Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma

Cancer Research

Volumn 71, Issue 8, 2011, Pages 3000-3008

  Qin, Hai De ^a   Shugart, Yin Yao ^b   Bei, Jin Xin ^a   Pan, Qing Hua ^a   Chen, Lina ^c   Feng, Qi Sheng ^a   Chen, Li Zhen ^a   Huang, Wei ^d   Liu, Jian Jun ^e   Jorgensen, Timothy J ^f   Zeng, Yi Xin ^a   Jia, Wei Hua ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^e GENOME INSTITUTE OF SINGAPORE   (Singapore)

^f GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRCA2 GENE; CANCER RISK; CASE CONTROL STUDY; CHINA; CONTROLLED STUDY; DNA REPAIR; ETHNIC GROUP; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; POPULATION GENETICS; PRIORITY JOURNAL; RAD51L1 GENE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; TP53P1 GENE;

CASE-CONTROL STUDIES; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79954608942     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0469     Document Type: Article

References (47)

1. Jia WH, Huang QH, Liao J, Ye W, Shugart YY, Liu Q, et al. Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China. BMC Cancer 2006;6: 178.
2. Young LS, Rickinson AB. Epstein-Barr virus: 40 years on. Nat Rev Cancer 2004;4:757-68. (Pubitemid 39331148)
3. Jia WH, Feng BJ, Xu ZL, Zhang XS, Huang P, Huang LX, et al. Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China. Cancer 2004;101:363-9. (Pubitemid 38890841)
4. Yu MC, Ho JH, Lai SH, Henderson BE. Cantonese-style salted fish as a cause of nasopharyngeal carcinoma: Report of a case-control study in Hong Kong. Cancer Res 1986;46:956-61. (Pubitemid 16145462)
5. Yu MC. Nasopharyngeal carcinoma: Epidemiology and dietary factors. IARC Sci Publ 1991;105:39-47.
6. Nam JM, McLaughlin JK, Blot WJ. Cigarette smoking, alcohol, and nasopharyngeal carcinoma: A case-control study among U.S. whites. J Natl Cancer Inst 1992;84:619-22.
7. Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1999;91:1194-210. (Pubitemid 29357186)
8. Dodd LE, Sengupta S, Chen IH, den Boon JA, Cheng YJ, Westra W, et al. Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006;15:2216-25. (Pubitemid 44877048)
9. Frenkel K. Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol Ther 1992;53:127-66.
10. O'Nions J, Allday MJ. Deregulation of the cell cycle by the Epstein- Barr virus. Adv Cancer Res 2004;92:119-86. (Pubitemid 39458115)
11. Liu MT, Chen YR, Chen SC, Hu CY, Lin CS, Chang YT, et al. Epstein- Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells. Oncogene 2004;23:2531-9.
12. O'Nions J, Turner A, Craig R, Allday MJ. Epstein-Barr virus selectively deregulates DNA damage responses in normal B cells but has no detectable effect on regulation of the tumor suppressor p53. J Virol 2006;80:12408-13. (Pubitemid 44904393)
13. Gruhne B, Sompallae R, Marescotti D, Kamranvar SA, Gastaldello S, Masucci MG. The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species. Proc Natl Acad Sci USA 2009;106:2313-8.
14. Gruhne B, Sompallae R, Masucci MG. Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints. Oncogene 2009;28:3997-4008.
15. Goode EL, Ulrich CM, Potter JD. Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev 2002;11:1513-30. (Pubitemid 36020002)
16. Jiang J, Zhang X, Yang H, Wang W. Polymorphisms of DNA repair genes: ADPRT,XRCC1, and XPD and cancer risk in genetic epidemiology. Methods Mol Biol 2009;471:305-33.
17. Benhamou S, Sarasin A. ERCC2/XPD gene polymorphisms and cancer risk. Mutagenesis 2002;17:463-9. (Pubitemid 35414774)
18. Yang ZH, Dai Q, Kong XL, Yang WL, Zhang L. Association of ERCC1 polymorphisms and susceptibility to nasopharyngeal carcinoma. Mol Carcinog 2009;48:196-201.
19. Cho EY, Hildesheim A, Chen CJ, Hsu MM, Chen IH, Mittl BF, et al. Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1. Cancer Epidemiol Biomarkers Prev 2003;12:1100-4. (Pubitemid 37310270)
20. Ye YZ, Sun Y, Li LJ, Xiao XB, Zhang CQ, Feng KT. Preparation and application of a quality control sera in VCA IgA immuno-enzymatic assay (Chinese). Chin J Cancer 1997;16:79-80.
21. Wood RD, Mitchell M, Sgouros J, Lindahl T. Human DNA repair genes. Science 2001;5507:1284-9. (Pubitemid 32173086)
