The endoproteolytic maturation of progastrin and procholecystokinin

Journal of Molecular Medicine

Volumn 84, Issue 7, 2006, Pages 544-550

  Rehfeld, Jens F ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

Biosynthesis; Cholecystokinin; Gastrin; Hormones; Neuropeptides; Prohormone Convertases

Indexed keywords

ARGININE; BRAIN PEPTIDE; CHOLECYSTOKININ; CORTICOTROPIN; FURIN; PROCHOLECYSTOKININ; PROGASTRIN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

BINDING SITE; CCK GENE; CELL SPECIFICITY; ENDOCRINE CELL; GENE; GENE EXPRESSION REGULATION; INTESTINE CELL; NERVE CELL; NEUROSECRETORY CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PROCESSING; REVIEW;

ANIMALS; CHOLECYSTOKININ; GASTRINS; HUMANS; PEPTIDE HYDROLASES; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 33745605514     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-006-0055-3     Document Type: Review

References (86)

1. Edkins JS (1905) On the chemical mechanism of gastric secretion. Proc Roy Soc Ser B 76:376
2. Ivy AC, Oldberg E (1928) A hormone mechanism for gallbladder contraction and evacuation. Am J Physiol 86:599-613
3. Harper AA, Raper HS (1943) Pancreozymin, a stimulant of the secretion of pancreatic enzymes in extracts of the small intestine. J Physiol 102:115-125
4. Jorpes E, Mutt V (1966) Cholecystokinin and pancreozymin, one single hormone? Acta Physiol Scand 66:196-202
5. Gregory H, Hardy PM, Jones DS, Kenner GW, Sheppard RC (1964) The antral hormone gastrin. Structure of gastrin. Nature 204:931-933
6. Mutt V, Jorpes JE (1968) Structure of porcine cholecystokinin- pancreozymin. 1. Cleavage with thrombin and with trypsin. Eur J Biochem 6:156-162
7. Anastasi A, Erspamer W, Endean R (1967) Isolation and structure of caerulein, an active decapeptide from the skin of Hylacaerulea. Experientia 23:699-700
8. Larsson L-I, Rehfeld JF (1977) Evidence for a common evolutionary origin of gastrin and cholecystokinin. Nature 269:335-338
9. Johnsen AH, Rehfeld JF (1990) Cionin: A disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis. J Biol Chem 265:3054-3058
10. Rehfeld JF (1998) The new biology of gastrointestinal hormones. Physiol Rev 78:1087-1108
11. Rehfeld JF (1978) Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog. J Biol Chem 253:4022-4030
12. Crawley JE (1985) Distribution of cholecystokinin and other neuropeptides: why is this peptide different from all other peptides? Ann N Y Acad Sci 448:1-8
13. Johnson LR (1989) In: Makhlouf GM (ed) Handbook of physiology. The gastrointestinal system: neural and endocrine biology (Section 6, vol. 2). American Physiological Society, Bethesda, Maryland, pp 291310
14. Johnson LR (1976) The trophic action of gastrointestinal hormones. Gastroenterology 70:278-288
15. Anastasi A, Bertaccini G, Cei JM, de Caro G, Erspamer V, Impicciatore M (1969) Structure and pharmacological actions of phyllocaerulein, a caerulein-like nonapeptide: its occurrence in extracts of the skin of Phyllomedusa sauvagei and related Phyllomedusa species. Br J Pharmacol 37:198-206
16. Morley JS, Tracy HJ, Gregory RA (1965) Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin. Nature 207:1356-1359
17. Andersen BN (1985) Species variation in the tyrosine sulfation of mammalian gastrins. Gen Comp Endocrinol 58:44-50
18. Seva C, Dickinson CJ, Yamada T (1994) Growth promoting effects of glycine-extended progastrin. Science 265:410-412
19. Dockray GJ, Varro A, Dimaline R, Wang T (2001) The gastrins: their production and biological activities. Annu Rev Physiol 63:119-139
20. Rehfeld JF (1998) Accurate measurement of cholecystokinin in plasma. Clin Chem 44:991-1001
