Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Chiu, Sheng Chun ^a,b   Wang, Mei Jen ^a,b   Yang, Hsueh Hui ^b   Chen, Shee Ping ^b   Huang, Sung Ying ^c   Chen, Yi Lin ^d   Lin, Shinn Zong ^e   Harn, Horng Jyh ^f   Pang, Cheng Yoong ^a,b  

^a TZU CHI UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c MACKAY MEMORIAL HOSPITAL   (Taiwan)

^d NATIONAL ILAN UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CDC25C PHOSPHATASE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; EARLY GROWTH RESPONSE FACTOR 1; HERBACEOUS AGENT; ISOCHAIHULACTONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PROTEIN BCL 2; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; CDC25C PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; GDF15 PROTEIN, HUMAN; GROWTH DIFFERENTIATION FACTOR 15; MITOGEN ACTIVATED PROTEIN KINASE 9; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE 1;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BUPLEURUM; BUPLEURUM SCORZONERIFOLIUM; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; EARLY GROWTH RESPONSE GENE 1; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; FLOW CYTOMETRY; GENE; HUMAN; HUMAN CELL; NONSTEROID ANTIINFLAMMATORY DRUG ACTIVATED GENE 1; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL CYCLE; CELL SURVIVAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROSTATE TUMOR; RNA INTERFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

4-BUTYROLACTONE; ANTHRACENES; BENZODIOXOLES; BLOTTING, WESTERN; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN B1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; EARLY GROWTH RESPONSE PROTEIN 1; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79954623617     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-146     Document Type: Article

References (32)

