Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes

Biochemical and Biophysical Research Communications

Volumn 407, Issue 4, 2011, Pages 818-822

  Lee, Joo Young ^a   Hashizaki, Hikari ^a   Goto, Tsuyoshi ^a   Sakamoto, Tomoya ^a   Takahashi, Nobuyuki ^a   Kawada, Teruo ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Adipocyte; Fatty acid oxidation; Insulin sensitivity; PPAR

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; ACYL COENZYME A OXIDASE; ADIPOCYTE SPECIFIC FATTY ACID BINDING PROTEIN; CARBON DIOXIDE; CARNITINE PALMITOYLTRANSFERASE I; CARNITINE PALMITOYLTRANSFERASE IB; FATTY ACID BINDING PROTEIN; GLUCOSE; INSULIN; LIPID; LIPOPROTEIN LIPASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; ENERGY BALANCE; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; METABOLITE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL;

ADIPOCYTES; ADIPOGENESIS; BUTYRIC ACIDS; CELL LINE; FATTY ACIDS; HUMANS; OXIDATION-REDUCTION; PHENYLUREA COMPOUNDS; PPAR ALPHA;

EID: 79954997163     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.106     Document Type: Article

References (25)

1. Miranda P.J., DeFronzo R.A., Califf R.M., Guyton J.R. Metabolic syndrome: definition, pathophysiology, and mechanisms. Am. Heart J. 2005, 149:33-45.
2. Spiegelman B.M., Flier J.S. Adipogenesis and obesity: rounding out the big picture. Cell 1996, 87:377-389.
3. Takahashi N., Goto T., Hirai S., Uemura T., Kawada T. Genome science of lipid metabolism and obesity. Forum Nutr. 2009, 61:25-38.
4. Rocchi S., Picard F., Vamecq J., et al. A unique PPAR-gamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol. Cell 2001, 8:737-747.
5. Semple R.K., Chatterjee V.K., O'Rahilly S. PPAR-gamma and human metabolic disease. J. Clin. Invest. 2006, 116:581-589.
6. Mandard S., Müllar M., Kersten S. Peroxisome proliferator-activated receptors-alpha target genes. Cell. Mol. Life Sci. 2004, 61:393-416.
7. Tsuchida A., Yamauchi T., Takekawa S., Hada Y., Ito Y., Maki T., Kadowaki T. PPAR-alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPAR-alpha, PPAR-gamma, and their combination. Diabetes 2005, 54:3358-3370.
8. Hiuge A., Tenenbaum A., Maeda N., Benderly M., Kumada M., Fisman E.Z., Tanne D., Matas Z., Hibuse T., Fujita K., Nishizawa H., Adler Y., Motro M., Kihara S., Shimomura I., Behar S., Funahashi T. Effects of PPAR ligands, bezafibrate and fenofibrate, on adiponectin level. Arterioscler. Thromb. Vasc. Biol. 2007, 27:635-641.
9. Vernochet C., Azoulay S., Duval D., Guedj R., Cottrez F., Vidal H., Ailhaud G., Dani C. Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines. J. Biol. Chem. 2005, 280:2238-2243.
10. Rodriguez A.M., Elabd C., Delteil F., Astier J., Vernochet C., Saint-Marc P., Guesnet J., Guezennec A., Amri E.Z., Dani C., Ailhaud G. Adipocyte differentiation of multipotent cells established from human adipose tissue. Biochem. Biophys. Res. Commun. 2004, 315:255-263.
11. Uemura T., Goto T., Kang M.S., Mizoguchi N., Hirai S., Lee J.Y., Nakano Y., Shono J., Hoshino S., Taketani K., Tsuge N., Narukami T., Makishima M., Takahashi N., Kawada T. Diosgenin, the main aglycon of fenugreek, inhibits LXR-alpha activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese, diabetic mice. J. Nutr. 2011, 141:17-23.