22. The International HapMap Consortium. The International HapMap Project. Nature 2003;426:789-96.
23. Barrett JC, Fry B, Maller J, Daly MJ. Haploview:analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5. (Pubitemid 40202029)
24. R Development Core Team. R: A language and environment for statistical computing. (V. 2.8.1). [http://www.R-project.org].
25. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: A tool set for whole-genome association and populationbased linkage analyses. Am J Hum Genet 2007;81:559-75. (Pubitemid 47330214)
26. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002;70:425-34. (Pubitemid 34112296)
27. Ge D, Zhang K, Need AC, Martin O, Fellay J, Urban TJ, et al. WGAViewer: Software for genomic annotation of whole genome association studies. Genome Res 2008;18:640-3. (Pubitemid 351482788)
28. Benjamini Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc 1995;57:289-300.
29. Therneau TM, Atkinson B, Ripley B. rpart: Recursive Partitioning. R package (V. 3.1-42). [http://cran.r-project.org/web/packages/rpart/].
30. Thacker J. The RAD51 gene family, genetic instability and cancer. Cancer Lett 2005;219:125-35. (Pubitemid 40269475)
31. Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL, et al. RAD51 135G→C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies. Am J Hum Genet 2007;81:1186-200. (Pubitemid 350211449)
32. Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, Cox DG, et al. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).Nat Genet 2009;41:579-84.
33. Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. J Biol Chem 2002;277:8406-11. (Pubitemid 34968301)
34. Takata M, Sasaki MS, Sonoda E, Fukushima T, Morrison C, Albala JS, et al. The Rad51 paralog Rad51B promotes homologous recombinational repair. Mol Cell Biol 2000;20:6476-82. (Pubitemid 30650234)
35. Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, et al. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature 2002;420:287-93. (Pubitemid 35398178)
36. Liu N, Zhou XX, Lu LX. Expression and implication of base excision repair genes in human nasopharyngeal carcinoma and non-tumor nasopharyngeal tissues. Chin J Cancer 2008;27:126-32.
37. Cho EY, Hildesheim A, Chen CJ, Hsu MM, Chen IH, Mittl BF, et al. Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1. Cancer Epidemiol Biomarkers Prev 2003;12:1100-4. (Pubitemid 37310270)
38. Yuan W, Xu L, Feng Y, Yang Y, Chen W, Wang J, et al. The hOGG1 Ser326Cys polymorphism and breast cancer risk: A meta-analysis. Breast Cancer Res Treat 2010;122:835-42.
39. Sliwinski T, Przybylowska K, Markiewicz L, Rusin P, Pietruszewska W, Zelinska-Blizniewska H, et al. MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: A case control study. Mol Biol Rep 2011;38:1251-61.
40. Simons MJ, Wee GB, Chan SH, Shanmugaratnam K. Probable identification of an HL-A second-locus antigen associated with a high risk of nasopharyngeal carcinoma. Lancet 1975;7899:142-143.
41. Hildesheim A, Apple RJ, Chen CJ, Wang SS, Cheng YJ, Klitz W, et al. Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 2002; 94:1780-9. (Pubitemid 36004354)
42. Lu SJ, Day NE, Degos L, Lepage V, Wang PC, Chan SH, et al. Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature 1990;346:470-1. (Pubitemid 120005926)
43. Feng BJ, Huang W, Shugart YY, Lee MK, Zhang F, Xia JC, et al. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet 2002;31: 395-9. (Pubitemid 35154449)
44. Xiong W, Zeng ZY, Xia JH, Xia K, Shen SR, Li XL, et al. A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res 2004;64:1972-4. (Pubitemid 38339442)
45. Bei JX, Li Y, Jia WH, Feng BJ, Zhou G, Chen LZ, et al. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet 2010;42:599-603.
46. Tse KP, Su WH, Chang KP, Tsang NM, Yu CJ, Tang P, et al. Genomewide association study reveals multiple nasopharyngeal carcinomaassociated loci within the HLA region at chromosome 6p21.3. Am J Hum Genet 2009;85:194-203.
47. Ng CC, Yew PY, Puah SM, Krishnan G, Yap LF, Teo SH, et al. A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. J Hum Genet 2009;54:392-7.