Simplified quantification of myocardial flow reserve with flurpiridaz F 18: Validation with microspheres in a pig model

Journal of Nuclear Medicine

Volumn 52, Issue 4, 2011, Pages 617-624

  Sherif, Hossam M ^a,b   Nekolla, Stephan G ^a   Saraste, Antti ^a,c   Reder, Sybille ^a   Yu, Ming ^d   Robinson, Simon ^d   Schwaiger, Markus ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b CAIRO UNIVERSITY   (Egypt)

^c UNIVERSITY OF TURKU   (Finland)

^d Clinical Research   (United States)

Author keywords

18F BMS747158 02; Flow reserve; Flurpiridaz F 18; PE.T.; Retention

Indexed keywords

ADENOSINE; DOBUTAMINE; FLURPIRIDAZ F 18; MICROSPHERE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY FLOW RESERVE; DRUG UPTAKE; HEART MUSCLE PERFUSION; IMAGE RECONSTRUCTION; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ADENOSINE; ANIMALS; CARDIOTONIC AGENTS; CORONARY CIRCULATION; DOBUTAMINE; GATED BLOOD-POOL IMAGING; HEART; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSPHERES; MYOCARDIUM; POSITRON-EMISSION TOMOGRAPHY; PYRIDAZINES; RADIOPHARMACEUTICALS; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SCINTILLATION COUNTING; SWINE;

EID: 79954613958     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.110.083196     Document Type: Article

References (37)