12. Takahashi N., Kawada T., Yamamoto T., Goto T., Taimatsu A., Aoki N., Kawasaki H., Taira K., Yokoyama K.K., Kamei Y., Fushiki T. Overexpression and ribozyme-mediated targeting of transcriptional coactivators CBP and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of PPAR-gamma. J. Biol. Chem. 2002, 277:16906-16912.
13. Takahashi N., Kawada T., Goto T., Yamamoto T., Taimatsu A., Matsui N., Kimura K., Saito M., Hosokawa M., Miyashita K., Fushiki T. Dual action of isoprenols from herbal medicines on both PPAR-gamma and PPAR-alpha in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett. 2002, 514:315-322.
14. Goto T., Takahashi N., Kato S., Egawa K., Ebisu S., Moriyama T., Fushiki T., Kawada T. Phytol directly activates PPAR-alpha and regulates gene expression involved in lipid metabolism in PPAR-alpha-expressing HepG2 hepatocytes. Biochem. Biophys. Res. Commun. 2005, 337:440-445.
15. Takahashi N., Goto T., Taimatsu A., Egawa K., Kagoh S., Kusudo T., Sakamoto T., Ohyane C., Lee J.Y., Kim Y.I., Uemura T., Hirai S., Kawada T. Bixin regulates mRNA expression involved in 3T3-L1 adipocytes through PPAR-gamma activation. Biochem. Biophys. Res. Commun. 2009, 390:1372-1376.
16. T. Goto, J.Y. Lee, A. Teraminami, Y.I. Kim, S. Hirai, T. Uemura, H. Inoue, N. Takahashi, T. Kawada, Activation of PPAR-alpha stimulates both differentiation and fatty acid oxidation in adipocytes, J. Lipid Res., doi:10.1194/jlr.M011320.
17. Evans R.M., Barish G.D., Wang Y.X. PPARs and complex journey to obesity. Nat. Med. 2004, 10:1-7.
18. Desvergne B., Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 1999, 20:649-688.
19. Kang M.S., Hirai S., Goto T., Kuroyanagi K., Ezaki Y., Takahashi N., Kawada T. Dehydroabietic acid, herbal terpenoid, acts as ligands for PPARs in macrophages to regulate inflammation. Biochem. Biophys. Res. Commun. 2008, 369:333-338.
20. Takahashi N., Kang K.M., Kuroyanagi K., Goto T., Hirai S., Ohyama K., Lee J.Y., Yu R., Yano M., Sasaki T., Murakami S., Kawada T. Auraptene a citrus fruit compound regulates gene expression as a PPAR-alpha agonist in HepG2 hepatocytes. BioFactors 2008, 33:25-32.
21. Lefebvre P., Chinetti G., Fruchart J.C., Staels B. Sorting out the roles of PPAR-alpha in energy metabolism and vascular homeostasis. J. Clin. Invest. 2006, 116:571-580.
22. Knauf C., Rieusset J., Foretz M., Cani P.D., Uldry M., Hosokawa M., Martinez E., Bringart M., Waget A., Kersten S., Desvergne B., Gremlich S., Wahli W., Seydoux J., Delzenne N.M., Thorens B., Burcelin R. PPAR-alpha-null mice have increased white adipose tissue glucose utilization GLUT4 and fat mass: role in liver and brain. Endocrinology 2006, 147:4067-4078.
23. Kang M.S., Hirai S., Goto T., Kuroyanagi K., Kim I.Y., Ohyama K., Uemura T., Lee J.Y., Sakamoto T., Ezaki Y., Yu R., Takahashi N., Kawada T. Dehydroabietic acid a phytochemical acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation of mouse adipose tissues. BioFactors 2009, 35:442-448.
24. Fernandes-Santos C., Carneiro R.E., de-Souza-Mendonca L., Aguila M.B., Mandarim-de-Lacerda C.A. Pan-PPAR agonist beneficial effects in overweight mice fed a high-fat high-sucrose diet. Nutrition 2009, 25:818-827.
25. Ogawa S., Takeuchi K., Sugimura K., Fukuda M., Lee R., Ito S., Sato T. Bezafibrate reduces blood glucose in type-2 diabetes mellitus. Metabolism 2000, 49:331-334.