Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02: Comparison to 13N-ammonia and validation with microspheres in a pig model

Circulation

Volumn 119, Issue 17, 2009, Pages 2333-2342

  Nekolla, S G ^a   Reder, S ^a   Saraste, A ^a   Higuchi, T ^a   Dzewas, G ^a   Preissel, A ^b   Huisman, M ^a   Poethko, T ^a   Schuster, T ^b   Yu, M ^c   Robinson, S ^a   Casebier, D ^c   Henke, J ^b   Wester, H J ^a   Schwaiger, M ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c A Subsidiary of Lantheus Holdings   (United States)

Author keywords

Ischemia; Microspheres; Perfusion; Positron emission tomography; Regional blood flow

Indexed keywords

AMMONIA N 13; BMS 747158 02 F 18; FLUORINE 18; MICROSPHERE; UNCLASSIFIED DRUG; AMMONIA; BMS 747158 02; BMS 747158-02; CONTRAST MEDIUM; DIAGNOSTIC AGENT; FLUORINE; NITROGEN; PYRIDAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; EVALUATION RESEARCH; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE PERFUSION; HEMODYNAMICS; IMAGE QUALITY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PHARMACOLOGIC STRESS TESTING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; VALIDATION STUDY; ANIMAL; BLOOD FLOW; COMPARATIVE STUDY; CORONARY BLOOD VESSEL; EVALUATION; HALF LIFE TIME; HEART SCINTISCANNING; METHODOLOGY; SWINE;

AMMONIA; ANIMALS; CONTRAST MEDIA; CORONARY VESSELS; FLUORINE RADIOISOTOPES; HALF-LIFE; MICROSPHERES; MYOCARDIAL PERFUSION IMAGING; NITROGEN ISOTOPES; POSITRON-EMISSION TOMOGRAPHY; PYRIDAZINES; REGIONAL BLOOD FLOW; SWINE;

EID: 66349108176     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.797761     Document Type: Article

References (33)

