Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 853, Issue 1-2, 2007, Pages 287-293

  Kumar, Atul ^a   Mann, Henry J ^a   Remmel, Rory P ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cytochrome P450; Dextromethorphan; Flurbiprofen; LC MS; Midazolam; Pharmacokinetics; Phenotyping; Pig

Indexed keywords

CYTOCHROME P450; DEXTROMETHORPHAN; FLURBIPROFEN; PHENOTYPING;

DRUG PRODUCTS; EXTRACTION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN);

ENZYMES;

4' HYDROXYFLURBIPROFEN; ALPHA HYDROXYMIDAZOLAM; CYTOCHROME P450; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; FLURBIPROFEN; MIDAZOLAM; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; ELECTROSPRAY; ENZYME ACTIVITY; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION MONITORING; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; SPECTROFLUOROMETRY; SWINE;

ANALGESICS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; FLURBIPROFEN; MASS SPECTROMETRY; MIDAZOLAM; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, FLUORESCENCE; SWINE;

SUIDAE;

EID: 34250023220     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.03.032     Document Type: Article

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