Neural correlates of error monitoring modulated by atomoxetine in healthy volunteers

Biological Psychiatry

Volumn 69, Issue 9, 2011, Pages 890-897

  Graf, Heiko ^a,d   Abler, Birgit ^a   Freudenmann, Roland ^a   Beschoner, Petra ^a   Schaeffeler, Elke ^b   Spitzer, Manfred ^a   Schwab, Matthias ^b,c   Grn, Georg ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^c University Hospital   (Germany)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

Atomoxetine; error monitoring; fMRI; Go NoGo task; inhibitory control

Indexed keywords

ATOMOXETINE; PLACEBO;

ALERTNESS; ANALYTICAL ERROR; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BEHAVIOR; BRAIN REGION; CARDIOVASCULAR FUNCTION; COGNITION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; ELECTROPHYSIOLOGY; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; MALE; NERVE CELL; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PATIENT MONITORING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SINGLE DRUG DOSE; TASK PERFORMANCE;

ADRENERGIC UPTAKE INHIBITORS; ADULT; ANALYSIS OF VARIANCE; ATTENTION; BRAIN MAPPING; DOUBLE-BLIND METHOD; EXECUTIVE FUNCTION; FRONTAL LOBE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INHIBITION (PSYCHOLOGY); MAGNETIC RESONANCE IMAGING; MALE; NEURONS; NEUROPSYCHOLOGICAL TESTS; PROPYLAMINES;

EID: 79954750357     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.10.018     Document Type: Article

References (66)

