Dehdroabietic acid,a diterpene improves diabetes and hyperlipdemia in obese diabitic KK-Ay mice

BioFactors

Volumn 35, Issue 5, 2009, Pages 442-448

  Kang, Min Sook ^a,d   Hirai, Shizuka ^a   Goto, Tsuyoshi ^a   Kuroyanagi, Kayo ^a   Kim, Young Ii ^a   Ohyama, Kana ^a   Uemura, Taku ^a   Lee, Joo Young ^a   Sakamoto, Tomoya ^a   Ezaki, Yoichiro ^b   Yu, Rina ^c   Takahashi, Nobuyuki ^a   Kawada, Teruo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Arakawa Chemical Industries   (Japan)

^c University of Ulsan   (South Korea)

^d National Institute of Animal Science   (South Korea)

Author keywords

Dehydroabietic acid; Inflammation; Metabolic Syndrome; PPARs

Indexed keywords

ADIPONECTIN; BEZAFIBRATE; DEHYDROABIETIC ACID; GLUCOSE; INSULIN; MACROPHAGE ACTIVATING FACTOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIOGLITAZONE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ABIETANE DERIVATIVE; ADIPONECTIN, MOUSE; CCL2 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; CELL INFILTRATION; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; LIPID LIVER LEVEL; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; OVARY INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BIOSYNTHESIS; BLOOD; DRUG EFFECT; MACROPHAGE; METABOLISM; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY;

MUS;

ADIPONECTIN; ANIMALS; BLOOD GLUCOSE; CHEMOKINE CCL2; DIABETES MELLITUS, TYPE 2; DITERPENES, ABIETANE; HYPERLIPIDEMIAS; INSULIN; MACROPHAGES; MICE; MICE, OBESE; OBESITY; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70450250493     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.58     Document Type: Article

References (28)

