Development of a process model to describe the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase in an aqueous-organic biphasic reactor

Biotechnology and Bioengineering

Volumn 77, Issue 3, 2001, Pages 239-247

  Willeman, Wouter F ^a   Gerrits, Pieter Jan ^b   Hanefeld, Ulf ^a   Brussee, Johannes ^b   Straathof, Adrie J J ^a   Van Gen, Arne Der ^b   Heijnen, Joseph J ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Biphasic; Cyanohydrins; Hydroxynitriles; Oxynitrilase; Process model; Prunus amygdalus hydroxynitrile lyase; Stirred tank reactor

Indexed keywords

ETHERS; MASS TRANSFER; PH EFFECTS; REACTION KINETICS; SUBSTRATES;

AQUEOUS-ORGANIC BIPHASIC REACTORS;

ENZYME KINETICS;

CYANOHYDRIN; HYDROXYNITRILE LYASE; MANDELONITRILE; NITRILE; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ALMOND; AQUEOUS SOLUTION; ARTICLE; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; ENANTIOMER; ENZYME KINETICS; PHYTOCHEMISTRY; PROCESS MODEL; REACTOR; SYNTHESIS; VALIDATION PROCESS;

ACETONITRILES; ALDEHYDE-LYASES; BIOREACTORS; BIOTECHNOLOGY; KINETICS; MODELS, BIOLOGICAL; PRUNUS; REPRODUCIBILITY OF RESULTS; SOLVENTS;

PRUNUS; PRUNUS DULCIS;

EID: 0035809226     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10002     Document Type: Article

References (27)

1. D-hydroxynitrile lyase: Involvement of the prosthetic flavin adenine dinucleotide in enzyme activity
2. Biocatalysis in the enantioselective formation of chiral cyanohydrins, valuable building blocks in organic synthesis
3. Biocatalysis in water-organic solvent two-phase systems
4. Enzymes, for flavor production
5. Chirality in industry - An overview
6. L-phenylalanine production process utilizing enzymatic resolution in the presence of an organic solvent
7. Synthese und reaktionen optisch aktiver cyan-hydrine
8. Mass transport limitation as a tool to enhance the enantiomeric excess in the enzymatic synthesis of chiral cyanohydrins
9. Cyanohydrins in nature and the laboratory: Biology, preparations and synthetic applications
10. Enzyme catalysed formation of (S)cyanohydrins derived from aldehydes and ketones in a biphasic solvent system
11. The synthesis of chiral cyanohydrins by oxynitrilases
12. Hydroxynitrile lyases: Functions and properties
13. Hydroxynitrile lyase at the diisopropyl ether/water interface: Evidence for interfacial enzyme activity
14. Biocatalytic applications of hydroxynitrile lyases
15. Continuous hydrolysis of oil by immobilized lipase in a countercurrent reactor
16. Enzymatic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous medium
17. Synthesis of optically active cyanohydrins using R-oxynitrilase in a liquid-liquid biphasic system
18. Diltiazem synthesis
19. Syntheses of homochiral cyanohydrins in an industrial environment: Hydroxynitrile lyases offer new options
20. Development of a computer program for analysis of enzyme kinetics by process curve fitting
21. The application of organic solvents for the bioconversion of benzene to cis-benzeneglycol
22. The potential of (R)- and (S)-oxynitrilases for the enzymatic synthesis of optically active cyanohydrins
23. Continuous control of water activity during biocatalysis in organic media
24. Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase
25. Cyanohydrin formation, preparation of optically active cyanohydrins using oxynitrilase from almond meal