Cardiotoxicity with modern local anaesthetics: Is there a safer choice?

Drugs

Volumn 61, Issue 3, 2001, Pages 333-342

  Mather, L E ^a   Chang, D H T ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CINCHOCAINE; COCAINE; ETIDOCAINE; LEVOBUPIVACAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; PROCAINE; ROPIVACAINE; SODIUM CHANNEL; TETRACAINE;

ARRHYTHMOGENESIS; CARDIOTOXICITY; CHRONOTROPISM; CLINICAL TRIAL; DRUG INDUCED DISEASE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; INOTROPISM; LETHAL DOSE; LOCAL ANESTHESIA; NERVE BLOCK; NEUROTOXICITY; NONHUMAN; REVIEW;

ANIMALIA;

EID: 0035064687     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200161030-00002     Document Type: Review

References (62)

1. Studies on the duration of local anaesthesia: Structure/activity relationships in a series of homologous local anaesthetics
2. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine
3. Cardiac arrest following caudal anesthesia
4. Toxicological and local anesthetic effects of optically active isomers of two local anesthetic compounds
5. Primary evaluation of the local anesthetic properties of the amino amide agent ropivacaine (LEA 103)
6. Cardiotoxicity of local anaesthetic agents
7. Local anesthetic toxicity: An update
8. Stereoselective inhibition of neuronal sodium channels by local anesthetics: Evidence for two sites of action?
9. Stereoselectivity of bupivacaine in local anesthetic-sensitive ion channels of peripheral nerve
10. Ropivacaine and the cardiac sodium current
11. Stereoselective block of cardiac sodium channels by bupivacaine in guineapig ventricular myocytes
12. max)
13. Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle
14. Cardiotoxic effects of levobupivacaine, bupivacaine and ropivacaine: An in vitro study in guinea-pig and human cardiac muscle
15. Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic
16. Differential effects of bupivacaine on cardiac K channels: Role of channel inactivation and subunit composition in drug-channel interaction
17. The cardiac effects of bupivacaine and ropivacaine on contractility and action potentials of isolated guinea-pig atria: Influence of different extracellular potassium concentrations
18. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers
19. Effects of ropivacaine on a potassium channel (hKv 1.5) cloned from human ventricle
20. Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine and ropivacaine in the sheep
21. Direct chronotropic and inotropic effects of local anesthetic agents in isolated guineapig atria
22. Depression of myocardial contractility in vitro by bupivacaine, etidocaine, and lidocaine
23. Effects of bupivacaine on membrane currents of guinea-pig ventricular myocytes
24. The contribution of Na channel block to the negative inotropic effect of antiarrhythmic drugs
25. Contractility effects of local anesthetics in the presence of sodium channel blockade
26. In vitro study on mechanisms of bupivacaine-induced depression of myocardial contractility
27. Experimental evidence in favor of role of intracellular actions of bupivacaine in myocardial depression
28. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics
29. Mitochondrial effects of L-ropivacaine, a new local anesthetic
30. Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria
31. Bupivacaine inhibits cyclic-3',5'-adenosine monophosphate production: A possible contributing factor to cardiovascular toxicity
32. S(-) bupivacaine and RS(±) bupivacaine: A comparison of effects on the right and left atria of the rat
33. Chronotropic and inotropic effects of ropivacaine, bupivacaine, and lidocaine in the spontaneously beating and electrically paced isolated, perfused rabbit heart
34. Myocardial uptake of bupivacaine: II. Pharmacokinetics and pharmacodynamics of bupivacaine enantiomers in the isolated perfused rabbit heart
35. Comparative effect of racemic bupivacaine, levobupivacaine and ropivacaine on isolated rabbit heart
36. Stereospecific effect of bupivacaine isomers on atrioventricular conduction in the isolated perfused guinea-pig heart
37. Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse
38. Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine, and ropivacaine in sheep
39. Disposition of mepivacaine and bupivacaine enantiomers in sheep
40. Cardiovascular and central nervous system effects of bupivacaine and levobupivacaine in sheep
41. Tolerability of large dose intravenous levobupivacaine in sheep
42. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep
43. Effect of local anesthetic agents on cardiac conduction and contractility
44. A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine, and ropivacaine in anesthetized swine
45. Enantiomer-specific effects of an intravenously administered arrhythmogenic dose of bupivacaine on neurons of the nucleus tractus solitarius and the cardiovascular system in the anesthetized rat
46. Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog
47. Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog
48. The effect of local anaesthetics on the central circulation and respiration in man and dog
49. The intravenous toxicity and clearance of bupivacaine in man
50. Cardiovascular and subjective central nervous system effects of long-acting local anaesthetics in man
51. Bupivacaine (Marcaine): An evaluation of its tissue and systemic toxicity in humans
52. Acute toxicity of ropivacaine compared with that of bupivacaine
53. Central nervous and cardiovascular effects of i.v. Infusions of ropivacaine, bupivacaine and placebo in volunteers
54. A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers
55. Central nervous system toxicity attributable to epidural ropivacaine hydrochloride
56. Accidental intravenous levobupivacaine
57. Two instances of central nervous system toxicity in the same patient following repeated ropivacaine-induced brachial plexus block
58. Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: Implications for therapeutic indexes
59. Relative potencies of bupivacaine and ropivacaine for analgesia in labour
60. Epidural pain relief in labour: Potencies of levobupivacaine and racemic bupivacaine