1. S.R. Chamberlain, N. Del Campo, J. Dowson, U. Mller, L. Clark, T.W. Robbins, and B.J. Sahakian Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder Biol Psychiatry 62 2007 977 984 (Pubitemid 47562368)
2. A.M. Passarotti, J.A. Sweeney, and M.N. Pavuluri Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder Psychiatry Res 181 2010 36 43
3. K. Rubia, S. Overmeyer, E. Taylor, M. Brammer, S.C. Williams, A. Simmons, and E.T. Bullmore Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: A study with functional MRI Am J Psychiatry 156 1999 891 896 (Pubitemid 29260344)
4. V. Menon, N.E. Adleman, C.D. White, G.H. Glover, and A.L. Reiss Error-related brain activation during a Go/NoGo response inhibition task Hum Brain Mapp 12 2001 131 143 (Pubitemid 32186917)
5. K.A. Kiehl, P.F. Liddle, and J.B. Hopfinger Error processing and the rostral anterior cingulate: An event-related fMRI study Psychophysiology 37 2000 216 223 (Pubitemid 30140286)
6. T.S. Braver, D.M. Barch, J.R. Gray, D.L. Molfese, and A. Snyder Anterior cingulate cortex and response conflict: Effects of frequency, inhibition and errors Cereb Cortex 11 2001 825 836 (Pubitemid 32800550)
7. K. Rubia, A.B. Smith, M.J. Brammer, and E. Taylor Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection Neuroimage 20 2003 351 358 (Pubitemid 37188523)
8. N.R. Horn, M. Dolan, R. Elliott, J.F. Deakin, and P.W. Woodruff Response inhibition and impulsivity: An fMRI study Neuropsychologia 41 2003 1959 1966 (Pubitemid 37297853)
9. W.J. Gehring, B. Goss, M.G. Coles, D.E. Meyer, and E.A. Donchin Neural system for error-detection and compensation Psychol Sci 4 1993 385 390
10. M. Falkenstein, J. Hohnsbein, and J. Hoormann Event-related potential correlates of errors in reaction tasks Electroencephalogr Clin Neurophysiol Suppl 44 1995 287 296
11. M.M. Botvinick, T.S. Braver, D.M. Barch, C.S. Carter, and J.D. Cohen Conflict monitoring and cognitive control Psychol Rev 108 2001 624 652 (Pubitemid 33604139)
12. M. Ullsperger, and D.Y. von Cramon Subprocesses of performance monitoring: A dissociation of error processing and response competition revealed by event-related fMRI and ERPs Neuroimage 14 2001 1387 1401 (Pubitemid 33124186)
13. M. Ullsperger, and D.Y. von Cramon Error monitoring using external feedback: Specific roles of the habenular complex, the reward system, and the cingulate motor area revealed by functional magnetic resonance imaging J Neurosci 23 2003 4308 4314 (Pubitemid 36958451)
14. V. Van Veen, and C.S. Carter The timing of action-monitoring processes in the anterior cingulate cortex J Cogn Neurosci 14 2002 593 602 (Pubitemid 34553655)
15. S.F. Taylor, E.R. Stern, and W.J. Gehring Neural systems for error monitoring: Recent findings and theoretical perspectives Neuroscientist 13 2007 160 172 (Pubitemid 46524318)
16. S. Debener, M. Ullsperger, M. Siegel, K. Fiehler, D.Y. von Cramon, and A.K. Engel Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring J Neurosci 25 2005 11730 11737 (Pubitemid 43098465)
17. H. Garavan, T.J. Ross, K. Murphy, R.A. Roche, and E.A. Stein Dissociable executive functions in the dynamic control of behavior: Inhibition, error detection, and correction Neuroimage 17 2002 1820 1829 (Pubitemid 36062772)
18. D.H. Mathalon, S.L. Whitfield, and J.M. Ford Anatomy of an error: ERP and fMRI Biol Psychol 64 2003 119 141 (Pubitemid 37351019)
19. G. Aston-Jones, and J.D. Cohen An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance Annu Rev Neurosci 28 2005 403 450 (Pubitemid 41098911)
20. G. Jocham, and M. Ullsperger Neuropharmacology of performance monitoring Neurosci Biobehav Rev 33 2009 48 60
21. D.T. Wong, P.G. Threlkeld, K.L. Best, and F.P. Bymaster A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain J Pharmacol Exp Ther 222 1982 61 65 (Pubitemid 12096999)
22. F.P. Bymaster, J.S. Katner, D.L. Nelson, S.K. Hemrick-Luecke, P.G. Threlkeld, and J.H. Heiligenstein Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: A potential mechanism for efficacy in attention deficit/hyperactivity disorder Neuropsychopharmacology 27 2002 699 711 (Pubitemid 35335888)
23. D. Michelson, D. Faries, J. Wernicke, D. Kelsey, K. Kendrick, and F.R. Sallee Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: A randomized, placebo-controlled, doseresponse study Pediatrics 108 2001 E83
