The suppressive effects of lipopolysaccharide-induced acute phase response on hepatic cytochrome P450-dependent drug metabolism in rabbits

Journal of Veterinary Pharmacology and Therapeutics

Volumn 22, Issue 2, 1999, Pages 87-95

  Saitoh, T ^a,b   Kokue, E ^a   Shimoda, M ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b NIPPON INSTITUTE FOR BIOLOGICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CYTOCHROME P450; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PHENAZONE;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; MICHAELIS CONSTANT; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RABBIT; RECTUM TEMPERATURE;

ACUTE-PHASE REACTION; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; BLOTTING, WESTERN; BODY TEMPERATURE; CYTOCHROME P-450 ENZYME SYSTEM; DEPRESSION, CHEMICAL; ENDOTOXINS; ESCHERICHIA COLI; FEMALE; GLUCURONOSYLTRANSFERASE; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; RABBITS; SERUM ALBUMIN;

ANIMALIA; ESCHERICHIA COLI; ORYCTOLAGUS CUNICULUS;

EID: 0032990513     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1999.00195.x     Document Type: Article

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