robinson, C. P., S. Yamachika, C. E. Alford, C. Cooper, E. L. Pichardo, N. Shah, A. B. Peck, and M. G. Humphreys-Beher. 1997. Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sjögren syndrome. Proc. Natl. Acad. Sci. USA 94: 5767-5771.
28. Baxter, A. G., and T. E. Mandel. 1991. Hemolytic anemia in non-obese diabetic mice. Eur. J. Immunol. 21: 2051-2055.
29. Baxter, A. G., D. Healey, and A. Cooke. 1994. Mycobacteria precipitate autoimmune rheumatic disease in NOD mice via an adjuvant-like activity. Scand. J. Immunol. 39: 602-606. (Pubitemid 24217154)
30. Esteban, L. M., T. Tsoutsman, M. A. Jordan, D. Roach, L. D. Poulton, A. Brooks, O. V. Naidenko, S. Sidobre, D. I. Godfrey, and A. G. Baxter. 2003. Genetic control of NKT cell numbers maps to major diabetes and lupus loci. J. Immunol. 171: 2873-2878. (Pubitemid 37093507)
31. Baker, D., O. A. Rosenwasser, J. K. O'Neill, and J. L. Turk. 1995. Genetic analysis of experimental allergic encephalomyelitis in mice. J. Immunol. 155: 4046-4051.
32. Poulton, L. D., M. J. Smyth, C. G. Hawke, P. Silveira, D. Shepherd, O. V. Naidenko, D. I. Godfrey, and A. G. Baxter. 2001. Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int. Immunol. 13: 887-896. (Pubitemid 32685201)
33. Hammond, K. J. L., D. G. Pellicci, L. D. Poulton, O. V. Naidenko, A. A. Scalzo, A. G. Baxter, and D. I. Godfrey. 2001. CD1d-restricted NKT cells: An interstrain comparison. J. Immunol. 167: 1164-1173. (Pubitemid 32703109)
34. Baxter, A. G., S. J. Kinder, K. J. Hammond, R. Scollay, and D. I. Godfrey. 1997. Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46: 572-582. (Pubitemid 27143372)
35. Chen, Y. G., J. P. Driver, P. A. Silveira, and D. V. Serreze. 2007. Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. Immunogenetics 59: 705-712. (Pubitemid 47415563)
36. Fletcher, J. M., M. A. Jordan, S. L. Snelgrove, R. M. Slattery, F. D. Dufour, K. Kyparissoudis, G. S. Besra, D. I. Godfrey, and A. G. Baxter. 2008. Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4. J. Immunol. 181: 3400-3412.
37. Zekavat, G., R. Mozaffari, V. J. Arias, S. Y. Rostami, A. Badkerhanian, A. J. Tenner, K. E. Nichols, A. Naji, and H. Noorchashm. 2010. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state. Immunogenetics 62: 397-407.
38. Rocha-Campos, A. C., R. Melki, R. Zhu, N. Deruytter, D. Damotte, M. Dy, A. Herbelin, and H. J. Garchon. 2006. Genetic and functional analysis of the Nkt1 locus using congenic NOD mice: Improved Valpha14-NKT cell performance but failure to protect against type 1 diabetes. Diabetes 55: 1163-1170. (Pubitemid 44100196)
39. Jordan, M. A., J. M. Fletcher, D. Pellicci, and A. G. Baxter. 2007. Slamf1, the NKT cell control gene Nkt1. J. Immunol. 178: 1618-1627. (Pubitemid 46154633)
40. Nichols, K. E., C. S. Ma, J. L. Cannons, P. L. Schwartzberg, and S. G. Tangye. 2005. Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol. Rev. 203: 180-199. (Pubitemid 40179702)
41. Dietrich, W. F., J. Miller, R. Steen, M. A. Merchant, D. Damron-Boles, Z. Husain, R. Dredge, M. J. Daly, K. A. Ingalls, and T. J. O'Connor. 1996. A comprehensive genetic map of the mouse genome. [Published erratum appears in 1996 Nature 381: 172.] Nature 380: 149-152 (Pubitemid 26085877)
42. Zhumabekov, T., P. Corbella, M. Tolaini, and D. Kioussis. 1995. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods 185: 133-140.
43. Wandstrat, A. E., C. Nguyen, N. Limaye, A. Y. Chan, S. Subramanian, X. H. Tian, Y. S. Yim, A. Pertsemlidis, H. R. Garner, Jr., L. Morel, and E. K. Wakeland. 2004. Association of extensive polymorphisms in the SLAM/ CD2 gene cluster with murine lupus. Immunity 21: 769-780. (Pubitemid 39626668)
44. Baev, D. V., S. Caielli, F. Ronchi, M. Coccia, F. Facciotti, K. E. Nichols, and M. Falcone. 2008. Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and DC affects differentiation of IL-4/IL-10-secreting NKT2 cells in NOD mice. J. Immunol. 181: 869-877.