1. Hayat MJ, Howlader N, Reichman ME, Edwards BK. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist 2007, 12(1):20-37. 10.1634/theoncologist.12-1-20, 17227898.
2. Xiao H, Verdier-Pinard P, Fernandez-Fuentes N, Burd B, Angeletti R, Fiser A, Horwitz SB, Orr GA. Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci USA 2006, 103(27):10166-10173. 10.1073/pnas.0603704103, 1502429, 16801540.
3. Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by taxol. Nature 1979, 277(5698):665-667. 10.1038/277665a0, 423966.
4. Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ. Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Lett 2005, 222(2):183-193. 10.1016/j.canlet.2004.10.015, 15863267.
5. Cheng YL, Chang WL, Lee SC, Liu YG, Lin HC, Chen CJ, Yen CY, Yu DS, Lin SZ, Harn HJ. Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci 2003, 73(18):2383-2394. 10.1016/S0024-3205(03)00648-9, 12941440.
6. Chen YL, Lin SZ, Chang WL, Cheng YL, Harn HJ. Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation. Life Sci 2005, 76(21):2409-2420. 10.1016/j.lfs.2004.09.044, 15763073.
7. Chen YL, Lin SZ, Chang JY, Cheng YL, Tsai NM, Chen SP, Chang WL, Harn HJ. In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells. Biochem Pharmacol 2006, 72(3):308-319. 10.1016/j.bcp.2006.04.031, 16782069.
8. Tomioka K, Ishiguro T, Iitaka Y, Koga K. Stereoselective reactions. XII. Synthesis of antitumor-active steganacin analogs, picrosteganol and epipicrosteganol, by selective isomerization. Chem Pharm Bull (Tokyo) 1986, 34(4):1501-1504.
9. Chen YL, Lin PC, Chen SP, Lin CC, Tsai NM, Cheng YL, Chang WL, Lin SZ, Harn HJ. Activation of nonsteroidal anti-inflammatory drug-activated gene-1 via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells. J Pharmacol Exp Ther 2007, 323(2):746-756. 10.1124/jpet.107.126193, 17715378.
10. Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 1993, 53(19):4701-4714.
11. Bulavin DV, Higashimoto Y, Demidenko ZN, Meek S, Graves P, Phillips C, Zhao H, Moody SA, Appella E, Piwnica-Worms H, Fornace AJ. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol 2003, 5(6):545-551. 10.1038/ncb994, 12766774.
12. Lammer C, Wagerer S, Saffrich R, Mertens D, Ansorge W, Hoffmann I. The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J Cell Sci 1998, 111(Pt 16):2445-2453.
13. Gould KL, Nurse P. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 1989, 342(6245):39-45. 10.1038/342039a0, 2682257.
14. Singh RP, Agrawal P, Yim D, Agarwal C, Agarwal R. Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis 2005, 26(4):845-854. 10.1093/carcin/bgi014, 15637089.
15. Zhang YX, Kong CZ, Wang LH, Li JY, Liu XK, Xu B, Xu CL, Sun YH. Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. J Cell Biochem 109(4):764-773.
16. Du L, Lyle CS, Chambers TC. Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction. Oncogene 2005, 24(1):107-117. 10.1038/sj.onc.1208189, 15531923.
17. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prevost MC, Alzari PM, Kroemer G. Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med 1999, 189(2):381-394. 10.1084/jem.189.2.381, 2192979, 9892620.
18. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999, 144(2):281-292. 10.1083/jcb.144.2.281, 2132895, 9922454.
19. Liao CH, Pan SL, Guh JH, Chang YL, Pai HC, Lin CH, Teng CM. Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo. Carcinogenesis 2005, 26(5):968-975. 10.1093/carcin/bgi041, 15705600.
20. Yamaguchi K, Lee SH, Eling TE, Baek SJ. A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol Cancer Ther 2006, 5(5):1352-1361. 10.1158/1535-7163.MCT-05-0528, 16731769.
21. Baek SJ, Kim JS, Moore SM, Lee SH, Martinez J, Eling TE. Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol Pharmacol 2005, 67(2):356-364. 10.1124/mol.104.005108, 15509713.
22. Newman D, Sakaue M, Koo JS, Kim KS, Baek SJ, Eling T, Jetten AM. Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol Pharmacol 2003, 63(3):557-564. 10.1124/mol.63.3.557, 12606762.
23. Lee SH, Kim JS, Yamaguchi K, Eling TE, Baek SJ. Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem Biophys Res Commun 2005, 328(1):63-69. 10.1016/j.bbrc.2004.12.138, 15670751.
24. Eling TE, Baek SJ, Shim M, Lee CH. NSAID activated gene (NAG-1), a modulator of tumorigenesis. J Biochem Mol Biol 2006, 39(6):649-655. 10.5483/BMBRep.2006.39.6.649, 17129398.
25. Paralkar VM, Vail AL, Grasser WA, Brown TA, Xu H, Vukicevic S, Ke HZ, Qi H, Owen TA, Thompson DD. Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J Biol Chem 1998, 273(22):13760-13767. 10.1074/jbc.273.22.13760, 9593718.
26. Shim M, Eling TE. Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells. J Biol Chem 2005, 280(19):18636-18642. 10.1074/jbc.M414613200, 15757899.
27. Welsh JB, Sapinoso LM, Kern SG, Brown DA, Liu T, Bauskin AR, Ward RL, Hawkins NJ, Quinn DI, Russell PJ, Sutherland RL, Breit SN, Moskaluk CA, Frierson HF, Hampton GM. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci USA 2003, 100(6):3410-3415. 10.1073/pnas.0530278100, 152306, 12624183.
28. Karan D, Chen SJ, Johansson SL, Singh AP, Paralkar VM, Lin MF, Batra SK. Dysregulated expression of MIC-1/PDF in human prostate tumor cells. Biochem Biophys Res Commun 2003, 305(3):598-604. 10.1016/S0006-291X(03)00823-4, 12763036.
29. Wang D, Dubois RN. Prostaglandins and cancer. Gut 2006, 55(1):115-122. 10.1136/gut.2004.047100, 1856377, 16118353.
30. Iguchi G, Chrysovergis K, Lee SH, Baek SJ, Langenbach R, Eling TE. A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Lett 2009, 282(2):152-158. 10.1016/j.canlet.2009.03.006, 19375854.
31. Baek SJ, Kim KS, Nixon JB, Wilson LC, Eling TE. Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol Pharmacol 2001, 59(4):901-908.
32. Macleod KF. The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer?. J Clin Invest 120, 12:4179-4182.