Drug metabolism in hemorrhagic shock: Pharmacokinetics of selective markers of cytochrome-P450 2C9, 2D6, and 3A4 enzyme activities in a porcine model

Journal of Surgical Research

Volumn 167, Issue 2, 2011, Pages

  Kumar, Atul ^a   Remmel, Rory P ^a   Mann, Henry J ^c   Beilman, Greg J ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

cytochrome P450; dextromethorphan; flurbiprofen; glucuronide; midazolam; pharmacokinetics; physiology; pig; resuscitation; shock

Indexed keywords

4' HYDROXYFLURBIPROFEN; ALPHA HYDROXYMIDAZOLAM; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; FLURBIPROFEN; MIDAZOLAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; ENZYME ACTIVITY; HEMORRHAGIC SHOCK; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; BIOLOGICAL MARKERS; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; DOSE-RESPONSE RELATIONSHIP, DRUG; FLURBIPROFEN; INJECTIONS, INTRAVENOUS; MIDAZOLAM; MODELS, ANIMAL; RESUSCITATION; SHOCK, HEMORRHAGIC; SWINE;

EID: 79954570089     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.06.040     Document Type: Article

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