1. Gibbons RJ, Valeti US, Araoz PA, et al. The quantification of infarct size. J Am Coll Cardiol. 2004;44:1533-1542. (Pubitemid 39377707)
2. Schwaiger M. Myocardial perfusion imaging with PET. J Nucl Med. 1994;35: 693-698. (Pubitemid 24114572)
3. Knuuti J, Kajander S, Mäki M, et al. Quantification of myocardial blood flow will reform the detection of CAD. J Nucl Cardiol. 2009;16:497-506.
4. Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360:213-224.
5. George RT, Arbab-Zadeh A, Miller JM, et al. Adenosine stress 64- and 256- row detector computed tomography angiography and perfusion imaging: A pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia. Circ Cardiovasc Imaging. 2009;2:174-182.
6. Kaufmann PA, Camici PG. Myocardial blood flow measurement by PET: Technical aspects and clinical applications. J Nucl Med. 2005;46:75-88. (Pubitemid 43086001)
7. Lee DC, Johnson NP. Quantification of absolute myocardial blood flow by magnetic resonance perfusion imaging. J Am Coll Cardiol Imaging. 2009;2:761-770.
8. Dawson D, Rinkevich D, Belcik T, et al. Measurement of myocardial blood flow velocity reserve with myocardial contrast echocardiography in patients with suspected coronary artery disease: Comparison with quantitative gated technetium 99m sestamibi single photon emission computed tomography. J Am Soc Echocardiogr. 2003;16:1171-1177. (Pubitemid 37371662)
9. Parkash R, deKemp RA, Ruddy TD, et al. Potential utility of 82Rb PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol. 2004;11:440-449. (Pubitemid 39115288)
10. Dorbala S, Hassan A, Heinonen T, et al. Coronary vasodilator reserve and Framingham risk scores in subjects at risk for coronary artery disease. J Nucl Cardiol. 2006;13:761-767. (Pubitemid 44890806)
11. Higuchi T, Abletshauser C, Nekolla SG, et al. Effect of the angiotensin receptor blocker Valsartan on coronary microvascular flow reserve in moderately hypertensive patients with stable coronary artery disease. Microcirculation. 2007;14:805-812. (Pubitemid 350131388)
12. Muzik O, Beanlands RS, Hutchins GD, et al. Validation of 13N ammonia tracer kinetic model for quantification of myocardial blood flow using PET. J Nucl Med. 1993;34:83-91. (Pubitemid 23014231)
13. Muzik O, Beanlands R, Wolfe E, Hutchins GD, Schwaiger M. Automated region definition for cardiac nitrogen-13-ammonia PET imaging. J Nucl Med. 1993;34: 336-344. (Pubitemid 23056420)
14. El Fakhri G, Kardan A, Sitek A, et al. Reproducibility and accuracy of quantitative myocardial blood flow assessment with 82Rb PET: Comparison with 13N ammonia PET. J Nucl Med. 2009;50:1062-1071.
15. Camici PG, Rimoldi OE. The clinical value of myocardial blood flow measurement. J Nucl Med. 2009;50:1076-1087.
16. Sawada S, Muzik O, Beanlands RS, et al. Interobserver and interstudy variability of myocardial blood flow and flow-reserve measurements with nitrogen 13 ammonia- labeled positron emission tomography. J Nucl Cardiol. 1995;2:413-422.
17. Herzog BA, Husmann L, Valenta I, et al. Long-term prognostic value of 13N ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol. 2009;54:150-156.
18. Lautamäki R, George RT, Kitagawa K, et al. 82Rb PET-CT for quantitative assessment of myocardial blood flow: Validation in a canine model of coronary artery stenosis. Eur J Nucl Med Mol Imaging. 2009;36:576-586.
19. Lortie M, Beanlands RS, Yoshinaga K, et al. Quantification of myocardial blood flow with 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging. 2007;34:1765-1774. (Pubitemid 47599057)
20. 18F BMS747158-02 in cardiomyocytes: A novel PET myocardial imaging agent. J Nucl Cardiol. 2007;14:782-788. (Pubitemid 350082573)
21. 18F BMS747158-02: A novel PET myocardial perfusion imaging agent. J Nucl Cardiol. 2007;14:789-798. (Pubitemid 350082572)
22. 18F BMS747158-02: Comparison to 13N ammonia and validation with microspheres in a pig model. Circulation. 2009;119:2333-2342.
23. Woodard HQ, Bigler RE, Freed B, et al. Expression of tissue isotope distribution. J Nucl Med. 1975;16:958-959.
24. Bellina CR, Parodi O, Camici P, et al. Simultaneous in vitro and in vivo validation of 13N ammonia for the assessment of regional myocardial blood flow. J Nucl Med. 1990;31:1335-1343. (Pubitemid 20245930)
25. Yoshida K, Mullani N, Gould KL. Coronary flow and flow reserve by PET simplified for clinical applications using 82Rb or 13N ammonia. J Nucl Med. 1996;37:1701-1712. (Pubitemid 26337184)
26. Taki J, Fujino S, Nakajima K, et al. 99mTc sestamibi retention characteristics during pharmacologic hyperemia in human myocardium: Comparison with coronary flow reserve measured by Doppler flowire. J Nucl Med. 2001;42:1457-1463. (Pubitemid 32953123)
27. Kitsiou AN, Bacharach SL, Bartlett ML, et al. 13N ammonia myocardial blood flow and uptake: Relation to functional outcome of asynergic regions after revascularization. J Am Coll Cardiol. 1999;33:678-686.
28. Buck A, Nguyen N, Burger C, et al. Quantitative evaluation of manganese-52m as a myocardial perfusion tracer in pigs using positron emission tomography. Eur J Nucl Med. 1996;23:1619-1627. (Pubitemid 27023059)
29. Matsunari I, Haas F, Nguyen N, et al. Comparison of sestamibi, tetrofosmin, and Q12 retention in porcine myocardium. J Nucl Med. 2001;42:818-823. (Pubitemid 32453475)
30. 18F-labeled myocardial perfusion tracer. J Nucl Med. 2008;49:630-636. (Pubitemid 351520612)
31. Heymann MA, Payne BD, Hoffman JI, et al. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis. 1977;20:55-79. (Pubitemid 8145634)
32. Tai YC, Ruangma A, Rowland D, et al. Performance evaluation of the microPET Focus: A third-generation microPET scanner dedicated to animal imaging. J Nucl Med. 2005;46:455-463. (Pubitemid 43093155)
33. Strauss LG, Conti PS. The applications of PET in clinical oncology. J Nucl Med. 1991;32:623-648.
34. Leppo JA, Meerdink DJ. Comparison of the myocardial uptake of Tm-labeled isonitrile analogue and Tl. Circ Res. 1989;65:632-639. (Pubitemid 19226439)
35. Mullani NA, Goldstein RA, Gould KL, et al. Myocardial perfusion with 82Rb: Measurement of extraction fraction and flow with external detectors. J Nucl Med. 1983;24:898-906. (Pubitemid 14236772)
36. 18F-labeled positronemission tomography perfusion tracer for the assessment of myocardial infarct size in rats. Circ Cardiovasc Imaging. 2009;2:77-84.
37. Chow BJ, Ananthasubramaniam K, Dekemp RA, et al. Comparison of treadmill exercise versus dipyridamole stress with myocardial perfusion imaging using 82Rb positron emission tomography. J Am Coll Cardiol. 2005;45:1227-1234. (Pubitemid 40523142)