24. D. Michelson, A.J. Allen, J. Busner, C. Casat, D. Dunn, and C. Kratochvil Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: A randomized, placebo-controlled study Am J Psychiatry 159 2002 1896 1901 (Pubitemid 35283256)
25. J.M. Sauer, B.J. Ring, and J.W. Witcher Clinical pharmacokinetics of atomoxetine Clin Pharmacokinet 44 2005 571 590 (Pubitemid 40994086)
26. S.R. Chamberlain, U. Mller, A.D. Blackwell, L. Clark, T.W. Robbins, and B.J. Sahakian Neurochemical modulation of response inhibition and probabilistic learning in humans Science 311 2006 861 863 (Pubitemid 43228852)
27. S.R. Chamberlain, A. Hampshire, U. Mller, K. Rubia, N. Del Campo, and K. Craig Atomoxetine modulates right inferior frontal activation during inhibitory control: A pharmacological functional magnetic resonance imaging study Biol Psychiatry 65 2009 550 555
28. J. Riba, A. Rodrguez-Fornells, A. Morte, T.F. Mnte, and M.J. Barbanoj Noradrenergic stimulation enhances human action monitoring J Neurosci 25 2005 4370 4374 (Pubitemid 40628781)
29. B.J. Ring, J.S. Gillespie, J.A. Eckstein, and S.A. Wrighton Identification of the human cytochromes P450 responsible for atomoxetine metabolism Drug Metab Dispos 30 2002 319 323 (Pubitemid 34175024)
30. U.M. Zanger, M. Turpeinen, K. Klein, and M. Schwab Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation Anal Bioanal Chem 392 2008 1093 1108
31. W. Schroth, M.P. Goetz, U. Hamann, P.A. Fasching, M. Schmidt, and S. Winter Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen JAMA 302 2009 1429 1436
32. D. Michelson, H.A. Read, D.D. Ruff, J. Witcher, S. Zhang, and J. McCracken CYP2D6 and clinical response to atomoxetine in children and adolescents with ADHD J Am Acad Child Adolesc Psychiatry 46 2007 242 251 (Pubitemid 46148423)
33. K. Mrike, K.T. Kivist, E. Schaeffeler, C. Jgle, S. Igel, and S. Drescher Propafenone for the prevention of atrial tachyarrhythmias after cardiac surgery: A randomized, double-blind placebo-controlled trial Clin Pharmacol Ther 84 2008 104 110 (Pubitemid 351861491)
34. J.W. Witcher, A. Long, B. Smith, J.M. Sauer, J. Heilgenstein, and T. Wilens Atomoxetine pharmacokinetics in children and adolescents with attention deficit hyperactivity disorder J Child Adolesc Psychopharmacol 13 2003 53 63 (Pubitemid 36570188)
35. A.H. Oliveto, W.K. Bickel, J.R. Hughes, P.J. Shea, S.T. Higgins, and J.W. Fenwick Caffeine drug discrimination in humans: acquisition, specificity and correlation with self-reports J Pharmacol Exp Ther 261 1992 885 894
36. P. Zimmermann, and B. Fimm Testbatterie zur Erfassung von Aufmerksamkeitsstrungen, Version 1.02 1993 Psytest Freiburg, Germany
37. W. Sturm, F. Longoni, B. Fimm, T. Dietrich, S. Weis, and S. Kemna Network for auditory intrinsic alertness: A PET study Neuropsychologia 42 2004 563 568 (Pubitemid 38064280)
38. H. Jasper, and S. Sharpless Habituation of the arousal reaction Brain 79 1956 655 680
39. R.D. Rafal, and M.I. Posner Deficits in human visual spatial attention following thalamic lesions Proc Natl Acad Sci U S A 84 1987 7349 7353
40. B.A. Eriksen, and C.W. Eriksen Effects of noise letters upon the identification of a target letter in a nonsearch task Percept Psychophys 16 1974 143 149
41. M. Ruchsow, M. Spitzer, G. Grn, J. Grothe, and M. Kiefer Error processing and impulsiveness in normals: Evidence from event-related potentials Brain Res Cogn Brain Res 24 2005 317 325 (Pubitemid 40922639)
42. M. Ruchsow, H. Walter, A. Buchheim, P. Martius, M. Spitzer, and H. Kchele Electrophysiological correlates of error processing in borderline personality disorder Biol Psychol 72 2006 133 140
43. D. Michelson, L. Adler, T. Spencer, F.W. Reimherr, S.A. West, and A.J. Allen Atomoxetine in adults with ADHD: Two randomized, placebo-controlled studies Biol Psychiatry 53 2003 112 120 (Pubitemid 36126473)
44. L.A. Adler, T.J. Spencer, D.R. Milton, R.J. Moore, and D. Michelson Long-term, open-label study of the safety and efficacy of atomoxetine in adults with attention-deficit/hyperactivity disorder: An interim analysis J Clin Psychiatry 66 2005 294 299 (Pubitemid 40476751)
45. S.V. Faraone, J. Biederman, T. Spencer, D. Michelson, L. Adler, F. Reimherr, and S.J. Glatt Efficacy of atomoxetine in adult attention-deficit/ hyperactivity disorder: A drug-placebo response curve analysis Behav Brain Funct 1 2005 16
