Species difference between cynomolgus monkeys and humans on cytochromes P450 2D and 3A-dependent drug oxidation activities in liver microsomes

Journal of Health Science

Volumn 57, Issue 2, 2011, Pages 164-170

  Emoto, Chie ^a   Iwasaki, Kazuhide ^b   Koizumi, Ryo ^a   Utoh, Masahiro ^b   Murayama, Norie ^a   Uno, Yasuhiro ^b   Yamazaki, Hiroshi ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

Cynomolgus monkey; Cytochrome P450; Cytochrome P450 2D; Cytochrome P450 3A; Human

Indexed keywords

BUFURALOL; CYTOCHROME P450; CYTOCHROME P450 2D; CYTOCHROME P450 2D17; CYTOCHROME P450 2D44; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; DEXTROMETHORPHAN; MIDAZOLAM; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG DETERMINATION; DRUG HYDROXYLATION; DRUG OXIDATION; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; FEMALE; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; LIVER MICROSOME METABOLISM; MACACA FASCICULARIS; MALE; NONHUMAN; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

MACACA FASCICULARIS;

EID: 79954522718     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.57.164     Document Type: Article

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