Solvent-free Biginelli reaction: A green method for the synthesis of 3,4-dihydropyrimidin-2-ones catalyzed by protic acids in large-scale

Letters in Organic Chemistry

Volumn 8, Issue 4, 2011, Pages 264-267

  Wang, Yangyun ^a   Yu, Jipan ^a   Yang, Haohao ^a   Miao, Zhiwei ^a   Chen, Ruyu ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

3,4 dihydropyrimidin 2 ones; Biginelli reaction; Large scale; Mechanochemical reaction; Solvent free reaction

Indexed keywords

EID: 79954526497     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017811795371386     Document Type: Article

References (47)

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43. General Procedure for the efficient Biginelli reaction: A mixture of aldehydes (0.1 mol), urea or thiourea (0.1 mol), p-ketoester (0.1 mol) and 20 mol% amounts of conc. hydrochloric acid (20 mmol) was contained in a mortar, then mixed and grinded for one minute. The mixture was irradiated under the infrared light for indicated time in Table 2. The residue was poured into crushed ice, and the solid product was separated, filtered, recrystallized from hot ethanol to afford pure product.
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