HERG channel blockade by externally applied quaternary ammonium derivatives

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 6, 2011, Pages 1560-1566

  Choi, Kee Hyun ^a   Song, Chiman ^a   Shin, Dongyun ^b   Park, Sungnam ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b Gachon University College of Medicine   (South Korea)

^c Korea University   (South Korea)

Author keywords

Cation interaction; hERG channel; Hydrophobicity; Inactivation; Quaternary ammonium

Indexed keywords

POTASSIUM CHANNEL HERG; QUATERNARY AMMONIUM DERIVATIVE; TETRABUTYLAMMONIUM; TETRAHEPTYLAMMONIUM; TETRAHEXYLAMMONIUM; TETRAMETHYLAMMONIUM CHLORIDE; TETRAPENTYLAMMONIUM; TETRAPROPYLAMMONIUM; TETRYLAMMONIUM; TETRYLAMMONIUM CHLORIDE; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CARDIOTOXICITY; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CHEMICAL INTERACTION; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; FEMALE; HYDROPHOBICITY; INHIBITION KINETICS; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; WHOLE CELL;

ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION; HUMANS; KINETICS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; QUATERNARY AMMONIUM COMPOUNDS; TETRAETHYLAMMONIUM; THERMODYNAMICS;

EID: 79954838525     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.02.008     Document Type: Article

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