1. Kaufmann PA, Camici PG. Myocardial blood flow measurement by PET: technical aspects and clinical applications. J Nucl Med. 2005;46:75-88.
2. Di Carli MF, Hachamovitch R. New technology for noninvasive evaluation of coronary artery disease. Circulation. 2007;115:1464-1480.
3. Schindler TH, Nitzsche EU, Schelbert HR, Olschewski M, Sayre J, Mix M, Brink I, Zhang XL, Kreissl M, Magosaki N, Just H, Solzbach U. Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events. J Am Coll Cardiol. 2005;45: 1505-1512.
4. Neglia D, Michelassi C, Trivieri MG, Sambuceti G, Giorgetti A, Pratali L, Gallopin M, Salvadori P, Sorace O, Carpeggiani C, Poddighe R, L'Abbate A, Parodi O. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation. 2002;105:186-193.
5. Cecchi F, Olivotto I, Gistri R, Lorenzoni R, Chiriatti G, Camici PG. Coronary microvascular dysfunction and prognosis in hypertrophic car-diomyopathy. N Engl J Med. 2003;349:1027-1035.
6. Sampson UK, Dorbala S, Limaye A, Kwong R, Di Carli MF. Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease. J Am Coll Cardiol. 2007;49:1052-1058.
7. Yalamanchili P, Wexler E, Hayes M, Yu M, Bozek J, Kagan M, Radeke HS, Azure M, Purohit A, Casebier DS, Robinson SP. Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent. J Nucl Cardiol. 2007;14:782-788.
8. Schuler F, Casida JE. The insecticide target in the PSST submit of complex I. Pest Manag Sci. 2001;57:932-940.
9. Huisman MC, Higuchi T, Reder S, Nekolla SG, Poethko T, Wester HJ, Ziegler SI, Casebier DS, Robinson SP, Schwaiger M. Initial characterization of an 18F-labeled myocardial perfusion tracer. J Nucl Med. 2008;49:630-636.
10. Deutsch E, Ketring AR, Libson K, Vanderheyden JL, Hirth WW. The Noah's Ark experiment: species dependent biodistributions of cationic 99mTc complexes. Int J Rad Appl Instrum B. 1989;16:191-232.
11. Heymann MA, Payne BD, Hoffman JI, Rudolph AM. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis. 1977;20:55-79.
12. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging. 2002;18: 539-542.
13. Nekolla SG, Miethaner C, Nguyen N, Ziegler SI, Schwaiger M. Repro-ducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography. Eur J Nucl Med. 1998;25:1313-1321.
14. Yu M, Guaraldi M, Kagan M, Mistry M, McDonald J, Bozek J, Yalamanchili P, Hayes M, Azure M, Purohit A, Radeke H, Casebier DS, Robinson SP. Assessment of (18)F-labeled mitochondrial complex I inhibitors as PET myocardial perfusion imaging agents in rats, rabbits, and primates. Eur J Nucl Med Mol Imaging. 2009;36:63-72.
15. Hutchins GD, Schwaiger M, Rosenspire KC, Krivokapich J, Schelbert H, Kuhl DE. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol. 1990;15:1032-1042.
16. Press WH, Flannery BP, Teukolsky SA, Vetterling WT. Numerical Recipes in C Cambridge, United Kingdom; Cambridge University Press; 1988.
17. Muzik O, Beanlands RS, Hutchins GD, Mangner TJ, Nguyen N, Schwaiger M. Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET. J Nucl Med. 1993;34:83-91.
18. Merhige ME, Breen WJ, Shelton V, Houston T, D'Arcy BJ, Perna AF. Impact of myocardial perfusion imaging with PET and (82)Rb on downstream invasive procedure utilization, costs, and outcomes in coronary disease management. J Nucl Med. 2007;48:1069-1076.
19. Huisman MC, Higuchi T, Reder S, Nekolla SG, Poethko T, Wester HJ, Ziegler SI, Casebier DS, Robinson SP, Schwaiger M. Initial characterization of an 18F-labeled myocardial perfusion tracer. J Nucl Med. 2008;49:630-636.
20. Madar I, Ravert H, Dipaula A, Du Y, Dannals RF, Becker L. Assessment of severity of coronary artery stenosis in a canine model using the PET agent 18F-fluorobenzyl triphenyl phosphonium: comparison with 99mTc-tetrofosmin. J Nucl Med. 2007;48:1021-1030.
21. Kapur A, Latus KA, Davies G, Dhawan RT, Eastick S, Jarritt PH, Roussakis G, Young MC, Anagnostopoulos C, Bomanji J, Costa DC, Pennell DJ, Prvulovich EM, Ell PJ, Underwood SR. A comparison of three radionuclide myocardial perfusion tracers in clinical practice: the ROBUST study. Eur J Nucl Med Mol Imaging. 2002;29:1608-1616.
22. Hughes GC, Post MJ, Simons M, Annex BH. Translational physiology: porcine models of human coronary artery disease: implications for pre-clinical trials of therapeutic angiogenesis. J Appl Physiol. 2003;94: 1689-1701.
23. Higuchi T, Nekolla SG, Huisman MM, Reder S, Poethko T, Yu M, Wester HJ, Casebier DS, Robinson SP, Botnar RM, Schwaiger M. A new 18F-labeled myocardial PET tracer: myocardial uptake after permanent and transient coronary occlusion in rats. J Nucl Med. 2008;49:1715-1722.
24. Yu M, Guaraldi MT, Mistry M, Kagan M, McDonald JL, Drew K, Radeke H, Azure M, Purohit A, Casebier DS, Robinson SP. BMS-747158-02: a novel PET myocardial perfusion imaging agent. J Nucl Cardiol. 2007;14:789-798.
25. Bellina CR, Parodi O, Camici P, Salvadori PA, Taddei L, Fusani L, Guzzardi R, Klassen GA, L'Abbate AL, Donate L. Simultaneous in vitro and in vivo validation of nitrogen-13-ammonia for the assessment of regional myocardial blood flow. J Nucl Med. 1990;31:1335-1343.
26. Yoshida K, Mullani N, Gould KL. Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia. J Nucl Med. 1996;37:1701-1712.
27. 201T1 in a model of acute coronary reperfusion. Circulation. 1996;94:2605-2613.
28. Schomig A, Kastrati A, Dirschinger J, Mehilli J, Schricke U, Pache J, Martinoff S, Neumann FJ, Schwaiger M, Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. N Engl J Med. 2000;343:385-391.
29. Maddahi JSC, Czernin J, Huang H, Schelbert H, Wijatyk A, Hibberd M, Lazewatsky J, Sparks R Phelps M. First human study of BMS747158, a novel F-18 labeled tracer for myocardial perfusion imaging. J Nucl Med. 2008;49:70P.
30. Stabin MG. Radiopharmaceuticals for nuclear cardiology: radiation dosimetry, uncertainties, and risk. J Nucl Med. 2008;49:1555-1563.
31. Glover DK, Gropler RJ. Journey to find the ideal PET flow tracer for clinical use: are we there yet? J Nucl Cardiol. 2007;14:765-768.
32. Scheubel RJ, Tostlebe M, Simm A, Rohrbach S, Prondzinsky R, Gellerich FN, Silber RE, Holtz J. Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression. J Am Coll Cardiol. 2002;40:2174-2181.
33. Paradies G, Petrosillo G, Pistolese M, Di Venosa N, Federici A, Ruggiero FM. Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin. Circ Res. 2004;94:53-59.