21. Rehfeld JF (1978) Localisation of gastrins to neuro- and adenohypophysis. Nature 271:771-773
22. Walsh JH, Isenberg JI, Ansfield J, Maxwell V (1976) Clearance and acid-stimulating action of human big and little gastrins in duodenal ulcer subjects. J Clin Invest 57:1125-1131
23. Kopin AS, Lee Y-M, McBride EW, Miller LJ, Lu M, Lin HY, Kolakowski LF, Beinbom M (1992) Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci USA 89:3605-3609
24. Wank SA, Harkins R, Jensen RT, Shapira H, de Weerth A, Slattery T (1992) Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas. Proc Natl Acad Sci USA 89:3125
25. Brodin K, Nilsson G, Håkanson R, Sundler F (1979) Time dependent increase in duodenal gastrin concentration in dogs following antrectomy. Acta Physiol Scand 47:112-116
26. Brand SJ, Klarlund J, Schwartz TW, Rehfeld JF (1984) Biosynthesis of tyrosine-0-sulfated gastrins in rat antral mucosa. J Biol Chem 259:13246-13252
27. Hilsted L, Rehfeld JF (1987) α-carboxyamidation of antral progastrin: relation to other post-translational modifications. J Biol Chem 262:16953-16957
28. Jensen S, Borch K, Hilsted L, Rehfeld JF (1989) Progastrin processing during antral G-cell hypersecretion in humans. Gastroenterology 96:1063-1070
29. Sugano K, Aponte GW, Yamada T (1985) Identification and characterization of glycine-extended post-translational processing intermediates of progastrin in porcine stomach. J Biol Chem 260:11724-11729
30. Rehfeld JF, Lindberg I, Friis-Hansen L (2002) Progastrin processing differs in 7B2 and PC2 knockout animals: a role for 7B2 independent of action on PC2. FEBS Lett 510:89-93
31. Eipper BA, Stoffers DA, Mains RE (1992) The biosynthesis of neuropeptides: peptide alpha-amidation. Annu Rev Neurosci 15:57-85
32. Dockray GJ, Varro A, Desmond H, Young J, Gregory H, Gregory RA (1987) Posttranslational processing of the porcine gastrin precursor by phosphorylation of the COOH-terminal fragment. J Biol Chem 262:8643-8647
33. Rehfeld JF, Johnsen AH (1994) Identification of gastrin component I as gastrin71, the largest possible bioactive progastrin product. Eur J Biochem 223:765-773
34. Rehfeld JF, Hansen CP, Johnsen AH (1995) Post-poly (Glu) cleavage and degradation modified by O-sulfated tyrosine: a novel posttranslational processing mechanism. EMBO J 12:389-396
35. Borch K, Renvall H, Liedberg G, Andersen BN (1986) Relations between circulating gastrin and endocrine cell proliferation in the atrophic gastric fundic mucosa. Scand J Gastroenterol 21:357-363
36. Larsson L-I, Rehfeld JF (1979) A peptide resembling the COOH-terminal tetrapeptide amide of gastrin from a new gastrointestinal endocrine cell type. Nature 277:575-578
37. Lüttichau HR, van Solinge WW, Nielsen FC, Rehfeld JF (1993) Developmental expression of the gastrin and cholecystokinin genes in rat colon. Gastroenterology 104:1092-1098
38. van Solinge WW, Nielsen FC, Friis-Hansen L, Falkmer UG, Rehfeld JF (1993) Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology 104:1099-1107
39. Larsson L-I, Rehfeld JF, Håkanson R, Sundler F (1976) Pancreatic gastrin in foetal and neonatal rats. Nature 262:607-611
40. Brand SJ, Andersen BN, Rehfeld JF (1984) Complete tyrosyl-0-sulfation of gastrin in neonatal rat pancreas. Nature 309:456-458
41. Bardram L, Hilsted L, Rehfeld JF (1990) Progastrin expression in mammalian pancreas. Proc Natl Acad Sci USA 87:298-302
42. Larsson L-I, Rehfeld JF (1981) Pituitary gastrins occur in corticotrophs and melanotrophs. Science 213:768-770
43. Rehfeld JF, Hansen HF, Larsson L-I, Stengaard-Pedersen K, Thorn NA (1984) Gastrin and cholecystokinin in pituitary neurons. Proc Natl Acad Sci USA 81:1902-1905