45. Hammond, K. J., L. D. Poulton, L. J. Palmisano, P. A. Silveira, D. I. Godfrey, and A. G. Baxter. 1998. ab-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187: 1047-1056. (Pubitemid 28176405)
46. Laloux, V., L. Beaudoin, D. Jeske, C. Carnaud, and A. Lehuen. 2001. NK T cellinduced protection against diabetes in V alpha 14-J alpha 281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen. J. Immunol. 166: 3749-3756. (Pubitemid 32224898)
47. Ueno, A., J. Wang, L. Cheng, J. S. Im, Y. Shi, S. A. Porcelli, and Y. Yang. 2008. Enhanced early expansion and maturation of semi-invariant NK T cells inhibited autoimmune pathogenesis in congenic nonobese diabetic mice. J. Immunol. 181: 6789-6796.
48. Lehuen, A., O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J. F. Bach, and R. C. Monteiro. 1998. Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188: 1831-1839. (Pubitemid 28536770)
49. Falcone, M., F. Facciotti, N. Ghidoli, P. Monti, S. Olivieri, L. Zaccagnino, E. Bonifacio, G. Casorati, F. Sanvito, and N. Sarvetnick. 2004. Up-regulation of CD1d expression restores the immunoregulatory function of NKT cells and prevents autoimmune diabetes in nonobese diabetic mice. J. Immunol. 172: 5908-5916. (Pubitemid 38621189)
50. Hong, S., M. T. Wilson, I. Serizawa, L. Wu, N. Singh, O. V. Naidenko, T. Miura, T. Haba, D. C. Scherer, J. Wei, et al. 2001. The natural killer T-cell ligand a-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7: 1052-1056. (Pubitemid 32937387)
51. Sharif, S., G. A. Arreaza, P. Zucker, Q. S. Mi, J. Sondhi, O. V. Naidenko, M. Kronenberg, Y. Koezuka, T. L. Delovitch, J. M. Gombert, et al. 2001. Activation of natural killer T cells by a-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes. Nat. Med. 7: 1057-1062. (Pubitemid 32937388)
52. Wang, B., Y. B. Geng, and C. R. Wang. 2001. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194: 313-320.
53. Naumov, Y. N., K. S. Bahjat, R. Gausling, R. Abraham, M. A. Exley, Y. Koezuka, S. B. Balk, J. L. Strominger, M. Clare-Salzer, and S. B. Wilson. 2001. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating DC subsets. Proc. Natl. Acad. Sci USA 98: 13838-13843. (Pubitemid 33115985)
54. Shi, F. D., M., B. Flodström, S. H. Balasa, K. Kim, J. L. Van Gunst, S. B. Strominger, Wilson, and N. Sarvetnick. 2001. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc. Natl. Acad. Sci USA 98: 6777-6782. (Pubitemid 32538293)
55. Mars, L. T., V. Laloux, K. Goude, S. Desbois, A. Saoudi, L. Van Kaer, H. Lassmann, A. Herbelin, A. Lehuen, and R. S. Liblau. 2002. Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J. Immunol. 168: 6007-6011. (Pubitemid 34620014)
56. Fritz, R. B., and M. L. Zhao. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, α β+ T cells. J. Immunol. 166: 4209-4215. (Pubitemid 32224955)
57. Singh, A. K., M. T. Wilson, S. Hong, D. Olivares-Villagómez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer. 2001. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 194: 1801-1811. (Pubitemid 34028659)
58. Jahng, A. W., I. Maricic, B. Pedersen, N. Burdin, O. Naidenko, M. Kronenberg, Y. Koezuka, and V. Kumar. 2001. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J. Exp. Med. 194: 1789-1799. (Pubitemid 34028658)
59. Miyamoto, K., S. Miyake, and T. Yamamura. 2001. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413: 531-534. (Pubitemid 32938752)
60. Furlan, R., A. Bergami, D. Cantarella, E. Brambilla, M. Taniguchi, P. Dellabona, G. Casorati, and G. Martino. 2003. Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: Critical roles for administration route and IFN-γ. Eur. J. Immunol. 33: 1830-1838. (Pubitemid 37120854)
61. Teige, A., I. Teige, S. Lavasani, R. Bockermann, E. Mondoc, R. Holmdahl, and S. Issazadeh-Navikas. 2004. CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis. J. Immunol. 172: 186-194. (Pubitemid 38020471)
62. Wilson, S. B., S. C. Kent, K. T. Patton, T. Orban, R. A. Jackson, M. Exley, S. Porcelli, D. A. Schatz, M. A. Atkinson, S. P. Balk, et al. 1998. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 391: 177-181. (Pubitemid 28092476)
63. Wilson, S. B., S. C. Kent, H. F. Horton, A. A. Hill, P.l L. Bollyky, D. A. Hafler, J. L. Strominger, and M. C. Byrne. 2000. Multiple differences in gene expression in regulatory Vα 24Jα Q T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci USA 97: 7411-7416. (Pubitemid 30431477)
64. Kukreja, A., G. Cost, J. Marker, C. Zhang, Z. Sun, K. Lin-Su, S. Ten, M. Sanz, M. Exley, B. Wilson, et al. 2002. Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Invest. 109: 131-140. (Pubitemid 34052549)
65. Kis, J., P. Engelmann, K. Farkas, G. Richman, S. Eck, J. Lolley, H. Jalahej, M. Borowiec, S. C. Kent, A. Treszl, and T. Orban. 2007. Reduced CD4+ subset and Th1 bias of the human iNKT cells in type 1 diabetes mellitus. J. Leukoc. Biol. 81: 654-662. (Pubitemid 46393543)
66. Poulton, L. D., and A. G. Baxter. 2001. Clinical application of NKT cell assays to the prediction of type 1 diabetes. Diabetes Metab. Res. Rev. 17: 429-435. (Pubitemid 34030745)
67. Lee, P. T., A. Putnam, K. Benlagha, L. Teyton, P. A. Gottlieb, and A. Bendelac. 2002. Testing the NKT cell hypothesis of human IDDM pathogenesis. J. Clin. Invest. 110: 793-800.