46. D.K. Kelsey, C.R. Sumner, C.D. Casat, D.L. Coury, H. Quintana, and K.E. Saylor Once-daily atomoxetine treatment for children with attention-deficit/ hyperactivity disorder, including an assessment of evening and morning behavior: A double-blind, placebo-controlled trial Pediatrics 114 2004 e1 e8
47. M. Weiss, R. Tannock, C. Kratochvil, D. Dunn, J. Velez-Borras, and C. Thomason A randomized, placebo-controlled study of once-daily atomoxetine in the school setting in children with ADHD J Am Acad Child Adolesc Psychiatry 44 2005 647 655 (Pubitemid 40875359)
48. S.H. Heil, H.W. Holmes, W.K. Bickel, S.T. Higgins, G.J. Badger, H.F. Laws, and D.E. Faries Comparison of the subjective, physiological, and psychomotor effects of atomoxetine and methylphenidate in light drug users Drug Alcohol Depend 67 2002 149 156 (Pubitemid 34722402)
49. J.F. Wernicke, and C.J. Kratochvil Safety profile of atomoxetine in the treatment of children and adolescents with ADHD J Clin Psychiatry 63 2002 50 55 (Pubitemid 36025588)
50. A.A. Noorbala, and S. Akhondzadeh Attention-deficit/hyperactivity disorder: Etiology and pharmacotherapy Arch Iran Med 9 2006 374 380 (Pubitemid 44803582)
51. A.R. Aron, T.W. Robbins, and R.A. Poldrack Inhibition and the right inferior frontal cortex Trends Cogn Sci 8 2004 170 177 (Pubitemid 38429927)
52. A. Hampshire, S.R. Chamberlain, M.M. Monti, J. Duncan, and A.M. Owen The role of the right inferior frontal gyrus: Inhibition and attentional control Neuroimage 50 2010 1313 1319
53. N.U. Dosenbach, K.M. Visscher, E.D. Palmer, F.M. Miezin, K.K. Wenger, and H.C. Kang A core system for the implementation of task sets Neuron 50 2006 799 812 (Pubitemid 43775735)
54. D. Badre, and A.D. Wagner Left ventrolateral prefrontal cortex and the cognitive control of memory Neuropsychologia 45 2007 2883 2901 (Pubitemid 47381456)
55. P. Nachev, G. Rees, A. Parton, C. Kennard, and M. Husain Volition and conflict in human medial frontal cortex Curr Biol 15 2005 122 128
56. M. Falkenstein, J. Hohnsbein, J. Hoormann, and L. Blanke Effects of crossmodal divided attention on late ERP components II. Error processing in choice reaction tasks Electroencephalogr Clin Neurophysiol 78 1991 447 455
57. M.G. Coles, M.K. Scheffers, and C.B. Holroyd Why is there an ERN/NE on correct trials? Response representations, stimulus-related components, and the theory of error-processing Biol Psychol 56 2001 173 189 (Pubitemid 33713456)
58. C.S. Carter, T.S. Braver, D.M. Barch, M.M. Botvinick, D. Noll, and J.D. Cohen Anterior cingulate cortex, error detection, and the online monitoring of performance Science 280 1998 747 749 (Pubitemid 28243351)
59. J.G. Kerns, J.D. Cohen, A.W. MacDonald 3rd, R.Y. Cho, V.A. Stenger, and C.S. Carter Anterior cingulate conflict monitoring and adjustments in control Science 303 2004 1023 1026 (Pubitemid 38209708)
60. N. Yeung, M.M. Botvinick, and J.D. Cohen The neural basis of error detection: Conflict monitoring and the error-related negativity Psychol Rev 111 2004 931 959 (Pubitemid 39375082)
61. G. Jocham, J. Neumann, T.A. Klein, C. Danielmeier, and M. Ullsperger Adaptive coding of action values in the human rostral cingulate zone J Neurosci 29 2009 7489 7496
62. T.E. Behrens, M.W. Woolrich, M.E. Walton, and M.F. Rushworth Learning the value of information in an uncertain world Nat Neurosci 10 2007 1214 1221 (Pubitemid 47339952)
63. C.W. Berridge, and B.D. Waterhouse The locus coeruleus-noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes Brain Res Rev 42 2003 33 84 (Pubitemid 36369264)
64. E.R. Samuels, and E. Szabadi Functional neuroanatomy of the noradrenergic locus coeruleus: Its roles in the regulation of arousal and autonomic function part I: Principles of functional organisation Curr Neuropharmacol 6 2008 235 253
65. K. Konrad, T. Gunther, C. Hanisch, and B. Herpertz-Dahlmann Differential effects of methylphenidate on attentional functions in children with attention-deficit/hyperactivity disorder J Am Acad Child Adolesc Psychiatry 43 2004 191 198
66. J. Prince Catecholamine dysfunction in attention-deficit/hyperactivity disorder: An update J Clin Psychopharmacol 28 2008 S39 S45