44. Rehfeld JF (1986) Accumulation of non-amidated preprogastrin and preprocholecystokinin products in the porcine pituitary corticotrophs: evidence of post-translational control of cell differentiation. J Biol Chem 261:5841-5847
45. Rehfeld JF (1991) Progastrin and its products in the cerebellum. Neuropeptides 20:239-245
46. Uvnäs-Wallensten K, Rehfeld JF, Larsson L-I, Uvnäs B (1977) Heptadecapeptide gastrin in the vagal nerve. Proc Natl Acad Sci USA 74:5707-5710
47. Bardram L, Hilsted L, Rehfeld JF (1989) Cholecystokinin, gastrin and their precursors in pheochromocytomas. Acta Endocrinol 120:479-484
48. Rehfeld JF, Bardram L, Hilsted L (1989) Gastrin in bronchogenic carcinomas: constant expression but variable processing of progastrin. Cancer Res 49:2840-2843
49. van Solinge WW, Ødum L, Rehfeld JF (1993) Ovarian cancer express and process progastrin. Cancer Res 53:1823-1830
50. Schalling M, Persson H, Pelto-Huikko M, Ødum L, Ekman P, Gottlieb C, Hökfelt T, Rehfeld JF (1990) Expression and localization of gastrin mRNA and peptide in human spermatogenic cells. J Clin Invest 86:660-669
51. Rehfeld JF, van Solinge WW (1994) The tumor biology of gastrin and cholecystokinin. Adv Cancer Res 63:295-346
52. Rehfeld JF, Larsson LI (1981) Pituitary gastrin: different processing in corticotrophs and melanotrophs. J Biol Chem 256:10426-10429
53. Zhou A, Bloomquist BT, Mains RE (1993) The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing. J Biol Chem 268:1763-1769
54. Furuta M, Yano H, Zhou A, Rouillé Y, Holst JJ, Carroll R, Ravazzola M, Orci L, Furuta H, Steiner DF (1997) Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci USA 94:6646-6651
55. Larsson L-I (1980) Gastrointestinal cells producing endocrine, neurocrine and paracrine messengers. Clin Gastroenterol 9:485-516
56. Golterman NR, Rehfeld JF, Petersen HR (1980) In vivo biosynthesis of cholecystokinin in rat cerebral cortex. J Biol Chem 255:6181-6185
57. Stengaard-Pedersen K, Larsson L-I, Fredens K, Rehfeld JF (1984) Modulation of cholecystokinin concentration in the rat hippocampus by chelation of heavy metals. Proc Natl Acad Sci USA 81:5867-5870
58. Blanke SE, Johnsen AH, Rehfeld JF (1993) N-terminal fragments of intestinal cholecystokinin. Regul Pept 46:575-582
59. Dockray GJ, Gregory RA, Hutchison JB, Harris JI, Runswick MJ (1978) Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain. Nature 274:711-713
60. Eberlein GA, Eysselein VE, Davis MT, Lee TD, Shively JE, Grandt D, Niebel N, Williams R, Moessner J, Zeeh J, Meyer HE, Goebell H, Reeve JR (1992) Patterns of prohormone processing. Order revealed by a new procholecystokinin- derived peptide. J Biol Chem 267:1517-1521
61. Eng J, Shiina Y, Pan YC, Blacher R, Chang M, Stein S, Yalow RS (1983) Pig brain contains cholecystokinin octapeptide and several cholecystokinin desoctapeptides. Proc Natl Acad Sci USA 80:6381-6385
62. Mutt V, Jorpes JE (1971) Hormonal polypeptides of the upper intestine. Biochem J 125:57P-58P
63. Mutt V (1976) Further investigations of intestinal hormonal polypeptides. Clin Endocrinol 5:175S-183S
64. Reeve JR, Eysselein VE, Eberlein GA, Chew P, Ho F-J, Huebner VD, Shively JE, Lee TD, Liddle RA (1991) Characterization of canine intestinal cholecystokinin58 lacking its carboxyl-terminal nonapeptide. Evidence for similar post-translational processing in brain and gut. J Biol Chem 266:13770-13776
65. Rehfeld JF, Hansen HF (1986) Characterization of preprocholecystokinin products in the porcine cerebral cortex: evidence of different processing pathways. J Biol Chem 261:5832-5840