68. Tsutsumi, Y., X. Jie, K. Ihara, A. Nomura, S. Kanemitsu, H. Takada, and T. Hara. 2006. Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with type 1 diabetes. Diabet. Med. 23: 1145-1150. (Pubitemid 44401147)
69. Oling, V., J. Marttila, M. Knip, O. Simell, and J. Ilonen. 2007. Circulating CD4+ CD25 high regulatory T cells and natural killer T cells in children with newly diagnosed type 1 diabetes or with diabetes-associated autoantibodies. Ann. N. Y. Acad. Sci. 1107: 363-372. (Pubitemid 47528813)
70. Roman-Gonzalez, A., M. E. Moreno, J. M. Alfaro, F. Uribe, G. Latorre-Sierra, M. T. Rugeles, and C. J. Montoya. 2009. Frequency and function of circulating invariant NKT cells in autoimmune diabetes mellitus and thyroid diseases in Colombian patients. Hum. Immunol. 70: 262-268.
71. Oikawa, Y., A. Shimada, S. Yamada, Y. Motohashi, Y. Nakagawa, J. Irie, T. Maruyama, and T. Saruta. 2002. High frequency of valpha24(+) vbeta11(+) Tcells observed in type 1 diabetes. Diabetes Care 25: 1818-1823. (Pubitemid 41071093)
72. Oikawa, Y., A. Shimada, S. Yamada, Y. Motohashi, Y. Nakagawa, J. Irie, T. Maruyama, and T. Saruta. 2003. NKT cell frequency in Japanese type 1 diabetes. Ann. N. Y. Acad. Sci. 1005: 230-232. (Pubitemid 38507760)
73. Illés, Z., T. Kondo, J. Newcombe, N. Oka, T. Tabira, and T. Yamamura. 2000. Differential expression of NK T cell Valpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J. Immunol. 164: 4375-4381. (Pubitemid 30215101)
74. Gausling, R., C. Trollmo, and D. A. Hafler. 2001. Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis. Clin. Immunol. 98: 11-17.
75. Araki, M., T. Kondo, J. E. Gumperz, M. B. Brenner, S. Miyake, and T. Yamamura. 2003. Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission. Int. Immunol. 15: 279-288. (Pubitemid 36267120)
76. Démoulins, T., G. Gachelin, D. Bequet, and D. Dormont. 2003. A biased Va24 Tcell repertoire leads to circulating NKT-cell defects in a MS patient at the onset of his disease. Immunol. Lett. 90: 223-228. (Pubitemid 37548481)
77. van der Vliet, H. J., B. M. von Blomberg, N. Nishi, M. Reijm, A. E. Voskuyl, A. A. van Bodegraven, C. H. Polman, T. Rustemeyer, P. Lips, A. J. M. van den Eertwegh, et al. 2001. Circulating V(α24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin. Immunol. 100: 144-148.
78. O'Keeffe, J., C. M. Gately, T. Counihan, M. Hennessy, T. Leahy, A. P. Moran, and E. L. Hogan. 2008. T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to α-galactosylceramide are impaired. J. Neurol. Sci. 275: 22-28.
79. Griewank, K., C. Borowski, S. Rietdijk, N. Wang, A. Julien, D. G. Wei, A. A. Mamchak, C. Terhorst, and A. Bendelac. 2007. Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27: 751-762. (Pubitemid 350102258)
80. Berzins, S. P., A. P. Uldrich, D. G. Pellicci, F. McNab, Y. Hayakawa, M. J. Smyth, and D. I. Godfrey. 2004. Parallels and distinctions between T and NKT cell development in the thymus. Immunol. Cell Biol. 82: 269-275. (Pubitemid 38870021)
81. Mi, Q. S., D. Ly, P. Zucker, M. McGarry, and T. L. Delovitch. 2004. Interleukin- 4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells. Diabetes 53: 1303-1310. (Pubitemid 38569017)
82. Novak, J., L. Beaudoin, T. Griseri, and A. Lehuen. 2005. Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts. J. Immunol. 174: 1954-1961. (Pubitemid 40223936)