1. Muredach, P., Reilly, M. B., Daniel, J., and Rader, M. D. (2003) 108, 1546-1551.
2. Miranda, P. J., DeFronzo, R. A., Califf, R. M., and Guyton, J. R. (2005) Metabolic syndrome: definition, pathophysiology, and mechanisms. Am. Heart. J. 149, 33-45.
3. Gregorie, F. M., Smas, C. M., and Sul, H. S. (1998) Understanding adipocyte differentiation. Physiol. Rev. 78, 783-809.
4. Fernández-Real, J. M., and Ricart, W. (2003) Insulin resistance and chronic cardiovascular inflammatory syndrome. Endo. Rev. 24, 278-301.
5. Ahima, R. S., and Flier, J. S. (2000) Adipose tissue as an endocrine organ. Trends Endocrinol. Metab. 11, 327-332.
6. Rajala, M. W., and Scherer, P. E. (2003) The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144, 3765-3773.
7. Lau, D. C. W., Dhillon, B., Yan, H., Szmitko, P. E., and Verma, S. (2005) Adipokines: molecular links between obesity and atherosclerosis. Am. J. Physiol. Heart. Circ. Physiol. 288, H2031-H2041.
8. Lehrke M., and Lazar, M. A. (2004) Inflamed about obesity. Nat. Med. 10, 126-127.
9. Kersten, S., Desvergne, B., and Wahli, W. (2000) Roles of PPARs in health and disease. Nature. 405, 421-424.
10. Hsu, M. H., Savas, U., Griffin, K. J., and Johnson, E. F. (2001) Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J. Biol. Chem. 276, 27950-27958.
11. Hansen, J. B., Zhang, H., Rasmussen, T. H., Petersen, R. K., Flindt, E. N., and Kristiansen K. (2001) PPAR-delta-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling. J. Biol. Chem. 276, 3175-3182.
12. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPAR-gamma 2, a lipid-activated transcription factor. Cell. 79, 1147-1156.
13. Lehman, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for PPAR-gamma. J. Biol. Chem. 270, 12953-12956.
14. Fagerberg, B., Edwards, S., Halmos, T., Lopatynski, J., Schuster, H., Stender, S., Stoa-Birketvedt, G., Tonstad, S., Halldórsdó ttir, S., and Gause-Nilsson, I. (2005) Tesaglitazar, a novel dual PPAR-alpha/gamma agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population. Diabetologia. 48, 1716-1725.
15. Elson, CE., Underbakke, GL., Hanson, P., Shrago, E., Wainberg, R. H., and Qureshi, A. A. (1989) Impact of lemongrass oil, an essential oil, on serum cholesterol. Lipids 24, 677-679.
16. Takahashi, N., Kawada, T., Goto, T., Kim, C. S., Taimatsu, A., Egawa, K., Yamamoto, T., Jisaka, M., Nishimura, K., Yokota, K., Yu, R., and Fushiki, T. (2003) Abietic acid activates PPAR-gamma in RAW264. Macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. FEBS Lett. 550, 190-194.
17. Takahashi, N., Kawada, T., Goto, T., Yamamoto, T., Taimatsu, A., Matsui, N., Kimura, K., Saito, M., Hosokawa, M., Miyashita, K., and Fushiki, T. (2002) Dual action of isoprenols from herbal medicines on both PPARgamma and PPAR-alpha in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett. 514, 315-322.
18. Goto, T., Takahashi, N., Kato, S., Egawa, K., Ebisu, S., Moriyama, T., Fushiki, T., and Kawada, T. (2005) Phytol directly activates PPAR-alpha and regulates gene expression involved in lipid metabolism in PPARalpha- expressing HepG2 hepatocytes. Biochem. Biophys. Res. Commun. 337, 440-445.
19. Kuroyanagi, K., Kang, M. S., Goto, T., Hirai, S., Ohyama, K., Kusudo, T., Yu, R., Yano, M., Sasaki, T., Takahashi, N., and Kawada, T. (2008) Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 366, 219-225.
20. Takahashi, N., Kang, M. S., Kuroyanagi, K., Goto, T., Hirai, S., Ohyama, K., Lee, J. Y., Yano, M., Sasaki, T., Murakami, S., and Kawada, T. (2008) Auraptene, a citrus fruit compound, regulates gene expression as a PPAR-alpha agonist in HepG2 hepatocytes. BioFactors. 33, 25-32.
21. Kang, M. S., Hirai, S., Goto, T., Kuroyanagi, K., Lee, J. Y., Uemura, T., Ezaki, Y., Takahashi, N., and Kawada, T. (2008) Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. Biochem. Biophys. Res. Commun. 369, 333-338.
22. Hirai, S., Kim, Y.-I., Goto, T., Kang, M. S., Yoshimura, M., Obata, A., Yu, R., and Kawada, T. (2007) Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages.Life. Sci. 81, 1272-1279.
23. Tsuchida, A., Yamauchi, T., Takekawa, S., Hada, Y., Ito, Y., Maki, T., and Kadowaki, T. (2005) PPAR-alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPAR-alpha, PPAR-gamma, and their combination. Diabetes. 54, 3358-3370.
24. Hasmall, S. C., James, N. H., Macdonald, N., Gonzalez, F. J., Peters, J. M., and Roberts, R. A. (2000) Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPAR-alpha and TNF-alpha.Mutat. Res. 448, 193-200.
25. Kershaw, E. E., Schupp, M., Guan, H.-P., Gardner, N. P., Lazar, M. A., and Flier, J. S. (2007) PPAR-gamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am. J. Physiol. Endocrinol. Metab. 293, E1736-E1745.
26. Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., and Glass, C. K. (1998) The PPAR-gamma is a negative regulator of macrophage activation. Nature. 391, 79-82.
27. Kang, J. H., Kim, C. S., Han, I. S., Kawada, T., and Yu, R. (2007) Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett. 581, 4389-4396.
28. Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., and Ferrante, A. W., Jr. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 112, 1796-1808.