66. Eng J, Du BH, Pan YE, Chang M, Hulmes JD, Yalow RS (1984) Purification and sequencing of a rat intestinal 22 amino acid C-terminal CCK fragment. Peptides 5:1203-1206
67. Rehfeld JF, Lindberg I, Friis-Hansen L (2002) Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals. J Neurochem 83:1329-1337
68. Reeve JR, Eysselein V, Walsh JH, Ben-Avram CH, Shively JE (1986) New molecular forms of cholecystokinin. Microsequence analysis of forms previously characterized by chromatographic methods. J Biol Chem 261:16392-16397
69. Rehfeld JF, Sun G, Christensen T, Hillingsø JG (2001) The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33. J Clin Endocrinol Metab 86:251-258
70. Shively J, Reeve JR, Eysselein VE, Ben-Avram C, Vigna SR, Walsh JH (1987) CCK-5: sequence analysis of a small cholecystokinin from canine brain and intestine. Am J Physiol 252:G272-G275
71. Cantor P, Rehfeld JF (1989) Cholecystokinin in pig plasma: release of components devoid of a bioactive C terminus. Am J Physiol 256:G53-G61
72. Eberlein GA, Eysselein VE, Goebell H (1988) Cholecystokinin-58 is the major molecular form in man, dog and cat but not in pig, beef and rat intestine. Peptides 9:993-998
73. Rehfeld JF (1994) The molecular nature of cholecystokinin in plasma. An in vivo study in rabbits. Scand J Gastroenterol 29:110-121
74. Larsson L-I, Rehfeld JF (1979) Localization and molecular heterogeneity of cholecystokinin in the central and peripheral nervous system. Brain Res 165:201-218
75. Mogensen NW, Hilsted L, Bardram L, Rehfeld JF (1990) Procholecystokinin processing in the rat cerebral cortex during development. Dev Brain Res 54:81-86
76. Rehfeld JF, Mogensen NW, Bardram L, Hilsted L, Monstein HJ (1992) Expression, but failing maturation of procholecystokinin in cerebellum. Brain Res 576:111-119
77. Rehfeld JF (1987) Preprocholecystokinin processing in the normal human anterior pituitary. Proc Natl Acad Sci USA 84:3019-3024
78. Rehfeld JF, Johnsen AH, Ødum L, Bardram L, Schifter S, Scopsi L (1990) Nonsulfated cholecystokinin in human medullary thyroid carcinomas. J Endocrinol 124:501-506
79. Ghatei MA, Sheppard MN, O'Shaughnessy DJ, Adrian TE, Gregor GM, Polak JM, Bloom SR (1982) Regulatory peptides in the mammalian respiratory tract. Endocrinology III:1248-1254
80. Persson H, Rehfeld JF, Ericsson A, Schalling M, Pelto-Huikko M, Hökfelt T (1989) Transient expression of the cholecystokinin gene in male germ cells and accumulation of the peptide in the acrosomal granule: possible role of cholecystokinin in fertilization. Proc Natl Acad Sci USA 86:6166-6170
81. Zhu X, Zhou A, Dey A, Norrbom C, Caroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, Steiner DF (2002) Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci USA 99:10293-10298
82. Vishnuvardhan D, Conolly K, Cain B, Beinfeld MC (2000) PC2 and 7B2 null mice demonstrate that PC2 is essential for normal proCCK processing. Biochem Biophys Res Commun 273:188-191
83. Cain BM, Conolly K, Blum A, Vishnuvardhan D, Marchand JE, Beinfeld M (2003) Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2 and PC5 in rat brain. J Comp Neurol 467:307-325
84. Beinfeld MC, Blum A, Vishnuvardhan D, Fanous S, Marchand JE (2005) Cholecystokinin levels in prohormone convertase 2 knock-out mouse brain regions reveal a complex phenotype of region-specific alterations. J Biol Chem 280:38410-38415
85. Cain BM, Vishnuvardhan D, Beinfeld M (2001) Neuronal cell lines expressing PC5, but not PC1 and PC2, process proCCK into glycine-extended CCK 12 and 22. Peptides 22:1271-1277
86. Reynolds NA, Blum A, Kitagawa K, Beinfeld M (2006) Inhibition of PC5 expression decreases CCK secretion and increases PC2 expression. Peptides 27(4):901-904