A novel monoclonal antibody against FbaA can inhibit the binding of the complement regulatory protein factor H to group A streptococcus∇

Clinical and Vaccine Immunology

Volumn 18, Issue 4, 2011, Pages 552-558

  Ma, Cuiqing ^a   Guo, Yiyang ^a   Gu, Haiyan ^a   Zhang, Ling ^a   Liu, Hainan ^a   Feng, Huidong ^a   Wei, Lin ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; COMPLEMENT FACTOR H; EPITOPE; FBAA PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY FBAA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY COMBINING SITE; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; STREPTOCOCCUS GROUP A; STREPTOCOCCUS PYOGENES;

ADHESINS, BACTERIAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; BINDING SITES; CARRIER PROTEINS; COMPLEMENT FACTOR H; EPITOPE MAPPING; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; STREPTOCOCCUS PYOGENES;

EID: 79954499612     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00438-10     Document Type: Article

References (33)

1. Areschoug, T., M. Stalhammar-Carlemalm, I. Karlsson, and G. Lindahl. 2002. Streptococcal beta protein has separate binding sites for human factor H and IgA-Fc. J. Biol. Chem. 277:12642-12648.
2. Cleary, P. P., D. LaPenta, R. Vessela, H. Lam, and D. Cue. 1998. A globally disseminated M1 subclone of group A streptococci differs from other subclones by 70 kilobases of prophage DNA and capacity for high-frequency intracellular invasion. Infect. Immun. 66:5592-5597.
3. Cue, D., P. E. Dombek, and P. P. Cleary. 2000. Intracellular invasion by Streptococcus pyogenes: invasins, host receptors, and relevance to human disease, p. 27-33. In V. A. Fischetti et al. (ed.), Gram-positive pathogens. American Society for Microbiology, Washington, DC.
4. Cue, D., P. E. Dombek, H. Lam, and P. P. Cleary. 1998. Streptococcus pyogenes serotype M1 encodes multiple pathways for entry into human epithelial cells. Infect. Immun. 66:4593-4601.
5. Cuiqing, M., et al. 2009. Similar ability of FbaA with M protein to elicit protective immunity against group A streptococcus challenge in mice. Cell Mol. Immunol. 6:73-77.
6. Cunningham, M. W. 2000. Pathogenesis of group A streptococcal infections. Clin. Microbiol. Rev. 13:470-511.
7. Dave, S., A. Brooks-Walter, M. K. Pangburn, and L. S. McDaniel. 2001. PspC, a pneumococcal surface protein, binds human factor H. Infect. Immun. 69:3435-3437.
8. Duthy, T. G., et al. 2002. The human complement regulator factor H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15. Infect. Immun. 70:5604-5611.
9. Ezzat, M.-K., et al. 2008. Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin. Exp. Eye Res. 87:376-384.
10. Hong, S. S., and P. Boulanger. 1995. Protein ligands of the human adenovirus type 2 outer capsid identified by biopanning of a phage-displayed peptide library on separate domains of wild-type and mutant penton capsomers. EMBO J. 14:4714-4727.
11. Horstmann, R. D., H. J. Sievertsen, J. Knobloch, and V. A. Fischetti. 1988. Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H. Proc. Natl. Acad. Sci. U. S. A. 85:1657-1661.
12. Janulczyk, R., F. Iannelli, A. G. Sjoholm, G. Pozzi, and L. Bjorck. 2000. Hic, a novel surface protein of Streptococcus pneumoniae that interferes with complement function. J. Biol. Chem. 275:37257-37263.
13. Jarva, H., et al. 2002. Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H. J. Immunol. 168:1886-1894. (Pubitemid 34135790)
14. Johnsson, E., et al. 1996. A highly variable region in members of the streptococcal M protein family binds the human complement regulator C4BP. J. Immunol. 157:3021-3029. (Pubitemid 126450061)
15. Johnsson, E., et al. 1998. Role of the hypervariable region in streptococcalM proteins: binding of a human complement inhibitor. J. Immunol. 161:4894-4901. (Pubitemid 28492068)
16. Kotarsky, H., et al. 1998. Identification of a domain in human factor H and factor H-like protein-1 required for the interaction with streptococcal M proteins. J. Immunol. 160:3349-3354. (Pubitemid 28164727)
17. Kraiczy, P., et al. 2003. Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family. Eur. J. Immunol. 33:697-707.
18. LaPenta, D., C. Rubens, E. Chi, and P. P. Cleary. 1994. Group A streptococci efficiently invade human respiratory epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 91:12115-12119.
19. Lin, W., V. Pandiripally, E. Gregory, M. Clymer, and D. Cue. 2005. Impact of the SpeB protease on binding of the complement regulatory proteins factor H and Factor H-Like protein 1 by Streptococcus pyogenes Infect. Immun. 73:2040-2050. (Pubitemid 40470802)
20. Medina, E., O. Goldmann, A. W. Toppel, and G. S. Chhatwal. 2003. Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion. J. Infect. Dis. 187:597-603.
21. Molinari, G., and G. S. Chhatwal. 1999. Role played by the fibronectin-binding protein SfbI (protein F1) of Streptococcus pyogenes in bacterial internalization by epithelial cells. J. Infect. Dis. 179:1049-1050.
22. Neeman, R., N. Keller, A. Barzilai, Z. Korenman, and S. Sela. 1998. Prevalence of internalisation-associated gene, prtF1, among persisting group A streptococcus strains isolated from asymptomatic carriers. Lancet 352:1974-1977. (Pubitemid 29000864)
23. Olive, C. 2007. Progress in M-protein-based subunit vaccines to prevent rheumatic fever and rheumatic heart disease. Curr. Opin. Mol. Ther. 9:25-34.
24. Ozeri, V., et al. 2001. De novo formation of focal complex-like structures in host cells by invading streptococci. Mol. Microbiol. 41:561-573.
25. Pandiripally, V., E. Gregory, and D. Cue. 2002. Acquisition of regulators of complement activation by Streptococcus pyogenes serotype M1. Infect. Immun. 70:6206-6214.
26. Pandiripally, V., L. Wei, C. Skerka, P. F. Zipfel, and D. Cue. 2003. Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group a streptococci. Infect. Immun. 71:7119-7128.
27. Podbielski, A., M. Woischnik, B. Pohl, and K. H. Schmidt. 1996. What is the size of the group A streptococcal vir regulon? The Mga regulator affects expression of secreted and surface virulence factors. Med. Microbiol. Immunol. 185:171-181.
28. Ram, S., et al. 1998. Binding of complement factor H to loop 5 of porin protein 1A: a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae. J. Exp. Med. 188:671-680.
29. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
30. Scott, J. K., D. Loganathan, R. B. Easley, X. Gong, and I. J. Goldstein. 1992. A family of concanavalin A-binding peptides from a hexapeptide epitope library. Proc. Natl. Acad. Sci. U. S. A. 89:5398-5402.
31. Sela, S., R. Neeman, N. Keller, and A. Barzilai. 2000. Relationship between asymptomatic carriage of Streptococcus pyogenes and the ability of the strains to adhere to and be internalized by cultured epithelial cells. J. Med. Microbiol. 49:499-502.
32. Terao, Y., et al. 2001. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Mol. Microbiol. 42:75-86.
33. Zipfel, P. F., and C. Skerka. 1999. FHL-1/reconectin: a human complement and immune regulator with cell-adhesive activity. Immunol. Today 20:135-140. (Pubitemid 29130343)